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Whole genome sequencing might help better assess tumor evolution

To develop the most efficacious, personalized treatment plans for patients with Hodgkin lymphoma or other cancers, researchers and clinicians must first understand the genetic changes that cause cancer to develop.

23 Feb 2023

Robust method for induced pluripotent stem cell culture

Different types of cells, such as the heart, liver, blood, and sperm cells, have characteristics that help them perform their specific functions in the body. In general, those traits are hard-wired. A heart cell will not randomly transform into a liver cell if not stimulated.

23 Feb 2023

Limiting antibiotic use in livestock associated with reduction in antibiotic-resistant infection

A California policy restricting antibiotic use in animals raised for food is associated with a reduction in one type of antibiotic-resistant infection in people in the state, according to a new study published today in the journal Environmental Health Perspectives.

23 Feb 2023

Mount Sinai researchers reveal mechanisms underlying autoimmunity in Down syndrome

Scientists at the Icahn School of Medicine at Mount Sinai in New York have identified which parts of the immune system go awry and contribute to autoimmune diseases in individuals with Down syndrome.

23 Feb 2023

Mount Sinai researchers illuminate the role of DNA methylation in Alzheimer's disease

Mount Sinai researchers have published a study in Alzheimer's & Dementia: The Journal of the Alzheimer's Association that sheds new light on the role of DNA methylation in Alzheimer's disease (AD).

23 Feb 2023

Monitoring bovine meat and milk factor protein expression could enable colorectal cancer detection

Bovine meat and milk factors (BMMFs)-; initially identified by de Villiers et al. in 2014-; represent a class of infectious agents in beef and cow's milk that have been linked to the development of cancer.

23 Feb 2023

Study shows how convalescent plasma can be used as effective treatment during future pandemics

Three years into the COVID-19 pandemic, new variant outbreaks continue to fuel economic disruptions and hospitalizations across the globe.

22 Feb 2023

Adults struggling with chronic constipation benefit from a vibrating capsule

A vibrating capsule designed to stir the colon to action appears to double the ability for adults struggling with debilitating chronic constipation to defecate more normally and without drugs, researchers report.

22 Feb 2023

New host protease determinants facilitating the infection of SARS-CoV-2 identified

Researchers from Department of Microbiology, School of Clinical Medicine, LKS Faculty of Medicine, the University of Hong Kong (HKUMed), has identified novel host protease determinants, that facilitate the infection of SARS-CoV-2, including the Omicron variant, which provided new targets for combating the pandemic.

22 Feb 2023

Role of probiotics and functional materials in the treatment of intestinal inflammation

Maintenance of sulfomucin is a key end point in the treatment of diarrhea and inflammatory bowel disease (IBD). However, the mechanism underlying the microbial sense to sulfomucin are poorly understood, and to date, there are no therapies targeting the secretion and maturation of sulfomucin in IBD. Considering the important role of gut microbiota in host immune regulation, maintain sulfomucin by modulating the gut microbiota is inspired.

20 Feb 2023

Revealing a novel form of ferroptosis that may be implicated in diseases caused by acute injury

This study is led by Dr. Anjian Xu (Beijing Clinical Research Institute, Beijing Friendship Hospital, Capital Medical University), Dr. Min Cong (Liver Research Center, Beijing Friendship Hospital, Capital Medical University) and Dr. Junying Ding (Beijing Key Laboratory of Basic Research with Traditional Chinese Medicine on Infectious Diseases, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University).

20 Feb 2023

Identifying antimicrobials that effectively treat AMR infections

In a potential game changer for the treatment of superbugs, a new class of antibiotics was developed that cured mice infected with bacteria deemed nearly "untreatable" in humans -; and resistance to the drug was virtually undetectable.

19 Feb 2023

"Poisoned" form of a protein could set off events that encourage cancer growth

Scientists at Scripps Research, with collaborators in Japan, have discovered how a "poisoned" form of a protein could set off a cascade of events that encourage the growth of some cancers.

17 Feb 2023

Extended generation of blood cells in wild-type animals from pluripotent stem cells

Cells present in the blood like red blood cells, immune cells, and other crucial cell types are renewed continually from stem cells, the alleged hematopoietic stem and progenitor cells (HSPCs).

17 Feb 2023

Improved efficacy of advanced genome editing with machine learning

Researchers at the Wellcome Sanger Institute have developed a new tool to estimate the probability of successfully introducing a gene-edited DNA sequence into a cell’s genome using the prime editing method.

17 Feb 2023

Substituting meat for mycoprotein reduces intestinal genotoxins, increases healthy gut bacteria

Researchers from Northumbria University have found that swapping red and processed meat for Quorn's mycoprotein, a fungi-based meat alternative, leads to a significant reduction in intestinal genotoxins - which can cause bowel cancer - and increases healthy gut bacteria.

17 Feb 2023

Developing a potential drug molecule that targets STAT5

STAT5 has generally been recognized as an enticing cancer target, but after years of research, it was downgraded to the “undruggable” category. Now, scientists at the University of Michigan Rogel Cancer Center have achieved success with a novel approach.

17 Feb 2023

Study identifies cell type crucial for successful immunotherapies for chronic viral infections

An international study led by researchers from the Infection Biology Laboratory at the UPF Department of Medicine and Life Sciences (MELIS) establishes that one type of dendritic cells is crucial for the success of immunotherapeutic treatments to control chronic viral infections.

17 Feb 2023

Reversal of ADAR1 hyper-editing with small molecule inhibitor

Researchers at University of California San Diego School of Medicine, Sanford Stem Cell Institute and Moores Cancer Center report that a late-stage, pre-clinical small molecule inhibitor, called rebecsinib, reverses malignant hyper-editing by an inflammation-induced protein isoform, known as ADAR1 p150.

17 Feb 2023

NIH researchers release new tool to assemble complete genome sequences on-demand

National Institutes of Health researchers have developed and released an innovative software tool to assemble truly complete (i.e., gapless) genome sequences from a variety of species.

17 Feb 2023

Clinical News and Research

Whole genome sequencing might help better assess tumor evolution

Robust method for induced pluripotent stem cell culture

Limiting antibiotic use in livestock associated with reduction in antibiotic-resistant infection

Mount Sinai researchers reveal mechanisms underlying autoimmunity in Down syndrome

Mount Sinai researchers illuminate the role of DNA methylation in Alzheimer's disease

Monitoring bovine meat and milk factor protein expression could enable colorectal cancer detection

Study shows how convalescent plasma can be used as effective treatment during future pandemics

Adults struggling with chronic constipation benefit from a vibrating capsule

New host protease determinants facilitating the infection of SARS-CoV-2 identified

Role of probiotics and functional materials in the treatment of intestinal inflammation

Revealing a novel form of ferroptosis that may be implicated in diseases caused by acute injury

Identifying antimicrobials that effectively treat AMR infections

"Poisoned" form of a protein could set off events that encourage cancer growth

Extended generation of blood cells in wild-type animals from pluripotent stem cells

Improved efficacy of advanced genome editing with machine learning

Substituting meat for mycoprotein reduces intestinal genotoxins, increases healthy gut bacteria

Developing a potential drug molecule that targets STAT5

Study identifies cell type crucial for successful immunotherapies for chronic viral infections

Reversal of ADAR1 hyper-editing with small molecule inhibitor

NIH researchers release new tool to assemble complete genome sequences on-demand

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