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New High-Throughput Platform for Rapid Evaluation of Plant-Derived Molecules

Plants are powerhouses of molecular manufacturing. Over the eons, they have evolved to produce a plethora of small molecules -; some are beneficial and valuable to humans, others can be deadly.

28 Jun 2024

New Tool IMPRINT Enhances DNA Transformation in Various Bacterial Strains

Bacteria, with their unique capabilities, hold immense promise for improving various aspects of the world.

27 Jun 2024

Unveiling a Reversible Pre-Commitment Stage in Cell Division

Researchers at Weill Cornell Medicine have uncovered a surprising new step in cell division.

27 Jun 2024

Bridge RNA: The Revolutionary Tool in Genetic Recombination

In a leap forward for genetic engineering, a team of researchers from the Arc Institute have discovered the bridge recombinase mechanism, a precise and powerful tool to recombine and rearrange DNA in a programmable way.

27 Jun 2024

Fruit Fly Motor Circuitry Revealed Through Advanced Mapping Techniques

Work is underway on a wiring diagram of the motor circuits in the central nervous system that control muscles in fruit flies.

27 Jun 2024

Study Highlights MSC-EVs Potential for Alleviating Lung Fibrosis

Pulmonary fibrosis (PF) is a chronic interstitial lung disease characterized by fibroblast proliferation and extracellular matrix formation, causing structural damage and lung failure.

27 Jun 2024

Breakthrough in Understanding Connexin-Drug Interactions

Researchers have gained new knowledge of how drugs bind to connexin molecules. These molecules form channels that allow neighboring cells to send direct messages to one another.

27 Jun 2024

One Size Doesn't Fit All: Study Reveals Stark Sex Differences in Mitochondrial Activity

Study comparing the genetic activity of mitochondria, the cell’s power plants, in males and females finds extreme differences, suggesting certain disease therapies must be tailored to each sex.

26 Jun 2024

Mapping Gene Targets of HNF4A and HNF1A in Human Pancreatic Beta Cells and Liver Cells

Scientists have generated a comprehensive map of the gene targets regulated by the transcription factors HNF4A and HNF1A in human pancreatic beta cells and liver cells.

26 Jun 2024

New Insights into How Cells Fine-Tune Protein Assembly

Imagine the body as a bustling factory constantly assembling proteins, the building blocks that keep everything running smoothly.

26 Jun 2024

Scientists Identify Gene Region that Fuels Asthma Inflammation

Pollen and house dust mites are two common allergens that cause respiratory distress in asthma patients. But type-2 helper T (Th2) cells and group-2 innate lymphoid cells (ILC2s) release a class of proteins known as type-2 cytokines in response to a variety of asthma triggers. GATA-binding protein 3 (GATA3) is essential for the maturation of Th2 and ILC2.

25 Jun 2024

CRISPR-Derived Protein Controls Exon Inclusion and Exclusion

The University of Toronto researchers have successfully and precisely controlled the process of RNA splicing by using CRISPR, a bacterial immune defense system.

25 Jun 2024

High-resolution 3D maps of diseased tissues at the subcellular level

Molecular maps from patient tissue samples can be created with subcellular precision using an open-source platform created by researchers in the lab of Nikolaus Rajewsky at the Max Delbrück Center. This allows for in-depth analysis and may improve routine clinical pathology. The research was published in the journal Cell.

25 Jun 2024

Using iPSC-Derived Cardiomyocytes to Uncover Mechanisms of Hypertrophic Cardiomyopathy

Using animals to study heart disease doesn't always translate well to human health outcomes, and human heart cells available for research don't work outside the human body.

25 Jun 2024

AI-Based Approach Revolutionizes Protein Interaction Prediction

Proteins are the building blocks of life, involved in virtually every biological process.

25 Jun 2024

Primitive Endoderm Stem Cells Offer New Hope for Fertility Treatments

An unexpectedly versatile and regenerative stem cell in early embryos may be key to creating new effective fertility treatments, suggests a new study in mice from the University of Copenhagen.

25 Jun 2024

Unlocking the Role of Antisense RNA as a Gene Expression Booster

The function of non-coding RNA in the cell has long been a mystery to researchers. Unlike coding RNA, non-coding RNA does not produce proteins – yet it exists in large quantities.

25 Jun 2024

Genetic Influences on Lifespan Variance and Healthspan in Caenorhabditis elegans

Why do some people live for longer than others? The genes in our DNA sequence are important, helping avoid disease or maintain general health, but differences in our genome sequence alone explain less than 30% of the natural variance of human life expectancy.

25 Jun 2024

AI-Driven Design of Soluble Protein Analogs for Drug Discovery and Antibody Development

Many drug and antibody discovery pathways focus on intricately folded cell membrane proteins: when molecules of a drug candidate bind to these proteins, like a key going into a lock, they trigger chemical cascades that alter cellular behavior.

24 Jun 2024

Small Molecule Restores TERT Levels to Combat Aging-Related Decline

Researchers at The University of Texas MD Anderson Cancer Center have demonstrated that therapeutically restoring 'youthful' levels of a specific subunit of the telomerase enzyme can significantly reduce the signs and symptoms of aging in preclinical models.

24 Jun 2024