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Yeast-Based Platform Achieves Animal-Free High Quality Chondroitin Sulfate

By systematically redesigning multiple metabolic modules inside Komagataella phaffii, the researchers achieved both high product yield and high sulfation quality, two goals that have long been difficult to reach at the same time.

21 Jan 2026

Engineered Human Skin Acts as a Living Biosensor for Inflammation

Implanted living skin-based biosensors offer a breakthrough in inflammation tracking, providing real-time biomarker monitoring without invasive procedures.

21 Jan 2026

Mapping the Human E3 Ligase Landscape

Maintaining cellular order is a major logistical challenge: Individual mammalian cells contain billions of protein molecules, which must be synthesized, deployed, and removed with precision.

19 Jan 2026

Backyard Soil Bacterium Produces Antibiotic Built to Outsmart Resistance

Early in 2025, scientists discovered a promising new antibiotic in a soil sample from a lab technician's backyard.

16 Jan 2026

Fly Pigmentation Study Uncovers Genes Influencing Dopamine, Sleep, and Movement

Dopamine in the brain influences movement, learning, motivation and sleep. In humans, problems with dopamine are linked to conditions like Parkinson's disease, depression and sleep disorders.

14 Jan 2026

New Enzyme and Bacteria Unlock Efficient Production of Healthy Sweetener

From saccharin in the 19th century to stevia and monk fruit in the 21st, researchers and the food industry have long sought a sweetener that delivers the taste of sugar without its drawbacks-excess calories, tooth decay, and heightened risk for obesity, insulin resistance, and diabetes.

14 Jan 2026

Deep Learning–Based Codon Optimization Framework Boosts Protein Expression in E. coli

By combining Transformer-based sequence modeling with a novel conditional probability strategy, the approach overcomes long-standing trade-offs between maximizing expression metrics and maintaining translational features critical for proper protein folding.

9 Jan 2026

New Molecules Harness Cellular Recycling to Eliminate Cancer's Immune Shield IDO1

Cells have a remarkable housekeeping system: proteins that are no longer needed, defective, or potentially harmful are labeled with a molecular "tag" and dismantled in the cellular recycling machinery.

8 Jan 2026

Synthetic Biology and Metabolic Engineering Drive Microbial L-Tryptophan Biomanufacturing

This review synthesizes progress in pathway optimization, regulatory rewiring, and microbial cell factory design that has driven L-Trp titers to industrially relevant levels while enabling the biosynthesis of downstream products ranging from neurotransmitters and plant hormones to dyes and complex alkaloids.

8 Jan 2026

Blocking Retinoic Acid Pathway Improves Dendritic Cell Anti-Tumor Function

Scientists at the Princeton University Branch of the Ludwig Institute for Cancer Research have identified novel mechanisms by which a metabolic derivative of vitamin A-all-trans retinoic acid-compromises both the body's normal anti-cancer immune response and, in a different context, the efficacy of a promising type of cancer vaccine.

6 Jan 2026

New CHANGE-seq-BE Method Sharpens Safety Assessment of CRISPR Base Editors

Scientists and physicians can better assess precision genome editing technology using a new method made public today by St. Jude Children's Research Hospital.

5 Jan 2026

Fungal Detoxification Pathway Enables Infestation of Bark Beetle Pests

Spruce bark is rich in phenolic compounds that protect trees from pathogenic fungi. A research team at the Max Planck Institute for Chemical Ecology in Jena investigated how these plant defenses function within the food web, particularly in spruce bark beetles (Ips typographus), which ingest the compounds through their diet. Could the beetles use substances from the spruce's defenses to protect themselves against pathogenic fungi?

30 Dec 2025

Researchers Find Enzyme That Controls Fat Production, Offering New Drug Target

Obesity is a global epidemic and a major cause of morbidity and mortality because it increases the risk for comorbidities, including heart disease and fatty liver disease (MASLD). Rates of these disorders have risen as the world increasingly adopts energy-dense diets and sedentary lifestyles.

24 Dec 2025

Cell Wall Stiffness Directs Plant Stem Cell Fate

Imagine if our bodies could grow new organs throughout our entire lives. Plants do this constantly, thanks to the tiny, powerful reservoirs of stem cells. But how do these cells know when to divide, and how do they ensure each division is perfectly oriented to build a leaf, a stem, or a flower?

18 Dec 2025

RNAConnect Launches the UltraMarathonRT Direct RNA‑Seq Kit to Advance Nanopore-Based Native RNA Sequencing

RNAConnect, a life science company providing next generation tools to the RNA community, today announced the commercial availability of the UltraMarathonRT® Direct RNA‑Seq (uMRT DRS) Kit, a native‑RNA library preparation solution for Oxford Nanopore Technologies® direct RNA sequencing (SQK-RNA004).

From RNAConnect 17 Dec 2025

Scientists Discover First Human DNA-Cutting Enzyme That Responds to Tension

An international research team at the University of Hong Kong has discovered a human protein known as ANKLE1, which is recognized as the first DNA-cutting enzyme (nuclease) in mammals that can detect and respond to physical tension in DNA.

10 Dec 2025

How Tumor Stem Cells Hijack Neutrophils to Evade Immunotherapy

Immunotherapy has revolutionized cancer care by training the immune system to detect and destroy tumors.

9 Dec 2025

PLAMseq Revolutionizes Simultaneous Analysis of Genome Proteins and Their Locations

A team from the Andalusian Centre for Molecular Biology and Regenerative Medicine (CABIMER) has developed an innovative technique called PLAMseq (proximity-labelled affinity-purified mass spectrometry plus sequencing) that, for the first time, allows simultaneous analysis of chromatin-associated proteins and their location in the genome in a single experiment.

5 Dec 2025

Study Uncovers Principles Guiding Replication Initiation Across the Human Genome

When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process can cause alterations in genomic DNA, promoting cellular aging, cancer, and genetic disorders.

4 Dec 2025

Ambiguous Stop Codons Expand the Genetic Code in Archaea

The beauty of the DNA code is that organisms interpret it unambiguously. Each three-letter nucleotide sequence, or codon, in a gene codes for a unique amino acid that's added to a chain of amino acids to make a protein.

2 Dec 2025