Fibroblast News and Research

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Fibroblasts are connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.

Dendritic Cell STING Activation Licenses Cytotoxic T Lymphocyte Priming

Immune checkpoint inhibitors (ICIs) have transformed cancer care, yet only a subset of patients benefit. A major barrier is tumor microenvironment (TME) heterogeneity: "hot" tumors are enriched with cytotoxic T lymphocytes (CTLs) and respond better, while "cold" tumors lack T-cell infiltration or are shielded by immunosuppressive barriers.

20 Oct 2026

In Vitro Herd Immunity Threshold Experimentally Demonstrated Without Uniform Mixing Assumptions

A research team led by Professor Sungsu Park of the School of Mechanical Engineering and Professor Byung Mook Weon of the School of Advanced Materials Science and Engineering at Sungkyunkwan University (SKKU) has developed a compact, centimeter-scale microfluidic "Herd-Immunity-on-a-Chip" platform that recreates key features of viral transmission in human societies within a controllable laboratory system.

8 Oct 2026

Spatial Single-Cell Transcriptomics Maps Cellular Niches in Fatal COVID-19 Lungs

Researchers at the University of Liège have used imaging-based spatial single-cell transcriptomics to map the cellular organization of lungs from people who died with severe COVID-19.

5 Oct 2026

Multi-Receptor Blocking Achieves Superior Antifibrotic Response Over Single-Receptor Inhibition

Three adenosine receptor subtypes that normally send different signals were found to converge on a common pathway that activates cardiac fibroblasts, the scar-forming cells in the heart. Blocking the receptors together produced a much stronger antifibrotic effect than blocking them one at a time.

25 Sep 2026

Cancer-Associated Fibroblasts Construct Physical Barriers Limiting Antitumor T Cell Infiltration

Researchers at The University of Texas MD Anderson Cancer Center have identified a previously unknown pathway that prostate tumors leverage to suppress the immune system by reshaping the tumor microenvironment to resist treatment.

25 Sep 2026

UCLA Team Develops Advanced Immunotherapy to Fight Dangerous Arterial Plaques

A UCLA research team has engineered a new type of immune cell that attacks atherosclerotic plaques — the fatty buildup inside artery walls that drives most heart attacks and strokes.

23 Sep 2026

Advanced RNA Sequencing Separates Rare Regenerative Cells From Mature Tissue

Researchers at Weill Cornell Medicine and Hospital for Special Surgery have discovered the unspecialized stem cells that give rise to the body's tendons and ligaments, the tissues connecting muscles and bones.

8 Sep 2026

Many Misfolded Proteins Manage to Evade the Cellular Maintenance Crew

As proteins are made in a cell, they are folded into the 3-D structure that allows them to work, but sometimes this process can go wrong.

4 Sep 2026

Biofabrication Study Explores How Immune Cells Aid Tumor Survival

A new "tumor-on-a-chip" model is giving scientists a live look at how pancreatic cancer can recruit the body's own immune cells to help tumors survive.

9 Jul 2026

New Research Identifies Molecular Switch for Disfiguring Hypertrophic Skin Scars

A research team has uncovered a cellular and molecular mechanism that may help explain why some wounds develop into hypertrophic scars, the raised and often rigid scars that can cause itching, pain, disfigurement, and restricted movement.

26 Jun 2026

Targeting Fibroblast Communication Could Halt Primary Sjögren Disease Damage

In autoimmune disorders, immune cells targeting 'self' proteins are mistakenly activated, resulting in their abnormal expansion and responsiveness. It has been known to reduce the quality of life of patients over a prolonged period.

25 Jun 2026

Peking University Researchers Map High Dimensional Cellular Networks in Tumors

A comprehensive review led by Associate Researcher Linnan Zhu and Academician Zemin Zhang at Biomedical Pioneering Innovation Center (BIOPIC), Peking University, China, and Chongqing Medical University, China, was published in Volume 2, article number 27 of the journal Immunity & Inflammation on June 05, 2026.

13 Jun 2026

Bispecific Antibodies Target Tumors While Sparing Healthy Tissue

A new generation of bispecific antibodies effectively targets cancer cells, minimizing toxicity and enhancing treatment precision in preclinical studies.

3 Jun 2026

Restricted Interaction Peptides Change Shape to Lock Therapy Inside Solid Tumors

Medications are designed to treat diseased tissues while sparing healthy ones, often by attaching the drug to something that helps guide it directly to its target.

14 May 2026

Stage-Dependent Gene Expression Changes Reveal Cellular Aging Dynamics

A new research paper was published in Volume 18 of Aging-US on April 10, 2026, titled "Stage-dependent transcriptomic changes in human dermal fibroblast senescence model."

30 Apr 2026

Engineered Human Skin Acts as a Living Biosensor for Inflammation

Implanted living skin-based biosensors offer a breakthrough in inflammation tracking, providing real-time biomarker monitoring without invasive procedures.

21 Jan 2026

Human-Derived 3D Skin Model May Replace Animals In Wound Studies

Engineered 3D skin model successfully simulates early wound healing, offering insights into inflammatory responses and potential therapeutic applications.

3 Sep 2025

Tumors Use Mitochondrial Transfer to Reprogram Surrounding Cells

Tumors have developed many strategies and tricks to gain advantages in the body. Led by cell biology professor Sabine Werner, researchers at ETH Zurich have now discovered another surprising trick that certain tumors resort to in ensuring their survival and growth.

1 Sep 2025

Muscle Reprogramming Protein Found to Both Activate and Repress Genes

For more than 30 years, scientists have studied how the myogenic determination gene number 1 (MYOD) protein binds DNA to modify the gene expression of muscle stem cells.

11 Aug 2025

Parkinson’s Gene Mutation Blocks Vital Neuroprotective Signals

GBA1 mutations impair ciliary Hedgehog signaling in Parkinson's disease, reducing neuroprotective factors and highlighting a shared pathogenic pathway.

7 Aug 2025