Schizophrenia News and Research

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Schizophrenia is a chronic debilitating disorder which affects more than two million Americans, and millions more worldwide. While significant progress has been made in understanding the disease and developing treatments, there remains a significant unmet medical need. More than 50% of patients switch their medication in a given year due to either poor response or the experience of adverse events.

Researchers Develop New Technique to Detect Causality in Neural Spike Trains

Understanding the brain's functional architecture is a fundamental challenge in neuroscience. The connections between neurons ultimately dictate how information is processed, transmitted, stored, and retrieved, thus forming the basis of our cognitive functions.

10 Sep 2025

PV Interneurons Regulate Social Behavior and Empathy in Mice

A special set of neurons directs mice's attention to or away from their peers, depending on the situation. The Kobe University discovery has implications for finding causes for neuropsychiatric conditions such as autism spectrum disorder or schizophrenia.

27 Aug 2025

New Research Explains How Alcohol Inhibits Gut Health

Alcohol-associated liver disease (ALD) is a leading cause of liver transplantation and mortality globally, and its effect is only increasing.

27 Aug 2025

Hormone-Sensitive Brain Circuit Drives Mating Behaviors in Mice

In animals with social structures, the drive to reproduce is a complex process; governed by the brain, it's influenced by both internal cues such as hormones and external factors such as interactions with potential mates.

17 Jul 2025

Hippocampal Neurons Show Surprising Flexibility in Brain Signal Processing

The brain is constantly mapping the external world like a GPS, even when we don't know about it. This activity comes in the form of tiny electrical signals sents between neurons -- specialized cells that communicate with one another to help us think, move, remember and feel.

17 Jun 2025

UC Davis Study Links Specific microRNAs to Mental and Neurological Disorders

A study in Nature Aging from researchers at the UC Davis School of Medicine has identified specific microRNAs - non-coding RNAs that regulate gene expression within cells - that likely contribute to bipolar disorder, depression, schizophrenia, post-traumatic stress disorder (PTSD) and Parkinson's disease.

5 Jun 2025

Exon-Specific Analysis Uncovers Novel Insights into Psychiatric Disease

This research highlights the role of exons in mental illnesses, offering new perspectives on genetic factors that influence psychiatric disorder development.

3 Jun 2025

Study Reveals How Genetic Differences in TRIO Affect Neurodevelopment

Researchers have identified how variations in a gene called TRIO can influence brain functions and result in distinct neurodevelopmental diseases.

24 May 2025

Same Gene Mutations Can Require Different Treatments in Autism and Schizophrenia

For patients with disorders such as autism and schizophrenia, mutations in the same gene could require different treatments, according to new research from Yale School of Medicine (YSM).

6 May 2025

New Brain Organoid Model Reveals How Microglia Respond to Viral Infections

Organoids have revolutionized science and medicine, providing platforms for disease modeling, drug testing, and understanding developmental processes.

4 Apr 2025

Study Reveals How Syngap1 Gene Affects Touch-Based Perception in Mice

You may scarcely notice it, but much of what you do every day requires your brain to engage in perceptual learning.

14 Mar 2025

Research Reveals Key Mitochondrial Role in Social Recognition Memory

Virginia Tech neuroscientists have uncovered a mitochondrial process that supports the brain cells critical for learning, memory, and social recognition.

10 Feb 2025

Neuropilin2 Gene Disruption Impacts Brain Circuitry in Autism and Epilepsy

The gene neuropilin2 encodes a receptor involved in cell-cell interactions in the brain and plays a key role in regulating the development of neural circuits.

10 Jan 2025

New Discovery Sheds Light on How Monoamines Regulate Brain Rhythms

A collaborative effort between Mount Sinai and Memorial Sloan Kettering Cancer Center has shed valuable light on how monoamine neurotransmitters such as serotonin, dopamine, and now histamine help regulate brain physiology and behavior through chemical bonding of these monoamines to histone proteins, the core DNA-packaging proteins of our cells.

9 Jan 2025

Study Reveals How Toxoplasma Parasite Evades Drug Treatment by Altering Protein Production

A study by Indiana University School of Medicine researchers sheds new light on how Toxoplasma gondii parasites make the proteins they need to enter a dormant stage that allows them to escape drug treatment.

10 Dec 2024

Dopamine and Serotonin Act as Opposing Forces in Learning and Reward

If you've heard of two of the brain's chemical neurotransmitters, it's probably dopamine and serotonin. Never mind that glutamate and GABA do most of the work -; it's the thrill of dopamine as the "pleasure chemical" and serotonin as tender mood-stabilizer that attract all the headlines.

26 Nov 2024

New Method for Understanding Brain Function and Dysfunction

An international group of researchers from FutureNeuro, the Research Ireland Centre for Translational Brain Science, and RCSI University of Medicine and Health Sciences have created a novel technique to characterize gene activity in the living human brain.

26 Nov 2024

New Study Links Cannabis Use to DNA Methylation Changes in Mental Health Pathways

Research reveals that frequent high-potency cannabis use alters DNA methylation, affecting mitochondrial and immune genes, with implications for mental health.

25 Oct 2024

New Insights Into Early Brain Development and Mental Health

An unparalleled glimpse at how gene regulation changes during human brain development has been provided by a study led by UCLA, which demonstrates the crucial role played by the 3D structure of chromatin, which is made up of proteins and DNA.

10 Oct 2024

New Tool START Enables Precision Mapping of Neuronal Connectivity

Scientists at the Salk Institute are unveiling a new brain-mapping neurotechnology called Single Transcriptome Assisted Rabies Tracing (START). The cutting-edge tool combines two advanced technologies-;monosynaptic rabies virus tracing and single-cell transcriptomics-;to map the brain's intricate neuronal connections with unparalleled precision.

1 Oct 2024