Alzheimer's Disease News and Research

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Alzheimer's disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks of daily living. In most people with AD, symptoms first appear after age 60. AD is the most common cause of dementia among older people, but it is not a normal part of aging. Dementia refers to a decline in cognitive function that interferes with daily life and activities. AD starts in a region of the brain that affects recent memory, then gradually spreads to other parts of the brain. Although treatment can slow the progression of AD and help manage its symptoms in some people, currently there is no cure for this devastating disease.

Scientists Identify Microglia Immune State Changes for Novel Alzheimer’s Therapies

Researchers from VIB, KU Leuven, the UK-DRI and Muna Therapeutics, funded by, among others, ERC, have uncovered a critical biological transition that may determine whether Alzheimer's disease pathology leads to dementia.

5 Jun 2026

Researchers Link Brain Extracellular Matrix Deterioration to Postmenopausal Memory Loss

A largely overlooked space between cells in women's brains may hold the key to understanding memory loss tied to estrogen decline after menopause, reports a new preclinical Northwestern Medicine study.

26 May 2026

Genetically Engineered Gene Deletions Reveal Unexpected Links Between Ghrelin and Blood Glucose Stability

Hormones influence how we feel - happy, sad or hungry - and profoundly shape how our bodies function and respond to disease.

25 May 2026

Analysis Reveals Blurred Neural Patterns During Failed Cognitive Switches

Most people have experienced the feeling: switching from one task to another, only to find the brain momentarily stuck in the old mode of thinking. Sometimes, even after realizing a strategy no longer works, the mind keeps returning to it anyway.

21 May 2026

Web-Based Platform Facilitates Chemical Structure Queries in Metabolomics

An international team led by researchers at University of California San Diego and University of California, Riverside has developed a free, web‑based platform designed to make public metabolomics data more accessible.

15 May 2026

"Zombie" Macrophages Accumulate in Aging Tissues and Diseased Livers

UCLA researchers have identified a rogue population of immune cells that quietly accumulates in aging tissues and in the livers of people with fatty liver disease. Clearing these cells, they found, dramatically reduced inflammation and reversed liver damage in mice - even while the animals remained on an unhealthy diet.

16 Apr 2026

Janelia Scientists Develop New Method To Study Blood-Brain Barrier Proteins

Think it was hard to get into Studio 54? Try getting through the blood-brain barrier.

10 Apr 2026

RNA Barcoding Technique Reveals Neural Connections at Synapse Level

By tagging neurons with molecular "barcodes," researchers mapped connections among thousands of neurons in the mouse brain with unprecedented speed and resolution.

8 Apr 2026

Mirror Protein Design Blocks Amyloid Beta in Alzheimer’s Disease

Understanding how proteins interact with their own mirror images enabled a Kobe University research team to design a small mirror protein that disables a causal factor of Alzheimer's disease, amyloid-beta.

1 Apr 2026

New PanNDA Atlas Maps Protein Networks in Neurodegenerative Diseases

Neurodegenerative diseases form a tangled biological web with overlapping molecular signatures and symptoms. To decode this complexity, a multi-institute collaboration led by St. Jude Children's Research Hospital scientists developed the pan-neurodegeneration atlas (PanNDA).

24 Mar 2026

Specialized Tanycyte Brain Cells Found to Play Key Role in Tau Clearance

Accumulation of the protein tau in the brain is one of the hallmarks of Alzheimer's disease. In a paper publishing March 5 in the Cell Press journal Cell Press Blue, researchers report a previously unknown mechanism that appears to enable the build-up of tau.

6 Mar 2026

DNA Changes in Alzheimer’s That May Drive Disease Progression

In a study published in Nature Communications, Mayo Clinic researchers discovered particular DNA-level abnormalities in the brains of Alzheimer's patients.

4 Mar 2026

Scientists Map Millions of Oligodendrocytes Across Mouse Brains

Johns Hopkins scientists say they have used 3D imaging, special microscopes and artificial intelligence (AI) programs to construct new maps of mouse brains showing a precise location of more than 10 million cells called oligodendrocytes.

24 Feb 2026

Human 3D Model Shows How the Gut Drives Neurodegeneration

Research on a 3D microfluidic model highlights gut-brain interactions, offering new insights into inflammatory processes linked to neurodegenerative diseases.

18 Feb 2026

Hidden Neuronal Lattice May Shield the Brain From Alzheimer’s

Brain cells are constantly swallowing material from the fluid that surrounds them - signaling molecules, nutrients, even pieces of their own surfaces - in a process known as endocytosis that is essential for learning, memory and basic neural upkeep.

12 Feb 2026

Reprogrammed Engrams Reverse Cognitive Decline in Mice

Age-related memory decline and neurodegenerative diseases like Alzheimer's are often thought of as irreversible.

11 Feb 2026

How a Single List Is Changing Visibility for Women in Science

Cristina Legido-Quigley shares insights on lipidomics and Alzheimer's disease, focusing on metabolic factors and the importance of women's visibility in STEM.

11 Feb 2026

Microglia Found to Drive New Neuron Growth in Adult Hippocampus

Breakthrough research from the University of Cincinnati College of Medicine is revealing how immune cells in the adult brain can regulate the generation of new neurons.

10 Feb 2026

ER-Phagy: A Novel Target for Age-Related Diseases

Improvements in public health have allowed humankind to survive to older ages than ever before, but, for many people, these added golden years are not spent in good health.

4 Feb 2026