Vaccine News and Research

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A vaccine is a biological preparation that improves immunity to a particular disease. A vaccine typically contains an agent that resembles a disease-causing microorganism, and is often made from weakened or killed forms of the microbe. The agent stimulates the body's immune system to recognize the agent as foreign, destroy it, and "remember" it, so that the immune system can more easily recognize and destroy any of these microorganisms that it later encounters.

Researchers Develop STITCHR to Insert Whole Genes Without Unwanted Mutations

Investigators from Mass General Brigham and Beth Israel Deaconess Medical Center have developed STITCHR, a new gene editing tool that can insert therapeutic genes into specific locations without causing unwanted mutations.

12 Apr 2025

Study Reveals How Cells Process and Degrade mRNA Vaccines

A team of researchers led by Dr. Kim V. Narry, director of the Center for RNA Research at the Institute for Basic Science (IBS), has uncovered a key cellular mechanism that affects the function of mRNA vaccines and therapeutics.

4 Apr 2025

New Brain Organoid Model Reveals How Microglia Respond to Viral Infections

Organoids have revolutionized science and medicine, providing platforms for disease modeling, drug testing, and understanding developmental processes.

4 Apr 2025

Enhanced Oral Vaccination with Competitive Gut Bacteria

Researchers are combining vaccination with targeted colonization of the intestine by innocuous microorganisms to combat bacterial infections. This strategy might signal a sea change in the antibiotic crisis.

4 Apr 2025

4basebio Receives MHRA GMP Licence for Manufacture and Supply of Synthetic DNA

4basebio PLC (“4basebio”), a company which develops and commercializes the large-scale manufacture of synthetic DNA as well as nanoparticle delivery solutions, today announced that it has received Good Manufacturing Practice (GMP) certification from the UK’s Medicines and Healthcare products Regulatory Agency (MHRA).

3 Apr 2025

Scientists Build Live African Swine Fever Virus From Synthetic DNA Using CRISPR

Utilizing CRISPR-Cas9, scientists reconstitute live African swine fever virus from synthetic genomes, accelerating vaccine development for this deadly virus.

2 Apr 2025

Thermo Fisher Scientific and Chan Zuckerberg Institute for Advanced Biological Imaging Collaborate to Further Understanding of Human Cells

Thermo Fisher Scientific Inc., the world leader in serving science, has announced a Technology Alliance Agreement with the Chan Zuckerberg Institute for Advanced Biological Imaging (CZ Imaging Institute).

28 Mar 2025

How B Cells Know When to Mutate—and When to Chill

Study reveals B cells suppress mutations during rapid division, enhancing immune response and offering critical insights for vaccine and treatment development.

27 Mar 2025

Zika and Dengue Virus Use Different Strategies to Infect Dendritic Cells

Zika virus and dengue virus are very close relatives. Both are mosquito-borne flaviviruses, and both specialize in infecting a host's dendritic cells.

26 Mar 2025

Unveiling Bacterial Immune Mechanisms Against Temperate Phages

Like humans, bacteria can be attacked by viruses. In the case of bacteria, these viral attackers are referred to as bacteriophages, a term derived from the Greek word for bacteria-eaters, or simply “phages.”

24 Mar 2025

New Insights into How B Cells Strategically Clone High-Affinity Antibodies

A vaccine's ability to generate long-lasting, high-affinity antibodies hinges on a delicate balance. Upon exposure to a vaccine or pathogen, B cells scramble to refine their defenses, rapidly mutating in hopes of generating the most effective antibodies.

20 Mar 2025

Study Finds Key Mechanism Behind Plasma Cell Migration for Lasting Immunity

Vaccine effectiveness relies on creating a strong antibody response that can be reactivated to fight future infections.

13 Mar 2025

$30 Million Grant Supports AI-Powered Antibody Therapy Development

An ambitious project led by Vanderbilt University Medical Center investigators aims to use artificial intelligence technologies to generate antibody therapies against any antigen target of interest.

10 Mar 2025

Dual Antibodies Found to Combat All SARS-CoV-2 Variants

A Stanford-led team has found two antibodies that can work together to defeat all SARS-CoV-2 variants. More research is needed, but the approach could help in the development of treatments to keep pace with evolving viruses.

6 Mar 2025

Researchers Develop Mycobacteria Strains with Kill Switches for Safer TB Vaccines

Working toward more effective tuberculosis (TB) vaccines, researchers at Weill Cornell Medicine have developed two strains of mycobacteria with "kill switches" that can be triggered to stop the bacteria after they activate an immune response.

26 Feb 2025

T Cells May Hold the Secret to Fighting Dengue Virus

Children who experience multiple cases of dengue virus develop an army of dengue-fighting T cells, according to a new study led by scientists at La Jolla Institute for Immunology (LJI).

25 Feb 2025

New Lipid Nanoparticles Deliver mRNA for Lung Tissue Regeneration

New research from the Perelman School of Medicine at the University of Pennsylvania suggests that a combination of messenger RNA (mRNA) and a novel lipid nanoparticle (LNP) could potentially be used to repair lung damage.

24 Feb 2025

New Method Helps Detect Mutations Causing Immune Escape in Viruses

Viruses are masters at disguise. When they are pushed too far by our immune system, they send new virus variants into play that are no longer recognized by immune cells.

31 Jan 2025

Leveraging AI to Aid the Development of T Cell Vaccine Candidates

An exciting collaboration between the Ragon Institute and the Jameel Clinic at MIT has achieved a significant milestone in leveraging artificial intelligence (AI) to aid the development of T cell vaccine candidates.

29 Jan 2025

New Method Helps T Cells Live Longer and Fight Cancer More Effectively

Researchers from the University of Pittsburgh have developed a new way to grow T cells in the lab that enables them to live longer and better destroy cancer cells in a mouse model of melanoma compared to those grown in traditional growth media.

29 Jan 2025