Chromatin News and Research

RSS

How 3D DNA Architecture Shapes Cell Fate in Early Embryos

The intricate process of duplicating genetic information, referred to as DNA replication, lies at the heart of the transmission of life from one cell to another and from one organism to the next. This happens by not just simply copying the genetic information; a well-orchestrated sequence of molecular events has to happen at the right time.

21 Dec 2023

Non-Invasive Early Cancer Detection Using Chromatin Signatures in Mononuclear Blood Cells

Blood cells reveal tumors in the body. Researchers at the Paul Scherrer Institute achieve an advance with the development of a test for early diagnosis of cancer.

18 Dec 2023

Unraveling the Complexities of Gene Regulation with MAbID

A novel technique named MAbID, developed by researchers led by Jop Kind, has been introduced to concurrently investigate various mechanisms of gene regulation, crucial for both development and disease processes.

5 Dec 2023

Scientists Discover New Class of Molecular Glue Degraders for Cancer Therapy

Cells contain molecular machinery that targets and disposes of unwanted proteins to maintain homeostasis.

17 Nov 2023

New Model Reveals How Cells Maintain Epigenetic Memory During Cell Division

Every cell in the human body contains the same genetic instructions, encoded in its DNA. However, out of about 30,000 genes, each cell expresses only those genes that it needs to become a nerve cell, immune cell, or any of the other hundreds of cell types in the body.

17 Nov 2023

Unveiling the Role of Foxp3 in Shaping Chromatin Architecture of Regulatory T Cells

Regulatory T cells, or Tregs, represent a specialized class of immune cells dedicated to quelling immune responses and safeguarding the body against self-attack.

7 Nov 2023

DNA Methylation Enables Plants Adapt in a Warm World

Plants increasingly need to adapt quickly to preserve their existence as global warming continues to reshape ecosystems.

13 Oct 2023

DNA Aptamer Promotes Cardiomyocyte Differentiation From Pluripotent Stem Cells

Generating specific cell lineages from induced pluripotent stem cells and embryonic stem cells is the holy grail of regenerative medicine.

12 Oct 2023

Epigenetic Regulator MOF Plays Critical Role in Mitochondrial Function

The intricate control of cellular metabolism relies on the coordinated and harmonious interplay between the nucleus and mitochondria.

10 Oct 2023

Effectiveness of SCID-X1 Gene Therapy Influenced by 3D Genome Architecture

Patients with X-linked severe combined immunodeficiency disorder (SCID-X1), often known as “bubble boy disease,” are born with a faulty gene that inhibits immune cells from being produced.

9 Oct 2023

Study Links Autism Gene to Broad Spectrum of Molecular and Cellular Defects

Researchers have used CRISPR gene editing, stem cells and human neurons to study the impact of a gene that is commonly mutated in autism.

6 Oct 2023

The Astute White Blood Cell Defense

Neutrophils, the most prevalent kind of white blood cell, are able to block Candida albicans toxin, according to study from Umeå University. EMBO Reports has published the findings.

6 Oct 2023

New Insights into the Role of Intrinsically Disordered Regions in Chromatin Biology

According to textbooks, proteins work by folding into stable 3D shapes that, like Lego blocks, precisely fit with other biomolecules.

3 Oct 2023

New Halophyte Genome Sequence Sheds Light on Salt Tolerance Mechanisms

A Recent study conducted by Professor Qin Yuan's team from the Center for Genomics at the Haixia Institute of Science and Technology (Future Technology College) at Fujian Agriculture and Forestry University has been published in the prestigious journal Horticulture Research, which is a leading publication in the field of horticultural science.

25 Sep 2023

Study Reports High-Resolution Structures of CAF-1

Since the passage of the DNA replication fork destroys nucleosomes on the DNA, chromatin inheritance during cell division requires the replication of DNA and the assembling of nucleosomes onto the duplicated DNA.

28 Aug 2023

NSL Complex Regulates Intraciliary Transport Genes in Multiple Cell Types

The non-specific lethal (NSL) complex is a chromatin-associated factor that has been shown in both fruit flies and mammals to regulate the expression of thousands of genes. Abrogation of the NSL genes causes the organism to die, which gives rise to the complex’s unusual name.

28 Aug 2023

Researchers Shed Light on Complex Interplay Between Taste Perception and Immune Function

A bitter taste in the mouth is often a symptom or side effect of illness, which may be the result of how the body reacts to pathogens. A new study published in iScience, by Hong Wang, PhD, an Associate Member at the Monell Chemical Sense Center, and colleagues sheds light on the mechanisms involved in the complex interplay between taste perception and immune function.

25 Aug 2023