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Researchers Discover Novel Clubroot Resistance Gene Crr5 in Chinese Cabbage

Clubroot disease, caused by Plasmodiophora brassicae, is a devastating soil-borne pathogen that severely threatens global production of cruciferous crops.

28 Oct 2025

Research Pinpoints HMGN1 as Cause of Trisomy 21-Related Heart Abnormalities

Three copies of chromosome 21 causes Down syndrome (DS), and roughly half of children born each year in the United States with DS-approximately 2,600-also have congenital heart defects (CHDs).

23 Oct 2025

Decoding the Genetic Network Behind Soybean Shade Tolerance

In intercropping systems, soybeans grown beneath tall maize plants experience severe shading that disrupts photosynthesis, weakens stems, and limits yield.

21 Oct 2025

RyR1-Mediated CICR Plays Minimal Role in Normal Skeletal Muscle Contraction

Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release.

26 Sep 2025

Honeybee Food-Sharing Genes Linked to Human Social Behavior

The study links genetic variation to honeybee sociability, revealing insights into food-sharing behavior and its evolutionary significance in social networks.

25 Sep 2025

The First Parent-Of-Origin Gene Atlas of The Mammary Gland

This study maps dynamic gene expression in mouse mammary glands, revealing insights into lactation, maternal health, and breast cancer risk through imprinting.

18 Sep 2025

Gene-Edited Mosquitoes Block Malaria Transmission

Genetic modification of mosquitoes with the FREP1Q224 allele shows significant promise for malaria elimination, maintaining fitness and reducing infections.

31 Jul 2025

dpMIG-seq Enables Efficient Genetic Analysis of Tetraploid Blueberry

Polyploid crops, such as blueberries, often exhibit complex inheritance patterns that complicate genetic analysis and hinder breeding efforts.

29 Jul 2025

Gene Editing Offers New Hope to Stop Malaria Transmission

Mosquitoes kill more people each year than any other animal. In 2023, the blood-sucking insects infected a reported 263 million people with malaria, leading to nearly 600,000 deaths, 80% of which were children.

24 Jul 2025

Paternal miRNAs Play Unexpected Role in Seed Viability and Embryogenesis

By using targeted gene silencing in different pollen cell types, the study reveals that disrupting DCL1 function either in the vegetative cell or in sperm cells leads to defective seed formation.

14 Jul 2025

Do Genetic Variants That Affect DNA Methylation Influence Colorectal Cancer Risk or Outcomes?

The study identifies genetic variants influencing colorectal cancer risk through DNA methylation, suggesting new avenues for targeted screening and prevention.

20 Jun 2025

Study Identifies Key Yield Traits in Complex Banana Genome

Banana breeding is notoriously difficult. Most cultivated bananas are sterile triploids with limited recombination and long growth cycles.

11 Jun 2025

A New Strategy for High-Fidelity CRISPR Editing in Tomatoes

Gene targeting (GT) via homologous recombination (HR) is a powerful tool for precise genome editing, but its application in plants is limited due to the dominance of canonical non-homologous end-joining (cNHEJ) in double-strand break (DSB) repair.

10 Jun 2025

Mapping the Genetic Blueprint of Flowering Chinese Cabbage

Flowering Chinese cabbage (Brassica rapa ssp. chinensis var. parachinensis), known for its tender stalks and vibrant greens, has long been a dietary mainstay in southern China and beyond.

9 Jun 2025

Meta-Analysis Identifies Genome-Level Associations of FOXP4 Gene With Long COVID

New genome-wide meta-analysis shows FOXP4 gene variants elevate the risk of long COVID (PASC), linking genetic predisposition to persistent symptoms and lung dysfunction. Findings support tailored treatment approaches.

30 May 2025

Mapping DNA's Hidden Switches: A Methylation Atlas

A new study, led by PhD student Jonathan Rosenski under the guidance of Prof. Tommy Kaplan from the School of Computer Science and Engineering and Prof. Yuval Dor from the Faculty of Medicine at the Hebrew University of Jerusalem and Hadassah Medical Center, has been published in Nature Communications, presenting the first comprehensive atlas of allele-specific DNA methylation across 39 primary human cell types.

7 Mar 2025

RNA Splicing Errors May Hold the Key to Beating Gliomas Using Immunotherapy

Identifying splicing-related neoantigens in gliomas opens new avenues for immunotherapy, enhancing treatment strategies for this challenging brain tumor.

26 Feb 2025

CRISPR Unlocks ‘Sleeping’ Genes—A Potential Cure for Prader-Willi Syndrome?

CRISPR epigenome editing successfully reactivates silenced genes in Prader-Willi Syndrome, highlighting potential for targeted therapies in genetic disorders.

20 Feb 2025

Using CRISPR-Cas9 Gene Editing for Chromosomal Rescue in Down Syndrome

Gene editing techniques may eventually allow trisomy to be treated at the cellular level, according to an in vitro proof-of-concept study.

19 Feb 2025

Mismatch Repair Genes Found to be Key Drivers of Huntington's Disease

A new UCLA Health study has discovered in mouse models that genes associated with repairing mismatched DNA are critical in eliciting damages to neurons that are most vulnerable in Huntington's disease and triggering downstream pathologies and motor impairment, shedding light on disease mechanisms and potential new ways to develop therapies.

12 Feb 2025