Immune System News and Research

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Researchers Uncover Protective Role of Mucosal IgA Against Colorectal Cancer

Antibodies that coat the lining of your gut may be playing an important role in preventing colon cancer from developing, Rockefeller University scientists have discovered.

13 Nov 2026

What Monkeys Can Teach Us About the Origins of Disgust

Research reveals how early experiences and disease exposure shape pathogen avoidance behavior in macaques, offering insights into evolutionary immunity.

11 Nov 2026

Exploring Nervous System Interactions to Uncover Novel Ovarian Cancer Therapies

One of the biggest breakthroughs in modern cancer treatment doesn't attack cancer directly.

10 Nov 2026

Multi Immersion Microscope Captures Rapid 3D Dynamics in Living Cells

An international team of researchers led by UT Southwestern Medical Center has developed a versatile light-sheet microscope that captures 3D views of biological samples, from activity inside living cells to larger tissues.

6 Nov 2026

Novel Molecular Bridge Links Coagulation Cascade with Cancer Hormonal Environment

New Cleveland Clinic research published in Cancer Cell shows that people with glioblastoma have more active platelets, which are cells involved in blood clotting. Platelets also communicate with other cells and can influence immune activity.

4 Nov 2026

Innate Immune Sensor cGAS Acts as Nuclear Metabolic Regulator

Scientists at the University of North Carolina Lineberger Comprehensive Cancer Center have discovered an unexpected role for a key innate immune protein, revealing how it helps regulate cholesterol levels inside cells and influences tumor growth and treatment response.

4 Nov 2026

CRISPR Screen Uncovers COMPASS Pathway Role in Suppressing Gut Autoimmunity

3 Nov 2026

Mitochondrial Iron Accumulation Drives Perforin Mediated Cancer Cell Death

For decades, scientists have known that a protein made by T cells and natural killer (NK) cells in the immune system, called perforin, can kill tumor cells by punching a hole in the cell wall and injecting proteases called granzymes, which kill the cell.

2 Nov 2026

New Computational Tool Resolves Evolutionary Paradox of Genome Expansion

A genome contains all of the DNA of every living organism, but its contents don't stop there – most of these structures also contain snippets of DNA that can copy and paste themselves to "infect" a genome, expanding its size. Precisely why that happens remains a mystery.

2 Nov 2026

Aberrant RNA Splicing Generates Immunogenic Neoantigens in Systemic Lupus

Scientists at La Jolla Institute for Immunology (LJI) and the University of Washington (UW) have discovered that patients with lupus have unusual mutations that may turn their bodies into battlegrounds.

30 Oct 2026

St. Jude Scientists Discover Gene-Regulatory Pathway Protecting Gut Immune Balance

Trillions of bacteria live in the human gut without triggering an immune response. Scientists at St. Jude Children's Research Hospital have now discovered a gene-regulatory pathway that helps maintain this delicate balance. Published today in Science Advances, they showed that a type of immune cell, regulatory T cells, co-opt a well-known general gene expression pathway called COMPASS to suppress inappropriate immune responses and prevent lethal inflammation and autoimmunity.

30 Oct 2026

Lung Scarring Claims 11 Australian Lives Every Day: Landmark Report

A respiratory condition that leaves the lungs irreversibly scarred is claiming almost 4,000 Australian lives every year, with an alarming number of cases caused by workplace exposures in industries such as mining, farming and construction.

28 Oct 2026

Taurine Deficiency Triggers Innate Immune Sensing of Cellular Danger Signals

Sustained low-level inflammation is a hallmark of the aging process. The accumulating damage persistently activates the innate immune system-the body's first line of defense-leading to what is known as inflammaging, functional decline and chronic diseases of old age.

26 Oct 2026

Squeezing Cell Nuclei Loosens DNA to Boost CRISPR Reprogramming Efficiency

Our cells hold about two meters of DNA, folded and compacted to fit inside a nucleus far narrower than a strand of human hair.

24 Oct 2026

Evaxion Announces 89% Vaccine Target Precision and Sustained T-Cell and Clinical Responses at Three-Year Follow-Up in Phase 2 Trial with Personalized Cancer Vaccine EVX-01

Evaxion A/S, a clinical-stage TechBio company developing novel immunotherapies with its pioneering AI-Immunology™ platform, announces new three-year immune and clinical outcome data for personalized cancer vaccine EVX-01 in patients with advanced melanoma.

From Evaxion A/S 24 Oct 2026

Carrier-Free Jet Vaccine Method Protects Against COVID-19 and Flu in Animal Studies

A needle-free vaccination method protected mice against the viruses that cause COVID-19 and flu, offering a possible new way to deliver mRNA vaccines while limiting unwanted inflammation.

24 Oct 2026

Metabolic Reprogramming Enhances Gamma Delta CAR T Solid Tumor Clearance

By turning a patient's own immune cells into stronger cancer-fighting cells, CAR T-cell therapy has transformed how some blood cancers are treated. But it's been harder to extend this approach to solid tumors, including cancer that has spread to the bone.

21 Oct 2026

Balancing Immune Cells May Unlock Hidden Human Regenerative Potential

In a study of fingertip regeneration, a team led by JAX Senior Research Scientist James Godwin found that some immune cells in mice can attack and kill cells needed to rebuild bone, while a subset of those same immune cells can protect the bone-making cells and allow regeneration to continue.

16 Oct 2026

Novel Molecular Pathway Identified to Combat T-Cell Exhaustion in Cancer

Researchers at the UCLA Health Jonsson Comprehensive Cancer Center used a CRISPR screen to identify a key molecular pathway that drives exhaustion in cancer-fighting immune cells, limiting their ability to keep tumors under control.

16 Oct 2026

Naturally Occurring Protein Balances Immune Protection and Excessive Tissue Inflammation

A naturally occurring protein can help the immune system fight viral infections while also reducing the damaging inflammation that often accompanies them, a new study from McMaster University has found.

16 Oct 2026