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DNA Cassettes Enable Long-Lasting Antibody Production Directly Inside Patients

A multidisciplinary team of scientists led by The Wistar Institute, including Perelman School of Medicine at the University of Pennsylvania, AstraZeneca and Inovio Pharmaceuticals, published today in Nature Medicine a breakthrough in biologic antibody production that happens directly in human subjects in this encouraging first clinical trial of its kind.

23 Oct 2025

Research Pinpoints HMGN1 as Cause of Trisomy 21-Related Heart Abnormalities

Three copies of chromosome 21 causes Down syndrome (DS), and roughly half of children born each year in the United States with DS-approximately 2,600-also have congenital heart defects (CHDs).

23 Oct 2025

Fully Automated 3D Framework Accurately Maps Fruit Microstructure

Applied to apple and pear fruit, the model achieved very high accuracy, outperforming previous 2D approaches and traditional algorithms.

23 Oct 2025

Ingestible Bioprinter Revolutionizes Possibilities for Non-Invasive Tissue Repair

The MEDS device enables non-invasive tissue repair in the GI tract, utilizing innovative bioprinting techniques for effective treatment of internal lesions.

23 Oct 2025

Mapping the Molecular Choreography of Nuclear Pore Transport

Nuclear pore complexes (NPCs) are tiny but sophisticated gatekeepers that control the flow of materials between a cell's nucleus and its cytoplasm by quickly selecting which molecules to transport across the nuclear membrane.

22 Oct 2025

Cracking the Code of T Cell Expansion Inside Tumors

The ability of immune cells-particularly CD8+ T cells-to launch a rapid burst of proliferation inside tumors is key to the success of modern day cancer immunotherapies.

22 Oct 2025

Croatian Scientists Rewrite the Story of Cell Division

Scientists at the Ruđer Bošković Institute (RBI) in Zagreb, Croatia, have discovered that the protein CENP-E, long believed to act as a motor dragging chromosomes into place during cell division, in fact plays a completely different role in chromosome movement.

22 Oct 2025

Disarming Cancer’s Droplet Hubs to Halt Tumor Growth

In a city, coworking hubs bring people and ideas together. Inside cancer cells, similar hubs form-but instead of fueling progress, they supercharge disease. That's what researchers at the Texas A&M University Health Science Center (Texas A&M Health) have discovered inside the cells of a rare and aggressive kidney cancer.

21 Oct 2025

Decoding the Genetic Network Behind Soybean Shade Tolerance

In intercropping systems, soybeans grown beneath tall maize plants experience severe shading that disrupts photosynthesis, weakens stems, and limits yield.

21 Oct 2025

Serotonin-Producing Gut Microbes May Hold the Key to Treating IBS

Research from the University of Gothenburg, Sweden, clarifies the complex interaction between gut bacteria and IBS.

21 Oct 2025

Autophagy Protein ATG9A Shields the Skin from Harmful Inflammation

Researchers at VIB and Ghent University have uncovered a key mechanism that protects the skin from harmful inflammation.

21 Oct 2025

Innovative Fluorescent Technique Sheds Light on Cellular Lipid Transport

Lipids are fatty molecules that play critical roles in cell function, including membrane structure, energy storage and nutrient absorption.

17 Oct 2025

Synthetic Biology Unlocks New Ways to Engineer Plant–Microbe Interactions

By integrating engineering principles with plant biology, this review highlights how redesigned genetic pathways and plant-based biosensors can deepen understanding of plant responses to both harmful and beneficial microbes.

17 Oct 2025

Cancer Reawakens Embryonic Gene Editors to Fuel Tumor Growth

Cancer cells are known to reawaken embryonic genes to grow. A new study reveals the disease also hijacks the proteins, or "editors", that control how those genes are read.

17 Oct 2025

Molecular Brake SlKNU Regulates Flower Formation and Fruit Development in Tomato

Floral meristems (FMs) are small clusters of stem cells that orchestrate flower formation and ultimately determine the size and structure of the fruit.

17 Oct 2025

Study Uncovers Hundreds of New Viruses Living Inside the Gut Bacteria

Hundreds of new viruses living inside bacteria within our gut have been discovered in an international study led by Professor Jeremy J. Barr from Monash University's School of Biological Sciences and Associate Professor Sam Forster from Hudson Institute of Medical Research.

16 Oct 2025