Lung Cancer News and Research

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Lung cancer is the world's most common cancer and kills more people than any other cancer. In 2008, approximately 1.52 million new cases of lung cancer were diagnosed worldwide, with 1.31 million people dying from the disease.(14) In the United States, an estimated 161,840 deaths, accounting for 29 percent of all cancer deaths, occurred in 2008, according to the American Cancer Society (ACS).

Study Identifies SMARCB1 and MEOX2 Genes as Growth Regulators of Lung Cancers

A Cancer Gene Therapy study reveals that MEOX2 promotes lung cancer progression while SMARCB1 acts as a tumor suppressor, influencing EGFR expression and response to tyrosine kinase inhibitors.

30 May 2025

Meta-Analysis Identifies Genome-Level Associations of FOXP4 Gene With Long COVID

New genome-wide meta-analysis shows FOXP4 gene variants elevate the risk of long COVID (PASC), linking genetic predisposition to persistent symptoms and lung dysfunction. Findings support tailored treatment approaches.

30 May 2025

Mutation Profiling Reveals Therapeutic Targets in Lung Squamous Cell Carcinoma

Lung Squamous cell carcinoma (LSCC) represents the second most common non-small cell lung cancer. Although studies identified adenocarcinoma-like driver mutations in LSCC using next-generation sequencing (NGS), the disease is challenging to treat due to the limited number of detectable mutations for targeted drug therapy.

27 May 2025

Tracheal Basal Cells Identified as Origin of Lung Squamous Cell Carcinoma

The 'cell of origin' of the second most common lung cancer and the way that it becomes dominant in the lung have been discovered, in a new study in mice and humans from researchers at UCL, the Wellcome Sanger Institute and the University of Cambridge.

2 May 2025

Unraveling the Role of Long Noncoding RNAs in the Tumor Microenvironment

The tumor microenvironment (TME) is a complex and dynamic network consisting of tumor cells, immune cells, stromal cells, extracellular matrix (ECM), cytokines, and growth factors, all interacting to influence tumorigenesis, progression, and metastasis.

25 Apr 2025

Tumor Recurrence Prediction from Multi-Omics Information by Deep Learning

MULGONET combines deep learning and multi-omics analysis to predict tumor recurrence, addressing interpretability and enhancing cancer prognosis understanding.

16 Apr 2025

Lab-Grown Lung Cancer Cells to Unlock Targeted Treatments

Scientists at the Cancer Research Manchester Institute have created a new model of Lung Squamous Cell Carcinoma (LUSC), a common type of lung cancer, to study the development, activity, and vulnerabilities of the disease.

9 Apr 2025

Horses' Unique Genetic Adaptation for Superior Endurance Revealed

Researchers have revealed a secret behind horses' exceptional endurance – a mutation in the KEAP1 gene that boosts energy production while protecting against cellular oxidative stress.

28 Mar 2025

A Next-Gen CRISPR Tool Just Dropped

Over the past 15 years, developments in the gene-editing technique known as CRISPR-Cas9 have produced significant new understandings of the functions that particular genes play in a variety of disorders.

21 Mar 2025

AI Revolutionizes Cell Analysis for Personalized Cancer Treatment

A groundbreaking artificial intelligence (AI)-driven neural network has been developed to swiftly analyze and interpret millions of cells from patient samples, enabling predictions of molecular alterations within tissues.

19 Mar 2025

Researchers Create 'Colocatome' to Study Tumor Cell Interactions

Even cells experience peer pressure. Scientists have long studied the ins and outs of cancer cells to learn more about the disease, but they're increasingly finding that noncancerous cells near the cancer cells exert a powerful influence over a tumor's trajectory.

13 Mar 2025

New ctDNA Model Enhances Metastatic Cancer Surveillance

In metastatic cancer surveillance, monitoring the actual concentrations of circulating tumor DNA (ctDNA) may be critical. Researchers showed that absolute ctDNA concentration thresholds can be defined to rule out or predict impending cancer progression.

25 Feb 2025

Unlocking Cancer’s Secret Strategy: Tumor Cells Work Together To Survive

Research uncovers tumor cell cooperation via CNDP2, suggesting new therapeutic strategies that disrupt nutrient sharing to inhibit cancer growth effectively.

25 Feb 2025

New Approach to Cancer Treatment Through Nutrient Deprivation

Scientists had previously ignored the cooperative method by which cancer cells obtain nutrients from their surroundings, but it may be a promising target for cancer treatment.

20 Feb 2025

Lung Cancer Cells Develop Electrical Autonomy to Aid Tumor Growth

Researchers from the Francis Crick Institute have found that some particularly aggressive lung cancer cells can develop their own electric network, like that seen in the body's nervous system.

13 Feb 2025

Mitochondrial Transfer Uncovered as Key Player in Cancer Immune Evasion

The immune system plays a key role in detecting and destroying cancer cells. Cancer immunotherapy works by programming immune cells to recognize and eliminate cancer cells.

12 Feb 2025

Revolutionary Model Identifies Tumor-Fighting Immune Cells in Lung Cancer

Researchers at the Johns Hopkins Kimmel Cancer Center and Bloomberg~Kimmel Institute for Cancer Immunotherapy have developed a computer model to help scientists identify tumor-fighting immune cells in patients with lung cancer treated with immune checkpoint inhibitors.

4 Feb 2025

Ribosomal Fingerprints: A Novel Approach to Early Cancer Detection

Different types of cancer have unique molecular 'fingerprints' which are detectable in early stages of the disease and can be picked up with near-perfect accuracy by small, portable scanners in just a few hours, according to a study published today in the journal Molecular Cell.

11 Dec 2024

Brazilian Study Offers Fresh Perspectives on Pancreatic Cancer Genetics

Pancreatic cancer has recently been included in the list of diseases about which Brazil's National Cancer Institute (INCA) periodically publishes statistics.

9 Dec 2024

Discovery of Large Tandem Duplications Opens New Avenues for Cancer Treatment

Cancer researchers at the University of Chicago and the University of California, San Francisco (UCSF) have discovered that mutations in certain genes can lead to the accumulation of DNA errors, resulting in a specific type of genetic change known as large tandem duplications (TDs) that can arise from the collision of two critical cellular processes: transcription and DNA replication.

21 Nov 2024