Immune System News and Research

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Enhancing Ovarian Cancer Treatment with Multi-Modal Immunotherapy Approach

Results of a study led by researchers at Roswell Park Comprehensive Cancer Center show that combining two types of immunotherapy - engineered T cells that secrete bispecific T cell engagers (BiTEs) and an immune checkpoint inhibitor - can alter the tumor microenvironment to launch a stronger attack against ovarian cancer and reduce the risk of relapse.

27 Oct 2025

Mitochondria and Lysosomes Orchestrate Metabolic States of Regulatory T Cells

Metabolism guides the activation states of regulatory T cells, the immune cells that prevent inappropriate activation of the immune system.

27 Oct 2025

Disrupted Circadian Rhythms Alter Gene Activity in Alzheimer’s Disease

Alzheimer's disease is notorious for scrambling patients' daily rhythms. Restless nights with little sleep and increased napping during the day are early indicators of disease onset, while sundowning, or confusion later in the day, is typical for later stages of the disease.

24 Oct 2025

Scientists Reveal How Nanovaccines Boost the Immune Fight Against Aggressive Breast Cancers

Nanovaccines show promise in breast cancer therapy, enhancing immune activation and targeting cold tumors, particularly in challenging triple-negative cases.

24 Oct 2025

DNA Cassettes Enable Long-Lasting Antibody Production Directly Inside Patients

A multidisciplinary team of scientists led by The Wistar Institute, including Perelman School of Medicine at the University of Pennsylvania, AstraZeneca and Inovio Pharmaceuticals, published today in Nature Medicine a breakthrough in biologic antibody production that happens directly in human subjects in this encouraging first clinical trial of its kind.

23 Oct 2025

Cracking the Code of T Cell Expansion Inside Tumors

The ability of immune cells-particularly CD8+ T cells-to launch a rapid burst of proliferation inside tumors is key to the success of modern day cancer immunotherapies.

22 Oct 2025

Autophagy Protein ATG9A Shields the Skin from Harmful Inflammation

Researchers at VIB and Ghent University have uncovered a key mechanism that protects the skin from harmful inflammation.

21 Oct 2025

Breakthrough in Lab-Grown Blood Stem Cells Using Self-Organizing Embryo Models

University of Cambridge scientists have used human stem cells to create three-dimensional embryo-like structures that replicate certain aspects of very early human development - including the production of blood stem cells.

14 Oct 2025

Discovery Reveals How Microbes Evolve Rapidly Inside the Human Gut

Everywhere you go, you carry a population of microbes in your gastrointestinal tract that outnumber the human cells making up your body.

14 Oct 2025

GlyTR Therapeutics Unveils Groundbreaking Glycan-Targeting Cancer Immunotherapy

GlyTR Therapeutics, a biotech company pioneering development of glycan-targeting cancer immunotherapies, announced the publication of its foundational technology in the journal, Cell.

14 Oct 2025

RfaH Identified as Key to Bacterial Survival in Hostile Environments

Researchers at Umeå University have identified a key molecular player that helps bacteria survive the hostile environment inside the body.

10 Oct 2025

Antibody 04_A06 Neutralizes Nearly All Tested HIV Variants in Laboratory Studies

A Cologne-led research team has discovered the antibody 04_A06, which neutralizes the human immunodeficiency virus (HIV) in almost all tested variants in vitro and even overcomes typical resistance mechanisms.

7 Oct 2025

New Technology can Map RNA-Protein Interactions Inside Human Cells

Bioengineers at the University of California San Diego have developed a powerful new technology that can map the entire network of RNA-protein interactions inside human cells - an achievement that could offer new strategies for treating diseases ranging from cancer to Alzheimer's.

3 Oct 2025