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The human brain is the center of the human nervous system and is a highly complex organ. Enclosed in the cranium, it has the same general structure as the brains of other mammals, but is over three times as large as the brain of a typical mammal with an equivalent body size.

Study: REAER is a promising therapy for improving the lives of patients with multiple sclerosis

A team of multiple sclerosis (MS) experts at Kessler Foundation led the first pilot randomized controlled trial of robotic-exoskeleton assisted exercise rehabilitation (REAER) effects on mobility, cognition, and brain connectivity in people with substantial MS-related disability.

31 May 2021

Neuromorphic chip recognizes complex biosignals, can help monitor epilepsy

Current neural network algorithms produce impressive results that help solve an incredible number of problems.

27 May 2021

Light-controlled on/off switch can help reset the biological clock

The biological clock is present in almost all cells of an organism. As more and more evidence emerges that clocks in certain organs could be out of sync, there is a need to investigate and reset these clocks locally.

26 May 2021

Researchers suggest new strategies for finding drugs that neutralize key enzymes

Scientists from the UK's University of Bath explore racemases - an important type of enzyme that is linked to certain cancers and other life-threatening diseases while also being critical to cell function - in a paper published in the prestigious journal Chemical Society Reviews. The scientists also propose new strategies for finding drugs that neutralize these enzymes.

From University of Bath 26 May 2021

Latest articles provide novel insights into the mechanisms driving pridopidine neuroprotective effects

Prilenia Therapeutics B.V., a clinical stage biotech company focused on developing novel treatments for neurodegenerative and neurodevelopmental disorders, today announces the publication of three peer-reviewed journal articles, highlighting key aspects of the mechanism of action of its lead asset, pridopidine, and the importance of S1R activation as a mechanism to attenuate biological features of neurodegenerative diseases.

25 May 2021

“Paralyzed” immune cells can be reactivated by drugs in IDH-mutant gliomas

Brain tumor cells with a certain common mutation reprogram invading immune cells. This leads to the paralysis of the body's immune defense against the tumor in the brain. Researchers from Heidelberg, Mannheim, and Freiburg discovered this mechanism and at the same time identified a way of reactivating the paralyzed immune system to fight the tumor.

25 May 2021

Gene expression signatures underlying microglia linked with amyloid plaque phagocytosis

Alzheimer’s disease is the most prevalent form of dementia distinguished by the accumulation of amyloid plaques in the brain.

24 May 2021

Lithium concentration in the brains of depressed people varies from healthy people

Depressive diseases are among the most common illnesses in the world.

24 May 2021

Study shows how mitochondrial function impacts schizophrenia in patients with genetic disorder

Researchers have demonstrated how cell “batteries” play a significant role in whether patients with the chromosomal deletion syndrome acquire schizophrenia.

20 May 2021

Researchers gain new insights into the physiological functions of APP protein

The pivotal role played by the APP protein in Alzheimer’s disease is well known.

20 May 2021

Study identifies DNA alterations that underpin brain and cognitive decline in the elderly

According to a new mathematical model published recently in eLife, Alzheimer’s disease has some important similarities with healthy aging.

20 May 2021

Novel peptide could allow cannabis to relieve pain while avoiding side effects

Many people live with chronic pain, and in some cases, cannabis can provide relief. But the drug also can significantly impact memory and other cognitive functions.

13 May 2021

New method can enable early detection and treatment of cerebral aneurysms

Cerebral aneurysms are malformations caused by abnormalities on the walls of blood vessels in the brain. When these blood vessels rupture, about 30% of the sufferers die on the spot, giving these the rightful label of 'ticking bombs in the head'.

11 May 2021

Study: Individuals who recovered from depression had increased level of serotonin transporter

Low levels of serotonin in the brain are seen as a possible cause of depression and many antidepressants act by blocking a protein that transports serotonin away from the nerve cells.

11 May 2021

Study unravels the role of proteins in data processing in the brain

For data to travel from one nerve cell to the next, a complex association between different proteins is necessary.

10 May 2021

AI-integrated microscopes perform quicker imaging and handle more data

Scientists have begun using a method known as light-field microscopy to capture rapid biological processes in 3D to identify the neuronal signals in a fish brain.

10 May 2021

Lack of functional GAS2 gene causes severe hearing impairment in mice

A gene called GAS2 plays a key role in normal hearing, and its absence causes severe hearing loss, according to a study led by researchers in the Perelman School of Medicine at the University of Pennsylvania.

10 May 2021

Researchers map unique genetic profile of osteocytes for the first time

Researchers have mapped the specific genetic profile of the skeleton’s “master regulator” cells, called osteocytes, for the first time.

7 May 2021

Researchers devise a small-molecule cocktail to protect stem cells from stress

Researchers at the National Institutes of Health (NIH) have devised a four-part small-molecule cocktail that can protect stem cells called induced pluripotent stem cells (iPSCs) from stress and maintain normal stem cell structure and function.

4 May 2021

New integrative genetic screening technology offers insights into role of DNA accessibility in cancer

In a new resource for the scientific community, published today in Nature Biotechnology, researchers in the lab of Neville Sanjana, PhD, at the New York Genome Center (NYGC) and New York University (NYU) developed CRISPR-sciATAC, a novel integrative genetic screening platform that jointly captures CRISPR gene perturbations and single-cell chromatin accessibility genome-wide.

30 Apr 2021

Brain News and Research

Study: REAER is a promising therapy for improving the lives of patients with multiple sclerosis

Neuromorphic chip recognizes complex biosignals, can help monitor epilepsy

Light-controlled on/off switch can help reset the biological clock

Researchers suggest new strategies for finding drugs that neutralize key enzymes

Latest articles provide novel insights into the mechanisms driving pridopidine neuroprotective effects

“Paralyzed” immune cells can be reactivated by drugs in IDH-mutant gliomas

Gene expression signatures underlying microglia linked with amyloid plaque phagocytosis

Lithium concentration in the brains of depressed people varies from healthy people

Study shows how mitochondrial function impacts schizophrenia in patients with genetic disorder

Researchers gain new insights into the physiological functions of APP protein

Study identifies DNA alterations that underpin brain and cognitive decline in the elderly

Novel peptide could allow cannabis to relieve pain while avoiding side effects

New method can enable early detection and treatment of cerebral aneurysms

Study: Individuals who recovered from depression had increased level of serotonin transporter

Study unravels the role of proteins in data processing in the brain

AI-integrated microscopes perform quicker imaging and handle more data

Lack of functional GAS2 gene causes severe hearing impairment in mice

Researchers map unique genetic profile of osteocytes for the first time

Researchers devise a small-molecule cocktail to protect stem cells from stress

New integrative genetic screening technology offers insights into role of DNA accessibility in cancer

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