Many people start to feel pain and stiffness in their bodies over time. Sometimes their hands or knees or shoulders get sore and are hard to move and may become swollen. These people may have arthritis. Arthritis may be caused by inflammation of the tissue lining the joints. Some signs of inflammation include redness, heat, pain, and swelling. These problems are telling you that something is wrong. Joints are places where two bones meet, such as your elbow or knee. Over time, in some types of arthritis but not in all, the joints involved can become severely damaged. There are different types of arthritis. In some diseases in which arthritis occurs, other organs, such as your eyes, your chest, or your skin, can also be affected. Some people may worry that arthritis means they won’t be able to work or take care of their children and their family. Others think that you just have to accept things like arthritis.
According to recent studies, immune cell DNA mutations that eliminate the immune system's natural brakes may be the cause of autoimmune disorders.
A team of scientists at The University of Texas Medical Branch (UTMB), led by Nikos Vasilakis, PhD, and Peter McCaffrey, MD, has developed a new computational pipeline that could dramatically accelerate the development of vaccines against a group of mosquito-borne viruses known as alphavirus.
Scripps Research scientists have developed a new class of drug compounds that reduce harmful inflammation while leaving the body's ability to fight infections intact-a long-sought goal in treating autoimmune diseases.
A study shows that psoriasis-like immune responses may limit skin cancer growth, challenging the view of chronic inflammation as solely tumor-promoting.
Photoreceptors are specialized cells in the eye that convert light energy into neural signals.
During pregnancy, maternal and fetal cells migrate back and forth across the placenta, with fetal cells entering the mother's bloodstream and tissues.
Human gene maps contain major blind spots because they were built largely from the DNA sequences of people with European ancestry, according to a study published today in Nature Communications.
Researchers at Academia Sinica have developed the first population-specific polygenic risk score (PRS) models for people of Han Chinese ancestry, achieving unprecedented accuracy in predicting risks for common diseases such as diabetes, heart disease, autoimmune disorders.
The immune system faces a delicate balancing act: it must be aggressive enough to fight infections and cancer, yet restrained enough to avoid attacking the body's own tissues.
If cancer is a disease of overabundance, where cells divide without restraint and tumors grow despite the body's best interests, then degenerative diseases are disorders of deprivation.
Drugs to treat inflammatory and autoimmune diseases - such as asthma, psoriasis, rheumatoid arthritis or Chrousos syndrome - act mainly through the glucocorticoid receptor (GR).
Researchers at VIB and Ghent University have uncovered a key mechanism that protects the skin from harmful inflammation.
Egg whites may be perfect for a health-conscious breakfast, but egg yolks turned out to be the key ingredient for cultivating bird embryonic stem cells (ESCs) in the lab.
When environmental stress harms DNA, it can set off a cascade of failures linked to heart conditions, neurodegeneration, and chronic inflammation.
The atomic structures of ADAM17 and iRhom2, revealed by UC researchers, offer new avenues for developing precise treatments for chronic inflammatory conditions.
Conventional transcriptomic techniques have revealed much about gene expression at the population and single-cell level—but they overlook one crucial factor: spatial context.
After spending years tracing the origin and migration pattern of an unusual type of immune cell in mice, researchers have shown in a new study how activity of "good" microbes in the gut is linked to rheumatoid arthritis and, potentially, other autoimmune diseases.
Researchers have uncovered multiple new genes and genetic pathways that could lead to repurposing hundreds of existing drugs for osteoarthritis, the most common form of arthritis.
COVID-19 infection has been associated with an increased risk of autoimmune disorders, such as rheumatoid arthritis and type 1 diabetes.
An international team of researchers led by the University of California San Diego has developed a new strategy to enhance pharmaceutical production in Chinese hamster ovary (CHO) cells, which are commonly used to manufacture protein-based drugs for treating cancer, autoimmune diseases and much more.
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