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Study examines the largest and most diverse genetic sequencing data sets

Researchers at the University of Maryland School of Medicine (UMSOM) and their colleagues published a new analysis today in the journal Nature from genetic sequencing data of more than 53,000 individuals, primarily from minority populations.

11 Feb 2021

Study shows strong link between genetic changes and cerebral palsy

Scientists have identified a strong connection between genetic modifications known to cause cerebral palsy and neurodevelopmental disabilities.

3 Feb 2021

Scientists discover the origin of rare genetic syndrome

Improvements in DNA sequencing have revealed a rare syndrome triggered by changes in the SATB1gene.

29 Jan 2021

Innovative gene therapy approach for regeneration of functional new neurons

Spinal cord injury (SCI) often causes disability and seriously compromises quality of life. While decades of research have made significant progress in axonal regeneration after SCI, most of the interventions have not been translated into clinical therapies.

18 Dec 2020

Scientists successfully edit SIV virus from genomes of non-human primates

Taking a major step forward in HIV research, scientists at the Lewis Katz School of Medicine at Temple University have successfully edited SIV - a virus closely related to HIV, the cause of AIDS - from the genomes of non-human primates.

1 Dec 2020

Environmental risk factors are important determinants of cardiovascular disease

In a current opinion article "Reduction of environmental pollutants for prevention of cardiovascular disease: it's time to act", published in the European Heart Journal this week.

9 Nov 2020

SARS-Cov-2 spike proteins can directly impact the function of blood-brain barrier

Like a key, SARS-CoV-2 - the virus that causes coronavirus disease 2019 (COVID-19) - attaches to specific molecules on the host cell surface, opening gateways into the cell interior.

30 Oct 2020

Researchers uncover a new cellular mechanism for disposing of misfolded proteins

About 30 years ago, Dr. Richard Sifers set out on a journey to discover why people with a rare condition known as alpha1-antitrypsin (AAT) deficiency present with high variation in the severity of liver disease.

21 Oct 2020

Study reveals molecular mechanism that regulates filament-like proteins in heart muscles

Heart muscle cells contain filament-like proteins that should have the same precise length, so that they can perfectly synchronize.

15 Oct 2020

Study confirms genetic link in cerebral palsy

A research team has found further evidence that rare gene mutations can cause cerebral palsy, findings which could lead to earlier diagnosis.

8 Oct 2020

Study reveals new gene involved in motor neuron diseases

According to a study, failures in a quality control system that defends protein-building fidelity in cells can result in motor neuron degeneration.

18 Sep 2020

Mice study shows naturally-occurring metabolite improves longevity

According to results from a study, middle-aged mice had a better “old age” when the naturally-occurring metabolite, called AKG, was added to their food.

2 Sep 2020

How do Neural Stem Cells become Nerve Cells?

Professor Vanderhaeghen speaks to AZoLifeSciences about his teams research discovery on mitochondria, and their involvement during brain development.

1 Sep 2020

Study reveals key biomolecule that can heal damaged heart tissues

When a person suffers a heart attack, parts of the heart can become stiff and scarred, leading to disability and possible progression toward heart failure.

26 Aug 2020

Re-designed natural enzyme shows promise in promoting the regrowth of nerve tissue injury

A team of researchers from University of Toronto Engineering and the University of Michigan has redesigned and enhanced a natural enzyme that shows promise in promoting the regrowth of nerve tissue following injury.

From University of Toronto 25 Aug 2020

Researchers develop new drugs to eradicate parasitic worms

In this breakthrough method, parasitic worms are prevented from using alternative metabolism routes offered by microbes living inside them.

12 Aug 2020

Aspirin may increase risk of disease progression in older adults with advanced cancer

Results from a recent clinical trial indicate that for older adults with advanced cancer, initiating aspirin may increase their risk of disease progression and early death.

11 Aug 2020

Novel therapeutics targeting primary cilia may reverse neurodevelopmental disorders

Primary cilia are structures that act like antennas for cells to identify signals and occur less in mice affected by Fragile X syndrome since birth.

31 Jul 2020

Virginia Tech scientists reveal molecular cause underlying rare genetic disorder

Virginia Tech scientists have revealed how a nonfunctioning version of an ordinary gene impairs brain structure and function. The findings help explain a genetic form of microcephaly -- a condition where babies' heads are small and grow more slowly than their peers.

28 Jul 2020

New radiotracer provides a quantitative measure of disease progression after stroke

A new radiotracer, 18F-SynVesT-2, can directly assess synaptic density changes in the brain, providing an objective and quantitative measure of disease progression after stroke.

14 Jul 2020