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High diversity in T-cell receptor genes explains diverse response to infections

Researchers from Karolinska Institutet have demonstrated that the genes that encode the T cell receptors change significantly between individuals and communities, which could help explain why people react differently to certain diseases.

17 Feb 2023

Developing a potential drug molecule that targets STAT5

STAT5 has generally been recognized as an enticing cancer target, but after years of research, it was downgraded to the “undruggable” category. Now, scientists at the University of Michigan Rogel Cancer Center have achieved success with a novel approach.

17 Feb 2023

Study identifies cell type crucial for successful immunotherapies for chronic viral infections

An international study led by researchers from the Infection Biology Laboratory at the UPF Department of Medicine and Life Sciences (MELIS) establishes that one type of dendritic cells is crucial for the success of immunotherapeutic treatments to control chronic viral infections.

17 Feb 2023

Digital microfluidics as the optimal technology for bacterial protocol advances

The February 2023 issue of SLAS Technology contains a set of four original research articles and one review article covering digital microfluidics (DMF), cryopreservation, colorectal cancer research and other laboratory automation technology.

17 Feb 2023

Reversal of ADAR1 hyper-editing with small molecule inhibitor

Researchers at University of California San Diego School of Medicine, Sanford Stem Cell Institute and Moores Cancer Center report that a late-stage, pre-clinical small molecule inhibitor, called rebecsinib, reverses malignant hyper-editing by an inflammation-induced protein isoform, known as ADAR1 p150.

17 Feb 2023

New approach to rapidly determine biological aging

Telomeres-;the caps at the ends of chromosomes that protect our genetic materials from the brunt of cellular wear and tear-;are known to shorten and fray over time.

16 Feb 2023

B lymphocytes stimulate the in-demand production of innate immune cells during infection

An SOS signals a call for immediate action during an emergency to request a need for protection. The immune system, a network of defense mechanisms, enhances protection to recover the body's internal stability.

16 Feb 2023

New approach to better target cellular proteins

By studying how enzymes move from one membrane compartment to another inside a cell, scientists at the University of Illinois Chicago have figured out a way to better target cellular proteins, which play a role in many diseases.

16 Feb 2023

New center at UCLA focuses on the microbiome’s role in disease prevention

Among the most promising areas of scientific inquiry is the study of the human microbiome and its effect on health. To fuel more rapid progress in this field, Andrea and Donald Goodman and Renee and Meyer Luskin have made a $20 million gift to establish the UCLA Goodman–Luskin Microbiome Center.

16 Feb 2023

An innovative strategy for on-demand contraception for men

An experimental contraceptive drug developed by Weill Cornell Medicine investigators temporarily stops sperm in their tracks and prevents pregnancies in preclinical models. The study, published in Nature Communications on Feb. 14, demonstrates that an on-demand male contraceptive is possible.

16 Feb 2023

Novel mechanism of DNA repair occurring in neurons uncovered

"Use it or lose it" goes the adage, applied liberally to everything from our muscles to our minds, especially as we age.

16 Feb 2023

LJI receives funding from NIAID to lead the biggest human immunoprofiling effort

A new grant of over $17 million from the National Institute of Allergy and Infectious Diseases (NIAID) has established La Jolla Institute for Immunology (LJI) as the leading institute for human immunology data curation, analysis, and dissemination. With this funding, LJI has taken the helm of the Human Immunology Project Consortium Data Coordinating Center, a critical tool in the effort to fuel scientific collaboration in immunoprofiling and highlight findings from the overall Human Immunology Project Consortium (HIPC).

16 Feb 2023

The essential protein needed for immune evasion and tumor cell metabolism

Typically, tumor cells change their energy metabolism and take in more glucose to enable their rapid division and spread. As a result, the body’s immune response to cancer is suppressed by limiting the immune cells’ access to glucose.

15 Feb 2023

IGSF3-mediated potassium dysregulation drives glioma-related epilepsy

Glioma is one of the most aggressive malignant primary brain tumors. A common feature of glioma is the presence of localized, intermittent seizures referred to as glioma-related epilepsy, which is known to promote tumor growth. However, the mechanism involved at the molecular level is still not clear.

15 Feb 2023

Inhibiting astrocyte hyperactivity can reverse cognitive deficits associated with social deprivation

Here is an important reason to stay in touch with friends and family: social isolation causes memory and learning deficits and other behavioral changes.

15 Feb 2023

MD Anderson and Replay launch new company pioneering T cell receptor NK cell therapies

The University of Texas MD Anderson Cancer Center and Replay today announced the launch of Syena, a new oncology-focused product company pioneering T cell receptor (TCR) natural killer (NK) cell therapies.

15 Feb 2023

Analyzing the immune microenvironment around Hodgkin lymphoma tumors

The most detailed study of Hodgkin lymphoma, a type of blood cancer, has offered considerable insight into what tumor cells must do to sustain. The Wellcome Sanger Institute discovered that cancer cells utilize signals to attract specific types of immune cells and direct them not to attack.

15 Feb 2023

Versatile molecular toolbox expands the scope of gene regulation

Rice University scientists have enlisted widely used cancer therapy systems to control gene expression in mammalian cells, a feat of synthetic biology that could change how diseases are treated.

15 Feb 2023

Climate change likely to help mosquitoes reach colder parts of the continent

Based on data that span the past 120 years, scientists at Georgetown University Medical Center have found that the mosquitoes responsible for transmitting malaria in Africa are spreading deeper into southern Africa and to higher elevations than previously recorded. The researchers estimate that Anopheles mosquito populations in sub-Saharan Africa have gained an average of 6.5 meters (21 feet) of elevation per year, and the southern limits of their ranges moved south of the equator by 4.7 kilometers (nearly 3 miles) per year.

15 Feb 2023

New ways to diagnose learning and memory disorders

By showing Welles's movie "Touch of Evil" to mice, Chinmay Purandare, PhD, and Prof. Mayank Mehta of UCLA have uncovered surprising and important new insights about how neurons form memories. The discovery points to new ways to diagnose Alzheimer's and other learning and memory impairments, while also improving artificial intelligence.

15 Feb 2023