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Scientists Discover Unique Chromosome Reorganization in Developing Germ Cells

Researchers at the MRC Laboratory of Medical Sciences (LMS) and Imperial College London have shown for the first time that, before they can start developing into egg and sperm cells, the embryonic precursors of these cells uniquely reshape the 3D organization of their genetic material.

23 Feb 2026

SeekGene Joins Human Cell Atlas Consortium to Advance Multiomics Research

SeekGene, a biotechnology company focused on "driving the development and democratization of innovative single-cell technologies", announced it has officially joined the Human Cell Atlas (HCA) Commercial Discount Program, providing eligible consortium members with exclusive commercial discounts on its single-cell platforms and assays to support large-scale cell atlas research worldwide.

12 Feb 2026

Bone-building hormone eases chronic low back pain by restoring vertebral microarchitecture

Parathyroid hormone shows promise in treating low back pain by remodeling degenerating vertebral endplates and limiting pathological sensory innervation.

12 Feb 2026

Autism-Linked Mutations Converge on Shared Early Brain Pathways

UCLA Health researchers have created a comprehensive map showing how eight different genetic mutations associated with autism spectrum disorder affect early brain development, providing new insights into the ways diverse genetic causes may lead to shared features and symptoms of the disorder.

29 Jan 2026

Rice Researchers Create Accurate 3D Structures of Chromosomes Using FI-Chrom Method

Chromosomes are masters of organization. These long strings of DNA fold down into an ensemble of compact structures that keep needed parts of the genome accessible while tucking away those that aren't used as often.

28 Jan 2026

Novel Epigenetic Regulator Enhances Downy Mildew Resistance in Brassica rapa

Downy mildew is a major constraint on Brassica crop production worldwide, especially during early developmental stages when plants are highly vulnerable to infection.

27 Jan 2026

Parallel Molecular Routes Ensure Accurate Centromere Specification During Cell Division

Despite the immense amount of genetic material present in each cell, around three billion base pairs in humans, this material needs to be accurately divided in two and allocated in equal quantities.

9 Jan 2026

Dual Genetic Mutations Drive RNA Mis-Splicing and Leukemia Progression

Treating acute myeloid leukemia (AML) depends on knowing what goes wrong inside cells. A new study suggests that two genetic mutations – IDH2 and SRSF2 – work cooperatively to mis-splice RNA messages and change how blood cells develop.

6 Jan 2026

LINE-1 Retrotransposons Reshape Cancer Genome Architecture

Scientists at St. Jude Children's Research Hospital have revealed previously unappreciated roles for the retrotransposon LINE-1 in shaping the cancer genome structure and regulation.

6 Jan 2026

Mapping the Four Dimensional Organization of the Human Genome

A new study challenges what's long been assumed about genetic variants thought to always cause inherited blindness.

23 Dec 2025

CRISPR Reveals Dark Genome Regions That Sense Cellular Mechanics

Researchers at Duke University used CRISPR technologies to discover previously unannotated stretches of DNA in the 'dark genome' that are responsible for controlling how cells sense and respond to the mechanical properties of their local environment.

12 Dec 2025

Scientists Discover First Human DNA-Cutting Enzyme That Responds to Tension

An international research team at the University of Hong Kong has discovered a human protein known as ANKLE1, which is recognized as the first DNA-cutting enzyme (nuclease) in mammals that can detect and respond to physical tension in DNA.

10 Dec 2025

Researchers Capture the Most Detailed Images of Molecules in Chromatin Condensates

A team of researchers led by HHMI Investigator Michael Rosen has captured the most detailed images yet of the molecules in chromatin condensates — droplet-like structures of compacted DNA.

5 Dec 2025

PLAMseq Revolutionizes Simultaneous Analysis of Genome Proteins and Their Locations

A team from the Andalusian Centre for Molecular Biology and Regenerative Medicine (CABIMER) has developed an innovative technique called PLAMseq (proximity-labelled affinity-purified mass spectrometry plus sequencing) that, for the first time, allows simultaneous analysis of chromatin-associated proteins and their location in the genome in a single experiment.

5 Dec 2025

Scientists Map How Transcription Factors Interpret DNA Sequences

With a new study in the journal Cell, researchers at Stanford University and Stockholm University have contributed to increased knowledge about gene regulation in human cells.

27 Nov 2025

DNA Rigidity Inside the Nucleosome Regulates INO80 Positioning

Researchers at The University of Texas MD Anderson Cancer Center have shown that DNA inflexibility, or rigidity, inside the nucleosome regulates the positioning of INO80. This highlights that the physical structure and shape of DNA, not just genetic information, are key components of DNA transcription.

26 Nov 2025

Targeting Rhoa to Restore Function in Hematopoietic Stem Cells

Aging is defined as the deterioration of function overtime, and it is one of the main risk factors for numerous chronic diseases.

25 Nov 2025

Novel Mechanism for Epigenetic Patterning in Plants

Every cell within an organism shares an identical genetic blueprint. Their distinct identities stem from epigenetics—precise chemical markers that dictate gene expression.

24 Nov 2025

Discovery Reveals Greater Epigenetic Complexity in Unicellular Life

Multicellular organisms (animals, plants, human) all have the ability to methylate the cytosine © base in their DNA. This process, a type of epigenetic modification, plays an important role in conditions such as cancer and processes such as aging.

19 Nov 2025

RNA Molecules Alter Genome Structure to Silence Critical Neuronal Genes During Stress

What if the brain's response to stress could be read not in fleeting neurotransmitter bursts, but in the quieting of genes deep inside chromatin? Researchers at the University of Alabama at Birmingham have now shown that stress hormones may silence crucial neuronal genes through an unexpected class of RNA molecules that operate not by encoding proteins, but by reshaping the genome's architecture.

5 Nov 2025