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New Tool Studies Kinase Activity During DNA Damage

Cornell researchers have developed a powerful new biosensor that reveals, in unprecedented detail, how and where kinases – enzymes that control nearly all cellular processes – turn on and off inside living cells.

14 Nov 2025

New "Ultra-Mild" Method Corrects Cancer DNA Methylation Test Errors

Traditional bisulfite sequencing damages DNA, while enzyme-based alternatives are inconsistent. A novel methylation analysis method, called UMBS-seq, was published this week in Nature Communications. UMBS-seq achieves both accuracy and gentleness, unlocking more reliable cancer biomarker detection.

13 Nov 2025

Global Constraint Principle Offers Fresh Insight into Life’s Growth Limits

A research team including a scientist of Earth-Life Science Institute (ELSI) at Institute of Science Tokyo, Japan, has identified a novel principle in biology that mathematically explains why the growth of organisms slows as nutrients become more abundant-a phenomenon known as "the law of diminishing returns."

12 Nov 2025

Scientists Build a Genetic Map to Predict Bacterial Resistance Mechanisms

The bacteria Acinetobacter baumannii (A. baumannii) is a haunting presence in many hospitals in the United States, where more than one in 100 patients are treated for A. baumannii infections.

10 Nov 2025

Comprehensive Kinase Atlas Redefines Regulation of Gene Transcription Machinery

The enzyme RNA polymerase II transcribes genes into messenger RNA. This process is guided by modifications to the enzyme's "tail" called phosphorylation patterns.

7 Nov 2025

Scientists Reveal Nonenzymatic Role of NUDT5 in Purine Pathway Regulation

Inside every cell, a finely tuned metabolic network determines when to build, recycle, or stop producing essential molecules.

7 Nov 2025

Hidden Role of Biliverdin Reductase A in Fighting Oxidative Damage

According to a new study from Johns Hopkins Medicine, the enzyme biliverdin reductase A (BVRA) protects neurons directly from oxidative stress, regardless of whether it produces the yellow pigment bilirubin.

5 Nov 2025

Enzyme BVRA Found to Shield Neurons from Oxidative Stress

New research from Johns Hopkins Medicine shows that the enzyme biliverdin reductase A (BVRA) plays a direct protective role against oxidative stress in neurons, independent of its role producing the yellow pigment bilirubin.

4 Nov 2025

Synthetic Nanocompartments Offer a New Route to Boost Photosynthesis in Crops

Australian researchers have created tiny compartments to help supercharge photosynthesis, potentially boosting wheat and rice yields while slashing water and nitrogen use.

31 Oct 2025

Protein Dysfunction Could be the Cause of Diseases Resulting From Shortened Telomeres

New research from the University of Wisconsin–Madison reveals that dysfunction in a protein essential to maintaining stability in our chromosomes may be responsible for serious - and sometimes deadly - diseases.

31 Oct 2025

Unexpected Enzyme Strategy Behind Antibiotic Resistance

Researchers at McGill University have identified two enzymes that employ an unprecedented mechanism to provide resistance, thereby introducing a new dimension in the fight against antimicrobial resistance (AMR), which ranks among the top 10 global public health challenges.

31 Oct 2025

How Gut Bacteria Influence Mammalian Cell Physiology

The microbiome-the trillions of bacteria, viruses, and fungi that live quietly in our body-plays a crucial role in shaping human health by providing a variety of micronutrients necessary for vital functions.

30 Oct 2025

Hidden RNA Inside a Gene Solves Decades-Old Telomere Mystery in Roundworms

An international research team led by Hiroki Shibuya at RIKEN Center for Biosystems Dynamics Research (BDR) in Japan has solved a genetic mystery and revealed a previously unknown way that DNA can control what cells do.

24 Oct 2025

Study Shows Flatulence Gas Hydrogen is Crucial for Gut Health

Farts are causing a stink in the research world, but in a positive way.

24 Oct 2025

DNA Cassettes Enable Long-Lasting Antibody Production Directly Inside Patients

A multidisciplinary team of scientists led by The Wistar Institute, including Perelman School of Medicine at the University of Pennsylvania, AstraZeneca and Inovio Pharmaceuticals, published today in Nature Medicine a breakthrough in biologic antibody production that happens directly in human subjects in this encouraging first clinical trial of its kind.

23 Oct 2025

Serotonin-Producing Gut Microbes May Hold the Key to Treating IBS

Research from the University of Gothenburg, Sweden, clarifies the complex interaction between gut bacteria and IBS.

21 Oct 2025

New AI Model Unlocks the Therapeutic Potential of Lasso Peptides

In the hunt for new therapeutics for cancer and infectious diseases, lasso peptides prove to be a catch.

17 Oct 2025

PapB Could Make Ozempic-Style Drugs Stronger and Last Longer

Chemistry researchers at the University of Utah have discovered an enzyme referred to as PapB, which is capable of "tying off" therapeutic peptides, drugs resembling proteins, into compact rings, a process termed macrocyclization.

17 Oct 2025

KCTD10 Acts as a Traffic Controller to Prevent DNA Damage in Dividing Cells

Mayo Clinic researchers have identified a protein that acts like a traffic controller for DNA, preventing damage during cell division - a discovery that could lead to new cancer therapies, according to a study published in Nature.

14 Oct 2025

Smart Proteins Bring Precision Drug Delivery Closer to Reality

Targeted drug delivery is a powerful and promising area of medicine. Therapies that pinpoint the exact areas of the body where they're needed - and nowhere they're not - can reduce the medicine dosage and avoid potentially harmful "off target" effects elsewhere in the body.

10 Oct 2025