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Chaperone protein imbalance initiates toxic accumulation of tau in the aging brain

Chaperone protein imbalance can play a significant role in initiating toxic accumulation of tau in the aging brain - an early step in the development of Alzheimer's disease and related neurodegenerative disorders known as tauopathies, a new preclinical study by University of South Florida Health (USF Health) neuroscientists suggests.

21 Apr 2021

Researchers uncover a key genetic culprit in the development of acute lymphoblastic leukemia

Using a widely known field of mathematics designed mainly to study how digital and other forms of information are measured, stored and shared, scientists at Johns Hopkins Medicine and Johns Hopkins Kimmel Cancer Center say they have uncovered a likely key genetic culprit in the development of acute lymphoblastic leukemia (ALL).

21 Apr 2021

Study highlights the importance of autophagy in gene regulation

A fine balance between the production and degradation of biomolecules is required for optimal cell function. Autophagy is a mechanism through which cells break down and recycle their own components.

20 Apr 2021

Key discovery could prevent treatment failure in people with severe hemophilia A

Recently, researchers achieved a crucial discovery that could mitigate and eliminate immune responses causing treatment failure in people with hemophilia A.

20 Apr 2021

Study shows how tau aggregates promote Alzheimer’s disease

If looked deep into the brain of a patient with Alzheimer’s disease or those suffering from the most types of dementia or the concussion-associated syndrome, called chronic traumatic encephalopathy (CTE), there would be hairball-like tangles of a protein known as tau—a common suspected culprit.

20 Apr 2021

Interferon-stimulating genes control SARS-CoV-2 replication

Researchers have found a set of human genes that combat infection due to SARS-CoV-2, the virus responsible for causing COVID-19.

20 Apr 2021

Antibodies may not inhibit SARS-CoV-2 variants from minks

It has been known for about a year that minks can become infected with SARS-CoV-2. The virus had been transmitted from humans to farmed mink and mutated in infected animals. Mutations were acquired in the spike protein, which is crucial for the entry of the virus into host cells and represents the central point of attack for antibodies.

20 Apr 2021

3D biomaterial helps implanted stem cells stick around to reverse arthritis

A 3D biomaterial scaffold design to slowly release stem cells has worked to ensure implanted stem cells stick around to relieve pain and reverse arthritis in mice knee joints.

19 Apr 2021

Supercomputer simulations reveal the behavior of dominant G form SARS-CoV-2 strain

Large-scale supercomputer simulations at the atomic level show that the dominant G form variant of the COVID-19-causing virus is more infectious partly because of its greater ability to readily bind to its target host receptor in the body, compared to other variants.

19 Apr 2021

New breakthrough in understanding the role of high-risk immune genes in rheumatoid arthritis

Researchers within the Biomedicine Discovery Institute at Monash University have made a breakthrough in understanding the role played by high-risk immune genes associated with the development of rheumatoid arthritis (RA).

19 Apr 2021

New CRISPR technology allows scientists to switch off any gene in human cells

Scientists have figured out how to modify CRISPR's basic architecture to extend its reach beyond the genome and into what's known as the epigenome -- proteins and small molecules that latch onto DNA and control when and where genes are switched on or off.

19 Apr 2021

Study shows how stem cells make specific types of cells

With the help of a novel single-cell technique, researchers from the Walter and Eliza Hall Institute (WEHI) have revealed a new way to interpret the programming behind stem cells and how these cells make specific types of cells.

From Walter and Eliza Hall Institute of Medical Research (WEHI) 16 Apr 2021

Growing chimeric embryos could offer new insights into developmental biology, evolution

Scientists from China and the United States have been able to grow chimeric embryos for a considerable period of time—of up to 20 days—by injecting human stem cells into primate embryos.

16 Apr 2021

INRS professor receives $700,000 for research on bacteria of the nasopharynx

Professor Frédéric Veyrier of the Institut national de la recherche scientifique (INRS) has received $711,450 from the Canadian Institutes of Health Research (CIHR) for a project on bacteria of the nasopharynx, including Neisseria.

16 Apr 2021

Study reveals how some antibodies can effectively disable ebolaviruses

Some survivors of ebolavirus outbreaks make antibodies that can broadly neutralize these viruses--and now, scientists at Scripps Research have illuminated how these antibodies can disable the viruses so effectively. The insights may be helpful for developing effective therapies.

16 Apr 2021

Modified immune cells can ruthlessly kill cancerous tumors

Modified immune cells that ruthlessly kill cancerous tumors may prove a game-changer for people living with late-stage cancer.

16 Apr 2021

DNAJC9 protein plays a key role in protecting histones in the cell nucleus

Histones play an important role in the cell nucleus by packaging DNA into chromatin.

15 Apr 2021

Study reveals RNA regulatory mechanisms within transcription-translation couplings

To gain a better understanding of how bacterial RNA gives rise to proteins scientists are now focusing on the special way this process takes place in bacteria.

15 Apr 2021

Ebola virus protein changes shape by using human RNA

The human genome contains the instructions to make tens of thousands of proteins. Each protein folds into a precise shape--and biologists are taught that defined shape dictates the protein's destined function. Tens of thousands of singular shapes drive the tens of thousands of needed functions.

15 Apr 2021

Scientists characterize the genetic diversity of populations in the South Pacific

Describing the genetic diversity of human populations is essential to improve our understanding of human diseases and their geographical distribution.

From Institut Pasteur 15 Apr 2021

Cell News and Research

Chaperone protein imbalance initiates toxic accumulation of tau in the aging brain

Researchers uncover a key genetic culprit in the development of acute lymphoblastic leukemia

Study highlights the importance of autophagy in gene regulation

Key discovery could prevent treatment failure in people with severe hemophilia A

Study shows how tau aggregates promote Alzheimer’s disease

Interferon-stimulating genes control SARS-CoV-2 replication

Antibodies may not inhibit SARS-CoV-2 variants from minks

3D biomaterial helps implanted stem cells stick around to reverse arthritis

Supercomputer simulations reveal the behavior of dominant G form SARS-CoV-2 strain

New breakthrough in understanding the role of high-risk immune genes in rheumatoid arthritis

New CRISPR technology allows scientists to switch off any gene in human cells

Study shows how stem cells make specific types of cells

Growing chimeric embryos could offer new insights into developmental biology, evolution

INRS professor receives $700,000 for research on bacteria of the nasopharynx

Study reveals how some antibodies can effectively disable ebolaviruses

Modified immune cells can ruthlessly kill cancerous tumors

DNAJC9 protein plays a key role in protecting histones in the cell nucleus

Study reveals RNA regulatory mechanisms within transcription-translation couplings

Ebola virus protein changes shape by using human RNA

Scientists characterize the genetic diversity of populations in the South Pacific

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