Immune System News and Research

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New Multi-Target CAR-T Cells Eradicate Glioblastoma in Preclinical Models

With a five-year survival rate of less than 5%, glioblastoma is one of the most aggressive types of brain cancer.

21 Nov 2025

New Cloaked CRISPR Technology Reveals Hidden Gene Targets for Cancer Metastasis

The immune system plays a crucial role in fighting tumors and metastases. Consequently, it is decisive to conduct cancer research in mouse models with an immune system that is as natural as possible – which is easier said than done.

21 Nov 2025

LEVA Enables Real-Time Tracking of Extracellular Vesicle Communication

In stunning new time-lapse videos, biological nanoparticles scoot and flit across a starry field of glowing dots.

19 Nov 2025

Sabotaging T Cell Exhaustion for Cancer Therapy

Like all hardworking things, the cytotoxic T lymphocytes (CTLs) of the immune system charged with detecting and destroying cancer cells tend to get very tired-so much so, in fact, that they can even die from exhaustion.

18 Nov 2025

Blocking a Hidden Tumor Pathway Revives the Immune System

A new study has discovered a molecular signal that tumors exploit to exhaust the T cells meant to destroy them-and how silencing that signal could revive the body's immunity.

18 Nov 2025

FOXP3 Gene Regulation Holds Key to Immune Therapies

The immune system faces a delicate balancing act: it must be aggressive enough to fight infections and cancer, yet restrained enough to avoid attacking the body's own tissues.

14 Nov 2025

Brain Immune Cells Found to Act as Accelerators and Brakes for Anxiety

Anxiety disorders are some of the most common mental health conditions in America, affecting about one in five people nationwide.

12 Nov 2025

Deciphering PARP14's Role in Viral Pathogenesis

Researchers at the University of Kansas have identified that the human gene encoding the protein PARP14 plays a crucial role in regulating interferon, a key component of the body’s innate immune system.

12 Nov 2025

Enhancing Ovarian Cancer Treatment with Multi-Modal Immunotherapy Approach

Results of a study led by researchers at Roswell Park Comprehensive Cancer Center show that combining two types of immunotherapy - engineered T cells that secrete bispecific T cell engagers (BiTEs) and an immune checkpoint inhibitor - can alter the tumor microenvironment to launch a stronger attack against ovarian cancer and reduce the risk of relapse.

27 Oct 2025

Mitochondria and Lysosomes Orchestrate Metabolic States of Regulatory T Cells

Metabolism guides the activation states of regulatory T cells, the immune cells that prevent inappropriate activation of the immune system.

27 Oct 2025

Disrupted Circadian Rhythms Alter Gene Activity in Alzheimer’s Disease

Alzheimer's disease is notorious for scrambling patients' daily rhythms. Restless nights with little sleep and increased napping during the day are early indicators of disease onset, while sundowning, or confusion later in the day, is typical for later stages of the disease.

24 Oct 2025

Scientists Reveal How Nanovaccines Boost the Immune Fight Against Aggressive Breast Cancers

Nanovaccines show promise in breast cancer therapy, enhancing immune activation and targeting cold tumors, particularly in challenging triple-negative cases.

24 Oct 2025

DNA Cassettes Enable Long-Lasting Antibody Production Directly Inside Patients

A multidisciplinary team of scientists led by The Wistar Institute, including Perelman School of Medicine at the University of Pennsylvania, AstraZeneca and Inovio Pharmaceuticals, published today in Nature Medicine a breakthrough in biologic antibody production that happens directly in human subjects in this encouraging first clinical trial of its kind.

23 Oct 2025