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Protein ‘Neighborhood’ Holds an ABC Transporter in Place to Regulate Cyclic AMP Signaling

When a cell receives a message from outside, it generates a molecule called cyclic AMP (cAMP) to relay this message. To ensure the signal reaches the correct effector without triggering pathways accidentally, cAMP levels must be maintained around their point of origin and at the right level.

8 Dec 2025

Spatial Touchstone Project Brings Standardization to Spatial Transcriptomics

Spatial transcriptomics provides a unique perspective on the genes that cells express and where those cells are located.

8 Dec 2025

Senescent Fibroblasts in the Tumor Niche Rewire Lung Cancer Metabolism and Plasticity

Senescent fibroblasts are aging cells that no longer divide and protect against tumor development. Yet two decades have gone by since cell biologist Judith Campisi, PhD, paradoxically demonstrated that these same cells can promote cancer growth in a laboratory setting.

5 Dec 2025

New Tool Predicts Which Intrinsically Disordered Regions Drive Condensate Formation

Fusion oncoproteins arise when a gene fuses with another gene and acquires new abilities. Such abilities can include the formation of biomolecular condensates, "droplets" of concentrated proteins, DNA or RNA.

4 Dec 2025

Decoding the Interaction Between SV2A Protein and Anti-Epileptic Drugs

A multi-institute team led by St. Jude Children's Research Hospital and UT Southwestern Medical Center investigators established for the first time how certain drugs used to treat epilepsy affect their target.

2 Dec 2025

Researchers Develop High-Throughput Technique to Decode T-Cell Receptors

Studying T cells, the immune cells most responsible for responding to infections and cancers, just received a significant boost in the form of a new technique from St. Jude Children's Research Hospital.

25 Nov 2025

Discovery Connects Dopamine Receptor Desensitization to Everyday Motivational Fatigue

Our brain's reward system processes and reinforces pleasurable experiences, motivating us to seek out and engage in rewarding activities ranging from eating to social interactions to recreational drug use.

21 Nov 2025

Genetic Insights Reveal Key Drivers of Bone Density in Children

Researchers at Children's Hospital of Philadelphia (CHOP) revealed important genetic components that affect bone density in children and adolescents.

20 Nov 2025

Understanding Genetic Diversity Through Short Tandem Repeats

Scientists at The Hospital for Sick Children (SickKids) have revealed a previously overlooked layer of genetic variation that could help explain why people experience disease differently, and why some treatments work better for certain populations.

17 Nov 2025

AlphaSync Brings Continuous Updates to Global Protein Structure Predictions

The shape, or structure, of proteins determines how they work, making it essential for researchers to have access to high-quality structural models.

12 Nov 2025

CellWhisperer Enables Natural Language Exploration of Single-Cell Biology

Using sophisticated RNA sequencing technology, biomedical researchers can measure the activity of our genes across millions of single cells, creating detailed maps of tissues, organs, and diseases.

12 Nov 2025

Researchers Find "Hidden" Mutations by Tracing Protein Isoforms

Approximately 25 million individuals in the United States are affected by a rare genetic disorder, and a significant number of them face challenges not only due to the absence of effective treatments but also because of insufficient information regarding their condition.

10 Nov 2025

St. Jude Scientists Discover Hidden Binding Pocket in Nuclear Receptors

A study from St. Jude Children's Research Hospital uncovered an alternative binding pocket within nuclear receptors, revealing a much-needed new therapy route for this important class of drug targets.

7 Nov 2025

Comprehensive Kinase Atlas Redefines Regulation of Gene Transcription Machinery

The enzyme RNA polymerase II transcribes genes into messenger RNA. This process is guided by modifications to the enzyme's "tail" called phosphorylation patterns.

7 Nov 2025

New Genomic Method Unlocks Diagnoses for Rare Conditions

A new genomic method has enabled multiple people with rare conditions to receive diagnoses that were previously unattainable by identifying complex structural genetic changes that are often missed by standard tests.

4 Nov 2025

Reactivating a Naturally Occurring Gene Promotes Heart Repair and Regeneration

A naturally occurring gene called Cyclin A2 (CCNA2), which turns off after birth in humans, can actually make new, functioning heart cells and help the heart repair itself from injury including a heart attack or heart failure when the gene is turned back on.

4 Nov 2025