Genome Editing News and Research

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CRISPRi Screening Reveals Genetic Insights into Cyanobacteria Acclimation

Cyanobacteria are the most abundant photosynthetic microorganisms on Earth. They live in nearly every habitat throughout the world, from permafrost to hot springs and from soils to oceans.

5 Sep 2025

DNA-Wrapped Nanoparticles Enhance Efficiency of Gene Editing Tools

With the power to rewrite the genetic code underlying countless diseases, CRISPR holds immense promise to revolutionize medicine.

2 Sep 2025

AI-Powered Gene Editing Method Enables Unprecedented Precision

A research team headed by the University of Zurich has developed a powerful new method to precisely edit DNA by combining cutting-edge genetic engineering with artificial intelligence.

13 Aug 2025

Researchers Uncover How Macrophages Respond to Infection Stress

Fighting infections requires speed and accuracy. A team of researchers from CeMM and MedUni Vienna, led by Christoph Bock and Matthias Farlik, explored how macrophages—the body’s initial responders—handle this stress.

11 Aug 2025

New PCE Systems Enable Precise Genome Engineering Across Kilobase to Megabase Scales

A team of Chinese researchers led by Prof. GAO Caixia from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences has developed two new genome editing technologies, known collectively as Programmable Chromosome Engineering (PCE) systems.

5 Aug 2025

Gene Editing Reverses Symptoms of Rare Brain Disorder in Mice

Scientists have corrected gene mutations in mice causing an ultra-rare disease by editing DNA directly in the brain with a single injection, a feat with profound implications for patients with neurological diseases.

22 Jul 2025

Paternal miRNAs Play Unexpected Role in Seed Viability and Embryogenesis

By using targeted gene silencing in different pollen cell types, the study reveals that disrupting DCL1 function either in the vegetative cell or in sperm cells leads to defective seed formation.

14 Jul 2025

New Software Boosts Genome Editing Accuracy for Genetic Therapies

This innovative software, CRISPRware, optimizes guide RNA design for genome editing, supporting research on genetic disorders and uncharacterized peptides.

9 Jul 2025

Iowa State Engineers Reinvent Gene Gun for Faster and Safer Crop Editing

Plant scientists have used a standard "gene gun" since 1988 to genetically modify crops for better yield, nutrition, pest resistance and other valuable traits.

5 Jul 2025

A New Strategy for High-Fidelity CRISPR Editing in Tomatoes

Gene targeting (GT) via homologous recombination (HR) is a powerful tool for precise genome editing, but its application in plants is limited due to the dominance of canonical non-homologous end-joining (cNHEJ) in double-strand break (DSB) repair.

10 Jun 2025

Repairing DNA Double-Strand Breaks May Improve Genomic Stability by Limiting Organelle-to-Nucleus Gene Transfer

A new study in Nature Plants reveals that DNA double-strand break repair (DSBR) pathways help prevent gene transfer from organelles to the nucleus in plants. Disruption of DSBR increases the risk of genomic instability through endosymbiotic gene transfer (EGT).

2 Jun 2025

Epigenome Editing: Enhancing Endonuclease Protein Design for In Vivo Applications

Researchers have engineered a compact, high-specificity IscB variant, NovaIscB, for safe, persistent in vivo epigenome editing using AAV delivery, offering a powerful tool for gene regulation without DNA breaks.

28 May 2025

Novel Bacterial Immune Weapon that Starves Viral Invaders

The discovery of Cat1 reveals how CARF effectors use complex structures to inhibit viral replication, advancing our understanding of bacterial immune responses.

19 May 2025

Scientists Unlock Microbial Stress Responses with Advanced Gene Silencing

Scientists at Oak Ridge National Laboratory and the University of Colorado Boulder used a gene-silencing tool and a large library of molecular guides to understand how photosynthetic bacteria adapt to light and temperature changes.

10 May 2025

New Gene Editing Tool Alters Mitochondrial Mutation Levels in Stem Cells

Mitochondrial diseases affect approximately 1 in 5,000 people worldwide, causing debilitating symptoms ranging from muscle weakness to stroke-like episodes.

5 May 2025

AI-Powered Protein Engineering for Precise and Scalable Gene Therapy

Genome editing has progressed rapidly, showing promising outcomes for the treatment of genetic disorders, yet there remains potential for enhancement.

23 Apr 2025

Breakthrough Delivery System Advances CRISPR-Based Treatments

A research team from Helmholtz Munich and the Technical University of Munich has developed an advanced delivery system that transports gene-editing tools based on the CRISPR/Cas9 gene-editing system into living cells with significantly greater efficiency than before.

10 Apr 2025

Wheat's Pathogen Defense Strengthened by Tandem Kinase Proteins

Wheat is grown over more land area than any other food crop. Among pathogen-driven threats to wheat, fungi top the list, causing billions of dollars of losses each year and posing a serious challenge to food security worldwide.

3 Apr 2025

Plants Repurpose Gas Exchange Genes for Improved Defense Against Herbivores

Throughout evolution, plants have continuously adapted to survive in changing environments. Apart from complex structural changes, plants have also developed various defense strategies against herbivores, including tougher protective layers, thorns, and chemical deterrents.

29 Mar 2025

Breakthrough Gene Therapy Shows Promise for Treating Hereditary Hearing Loss

Congenital hearing loss refers to impaired auditory function that occurs due to genetic causes. GJB2 is the gene responsible for approximately half of all cases of hereditary hearing loss.

28 Mar 2025