Fibroblast News and Research

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Fibroblasts are connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.

Severe lung injuries can trigger stem cells to undergo abnormal differentiation, study finds

Severe injuries to the lung from diseases such as COVID-19 trigger abnormal stem cell repair that alters the architecture of the lung. The aberrant stem cell differentiation in response to injury can prevent the restoration of normal lung function.

31 Dec 2021

Study imparts mechanistic understanding on early stages of human cancer

Scientists demonstrated that normal human fibroblast cells can be converted to specific cancer cells through factors that are identified in actual human patients.

9 Sep 2021

Specific subset of fibroblast cells could provide protection from debilitating lung disease

Single-cell RNA sequencing has revealed a subset of cells that could provide protection from a rare, but severely debilitating and fatal, lung disease.

16 Jul 2021

Induced pluripotent stem cells show promise to revive wildlife species

A new article shares a significant development in conservation—one that may make the difference between extinction and survival for wildlife species.

23 Feb 2021

Study shows how brain protein helps pancreatic cancer cells to survive

Researchers have discovered that a protein thought to only be involved in the development of neurons in the brain also plays a major role in the development and growth of pancreatic cancer.

19 Nov 2020

Researchers identify protein that causes adverse side effects in gastric cancer patients

Gastric cancer is one of the major causes of cancer-related mortality around the world. It is known for its potential to spread across the peritoneal cavity.

1 Sep 2020

Study shows how high-protein diet protects against fatty liver

Non-alcoholic fatty liver disease is the most common chronic liver disease in the world, with sometimes life-threatening consequences.

19 Aug 2020

Study indicates a powerful treatment for pulmonary fibrosis

A pre-clinical study led by scientists at Cincinnati Children's demonstrates that in mice the drug barasertib reverses the activation of fibroblasts that cause dangerous scar tissue to build up in the lungs of people with idiopathic pulmonary fibrosis (IPF).

7 Aug 2020

Study sheds new light on core regulatory networks that govern cell types in vertebrates

The FANTOM Consortium has shed new light into the main regulatory networks that govern the types of cells found in different vertebrate species.

29 Jul 2020

Researchers identify how airway cells work together in regeneration and aging

Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have identified the process by which stem cells in the airways of the lungs switch between two distinct phases -- creating more of themselves and producing mature airway cells -- to regenerate lung tissue after an injury.

28 Jul 2020