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New Roadmap Fixes Cellular Waste Accumulation to Halt Brain Degeneration

Researchers at University of California San Diego and their colleagues have identified a key cellular pathway that drives brain degeneration in both a rare childhood disorder and the far more common Alzheimer's disease.

13 Aug 2026

Batista Lab Identifies Crucial Protein Targets to Extend Malaria Vaccine Efficacy

A study reveals how targeting specific protein regions in malaria vaccines could enhance efficacy, potentially saving more lives in vulnerable populations.

11 Aug 2026

New Single-Cell Database Reveals Hidden Inner Workings of Spinal Cord Circuits

Scientists at St. Jude Children's Research Hospital created a single-cell atlas of a key class of spinal neurons involved in motor coordination. From that resource, they identified a small subgroup of interneurons associated with the speed of rhythmic movements such as walking. The findings, which have implications for understanding spinal cord function and recovery from injury, were published today in Nature Communications.

11 Aug 2026

Bone Marrow T Cells Exhibit Conditional Preparedness Against Cancer

A team led by researchers from the German Cancer Research Center (DKFZ), the HI-STEM Stem Cell Institute, and Medical Clinic V at Heidelberg University Hospital (UKHD) has characterized T cells in the bone marrow in cases of multiple myeloma and acute myeloid leukemia: A specific group of tumor-reactive T cells can recognize and, in principle, fight cancer cells, but is often not sufficiently activated.

10 Aug 2026

Shuttling Gene Activating Proteins Through Packed Histones Treats Neurodegenerative Disease

Cells can switch off genes by tightly packaging DNA around proteins called histones.

6 Aug 2026

Mapping Spatial Genome Architecture Unlocks Hidden Biological Mechanisms Behind Genetic Risk

Much of how genetic risk leads to disease has remained hidden. In many cases, genetic variants linked to disease do not act on nearby genes along the chromosome. Instead, they influence genes located far away along the DNA sequence.

5 Aug 2026

New Base Editing Strategy Rewrites Genetic Code to Minimize Huntington's Symptoms

A gene editing tool designed to precisely rewrite the gene that causes Huntington's disease reduced toxic protein fragments and symptoms associated with the disease in mice, researchers at the University of Illinois Urbana-Champaign report.

30 Jul 2026

Novel Dendritic Cell Vaccine Redirects Viral Memory to Fight Tumors

In a discovery that could redefine the future of cancer immunotherapy, scientists from Celloram Inc., University Hospitals and Case Western Reserve University have developed a novel cancer vaccine platform that transforms the impact of the largest immunological event in modern history

28 Jul 2026

Study Uncovers Two Distinct Embryonic Macrophage Populations with Different Repair Abilities

In leukemia's most aggressive forms, the blood cell factories in our bone marrow falter. Instead of dividing and multiplying at their usual prolific pace, generating hundreds of billions of new cells daily, some precursor cells stall out at an immature stage.

27 Jul 2026

Researchers Find New Bacterial Mechanism for Evading Antibiotic Exposure

Antibiotics are a medical marvel, but many microbes are gaining the ability to resist and tolerate these therapeutics.

24 Jul 2026

Chemotherapy Leaves Distinct DNA Changes in Childhood Tumors

Nearly half of childhood tumors treated with common types of chemotherapy showed detectable DNA changes linked to treatment within 18 months, according to a new international study led by The Hospital for Sick Children (SickKids).

24 Jul 2026

Changes in RNA Regulation Enable Bacteria to Enter Antibiotic Tolerance

Antibiotics are a medical marvel, but many microbes are gaining the ability to resist and tolerate these therapeutics. St. Jude Children's Research Hospital scientists have uncovered how S. pneumoniae adapts to antibiotic exposure and immune pressures.

23 Jul 2026

Hidden Cellular Sub Compartments Drive Final Steps of Ribosome Assembly

The nucleolus is a liquid-like cellular organelle where protein factories called ribosomes are assembled.

20 Jul 2026

New Double Donut Structure Reveals How SPOP Protein Regulates Cancer

Mutations to the protein SPOP are widespread in cancer, yet many remain poorly understood. To address this gap, St. Jude Children's Research Hospital scientists obtained structures of SPOP in both the presence and absence of these mutations.

14 Jul 2026

Prolonged C1 Neuron Activation Causes Heightened Long-Term Panic Behaviors

Anxiety disorders affect more than 300 million people globally. Several brain regions have been linked to anxiety, but how these regions connect has been poorly understood.

11 Jul 2026

Antibody-Based Strategy Makes Stem Cell Transplants Safer

Stem cell transplantation (also called bone marrow transplantation) and gene therapy are among the most powerful curative approaches for blood diseases such as sickle cell disease, b-thalassemia, immune deficiencies, and some blood cancers.

9 Jul 2026

Using Bacteriophages to Treat Inflammatory Bowel Disease

A research team at McMaster University has developed a targeted approach to treating inflammatory bowel disease (IBD) using bacteriophages, viruses that infect specific bacteria, to disarm harmful microbes without disrupting the broader gut ecosystem.

9 Jul 2026

Gut Bacteria Actively Manage Vitamin A Delivery for T Cell Maturation

Scientists at UT Southwestern Medical Center have discovered that gut bacteria help regulate the development of the body's immune system by directing the movement of vitamin A through a previously unrecognized cellular network.

8 Jul 2026

Scientists Identify Biological Link Between Low Birth Weight and Chronic Disease

Researchers have long sought to discover why babies who weigh less than expected at birth, a condition known as small for gestational age, or SGA, are at higher risk for heart, lung and metabolic diseases as adults.

3 Jul 2026

High Stomach Regeneration Rates Can Trigger Tumor Development

Few areas of the body face more daily stress and potential damage than the stomach, which must manage everything we swallow. Along with this constant strain, the stomach also produces acid that can damage its own lining and increase the risk of ulcers.

1 Jul 2026