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Research Pinpoints HMGN1 as Cause of Trisomy 21-Related Heart Abnormalities

Three copies of chromosome 21 causes Down syndrome (DS), and roughly half of children born each year in the United States with DS-approximately 2,600-also have congenital heart defects (CHDs).

23 Oct 2025

Salton Sea Dust Causes Immediate Changes to Lung Microbes and Immune Response

Not only does dust from the drying Salton Sea in California smell awful. Researchers at UC Riverside discovered that inhaling the dust might rapidly alter the microscopic environment within the lungs.

23 Oct 2025

Disarming Cancer’s Droplet Hubs to Halt Tumor Growth

In a city, coworking hubs bring people and ideas together. Inside cancer cells, similar hubs form-but instead of fueling progress, they supercharge disease. That's what researchers at the Texas A&M University Health Science Center (Texas A&M Health) have discovered inside the cells of a rare and aggressive kidney cancer.

21 Oct 2025

Longevity Gene from Centenarians Reverses Heart Damage in Rare Genetic Disorder

A new breakthrough in a rare genetic disease which causes children to age rapidly has been discovered using 'longevity genes' found in people who live exceptionally long lives - over 100 years old.

16 Oct 2025

Combating Influenza A Virus with CRISPR and Human Lung Organ Chips

The Influenza A virus (IAV) has been the cause of six major flu pandemics, responsible for 50 to 100 million deaths globally.

16 Oct 2025

Biological Effects of Childhood Abuse Uncovered Through Epigenome-Wide Analysis

Child maltreatment, which includes abuse and neglect, is one of the most serious public health concerns worldwide.

16 Oct 2025

Structural Insights into Heat Shock Chaperone Complex and Protein Handoffs

The first full-length structures of two heat shock chaperone proteins in a complex reveal the key structural region regulating their function, according to a new study from St. Jude Children's Research Hospital.

15 Oct 2025

Discovery Reveals How Microbes Evolve Rapidly Inside the Human Gut

Everywhere you go, you carry a population of microbes in your gastrointestinal tract that outnumber the human cells making up your body.

14 Oct 2025

St. Jude Researchers Uncover Dual Role of ASPL in Stress Granule Assembly and Disassembly

Stress granules are droplet-like protein hubs that temporarily shield fragile RNA from cellular stresses such as toxins. VCP is a protein essential for breaking up stress granules and has been linked to neurodegenerative diseases.

10 Oct 2025

Acidic Tumor Environment Found to Rewire Cancer Cell Metabolism

Tumors are not a comfortable place to live: oxygen deficiency, nutrient scarcity, and the accumulation of sometimes harmful metabolic products constantly stress cancer cells.

10 Oct 2025

New Genetic Insights Offer Hope for Early Detection of Osteosarcoma

Researchers at Cleveland Clinic Children's have helped identify a previously unknown gene that increases the risk of developing osteosarcoma, the most common type of malignant bone tumor in children and young adults.

10 Oct 2025

Multiple Genetic Changes Play Key Role in the Development of Complex Disorders

The genetic roots of a disease or disorder do not always grow into clear cut, easily diagnosed clinical features.

8 Oct 2025

Scientists Derive Authentic Embryonic Stem Cells From Chickens and Other Birds

Egg whites may be perfect for a health-conscious breakfast, but egg yolks turned out to be the key ingredient for cultivating bird embryonic stem cells (ESCs) in the lab.

30 Sep 2025

Study Reveals How Lymphatic Cells Preserve Immune Memory

A study published today in Nature Communications describes how lymphatic endothelial cells assist in generating robust immune memory, offering new insights into how the immune system functions.

26 Sep 2025

Protein Networks Expose New Therapeutic Targets for Alzheimer's

A recent study conducted by the Icahn School of Medicine at Mount Sinai provides one of the most thorough insights to date regarding the interactions of brain cells in Alzheimer’s disease, illustrating protein networks that expose communication breakdowns and highlight potential new therapeutic avenues for treatment.

26 Sep 2025