Fibroblast News and Research

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Fibroblasts are connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.

Biofabrication Study Explores How Immune Cells Aid Tumor Survival

A new "tumor-on-a-chip" model is giving scientists a live look at how pancreatic cancer can recruit the body's own immune cells to help tumors survive.

9 Jul 2026

New Research Identifies Molecular Switch for Disfiguring Hypertrophic Skin Scars

A research team has uncovered a cellular and molecular mechanism that may help explain why some wounds develop into hypertrophic scars, the raised and often rigid scars that can cause itching, pain, disfigurement, and restricted movement.

26 Jun 2026

Targeting Fibroblast Communication Could Halt Primary Sjögren Disease Damage

In autoimmune disorders, immune cells targeting 'self' proteins are mistakenly activated, resulting in their abnormal expansion and responsiveness. It has been known to reduce the quality of life of patients over a prolonged period.

25 Jun 2026

Peking University Researchers Map High Dimensional Cellular Networks in Tumors

A comprehensive review led by Associate Researcher Linnan Zhu and Academician Zemin Zhang at Biomedical Pioneering Innovation Center (BIOPIC), Peking University, China, and Chongqing Medical University, China, was published in Volume 2, article number 27 of the journal Immunity & Inflammation on June 05, 2026.

13 Jun 2026

Bispecific Antibodies Target Tumors While Sparing Healthy Tissue

A new generation of bispecific antibodies effectively targets cancer cells, minimizing toxicity and enhancing treatment precision in preclinical studies.

3 Jun 2026

Restricted Interaction Peptides Change Shape to Lock Therapy Inside Solid Tumors

Medications are designed to treat diseased tissues while sparing healthy ones, often by attaching the drug to something that helps guide it directly to its target.

14 May 2026

Stage-Dependent Gene Expression Changes Reveal Cellular Aging Dynamics

A new research paper was published in Volume 18 of Aging-US on April 10, 2026, titled "Stage-dependent transcriptomic changes in human dermal fibroblast senescence model."

30 Apr 2026

Engineered Human Skin Acts as a Living Biosensor for Inflammation

Implanted living skin-based biosensors offer a breakthrough in inflammation tracking, providing real-time biomarker monitoring without invasive procedures.

21 Jan 2026

Human-Derived 3D Skin Model May Replace Animals In Wound Studies

Engineered 3D skin model successfully simulates early wound healing, offering insights into inflammatory responses and potential therapeutic applications.

3 Sep 2025

Tumors Use Mitochondrial Transfer to Reprogram Surrounding Cells

Tumors have developed many strategies and tricks to gain advantages in the body. Led by cell biology professor Sabine Werner, researchers at ETH Zurich have now discovered another surprising trick that certain tumors resort to in ensuring their survival and growth.

1 Sep 2025

Muscle Reprogramming Protein Found to Both Activate and Repress Genes

For more than 30 years, scientists have studied how the myogenic determination gene number 1 (MYOD) protein binds DNA to modify the gene expression of muscle stem cells.

11 Aug 2025

Parkinson’s Gene Mutation Blocks Vital Neuroprotective Signals

GBA1 mutations impair ciliary Hedgehog signaling in Parkinson's disease, reducing neuroprotective factors and highlighting a shared pathogenic pathway.

7 Aug 2025

New Study Reveals Varied CAR T-Cell Therapy Benefits in Large B-Cell Lymphoma

A study identifies three patient subgroups in large B-cell lymphoma, revealing distinct responses to CD19 CAR T cell therapy and enhancing precision medicine.

20 Jun 2025

Integrating Imaging and Molecular Profiling to Transform Treatment of Intrahepatic Cholangiocarcinoma

ICCA accounts for 10–15% of primary liver cancers and is notorious for late-stage diagnosis and resistance to chemotherapy and radiotherapy.

13 Jun 2025

Johns Hopkins Team Identifies Distinct Subtypes of Senescent Skin Cells

Senescent skin cells, often referred to as zombie cells because they have outlived their usefulness without ever quite dying, have existed in the human body as a seeming paradox, causing inflammation and promoting diseases while also helping the immune system to heal wounds.

29 Apr 2025

Unraveling the Role of Long Noncoding RNAs in the Tumor Microenvironment

The tumor microenvironment (TME) is a complex and dynamic network consisting of tumor cells, immune cells, stromal cells, extracellular matrix (ECM), cytokines, and growth factors, all interacting to influence tumorigenesis, progression, and metastasis.

25 Apr 2025

The Future of Chicken? Scientists Grow Whole Cuts in a Bioreactor

This research introduces a hollow fiber bioreactor for cultured chicken meat, optimizing tissue engineering with enhanced perfusion and structural integrity.

25 Apr 2025

Colossal Creates the Colossal Woolly Mouse, Showcasing Breakthroughs in Multiplex Genome Editing and Trait Engineering on the Path to a Mammoth

In an extraordinary achievement of advanced multiplexed genome engineering, Colossal Biosciences announces the birth of the Colossal Woolly Mouse—mice engineered to express multiple key mammoth-like traits that provide adaptations to life in cold climates.

5 Mar 2025

Study Uncovers Immune Cell Interaction Driving Aggressive Brain Tumor Growth

A type of aggressive, treatment-resistant brain tumor has a distinct population of immune cells that support its growth, according to new research led by investigators at the Johns Hopkins Kimmel Cancer Center Bloomberg~Kimmel Institute for Cancer Immunotherapy and the Johns Hopkins University School of Medicine.

11 Feb 2025

New CRISPR Tool Reveals Key Lymphoma Genes

This study presents an optimized CRISPR-Cas12a system for large-scale genetic screening, revealing critical genes involved in lymphoma development and therapy.

7 Feb 2025