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Using genetic engineering to grow synthetic livers

Using genetic engineering to grow synthetic livers

News-Medical talks to Dr. Mo Ebrahimkhani about his research using genetic engineering together with a machine-learning algorithm to mature a lab-grown 'designer liver organoid'.

From University of Pittsburgh 15 Dec 2020

New combination therapy could be effective in treating aggressive cancers with common mutations

New combination therapy could be effective in treating aggressive cancers with common mutations

Scientists have long known that therapies that target the cancer-driving MAPK pathway are only effective in a handful of cancers with specific mutations in a cancer gene called BRAF, and these cancers that initially respond to the therapy often end up developing resistance to the treatment, resulting in relapse for many patients.

15 Dec 2020

Newly identified diagnostic marker can help overcome treatment resistance in cervical cancer

Newly identified diagnostic marker can help overcome treatment resistance in cervical cancer

Scientists from the University of California, Los Angeles have discovered a promising diagnostic marker that may help predict the response of cervical cancer patients to standard radiation and chemotherapy treatments.

14 Dec 2020

New analysis technique could pave way for major breakthroughs in immunotherapy

New analysis technique could pave way for major breakthroughs in immunotherapy

In a new study, researchers at Uppsala University have been able to show differences in how Rituximab, a monoclonal antibody drug, interacts with the blood of healthy individuals compared to patients with chronic lymphatic leukaemia.

14 Dec 2020

Study elucidates genes responsible for Glioblastoma invasiveness

Study elucidates genes responsible for Glioblastoma invasiveness

One of the hallmarks of Glioblastoma (GBM), the most aggressive type of brain cancer, is its high invasive capacity, which leads to its expansion into the normal brain tissue.

14 Dec 2020

Researchers discover protein crucial for growing life-saving blood stem cells

Researchers discover protein crucial for growing life-saving blood stem cells

A group of scientists from the Centre for Genomic Regulation (CRG) in Barcelona and Columbia University in New York City has discovered a protein that is crucial for expanding the usually scarce, life-saving blood stem cells.

11 Dec 2020

New method uses artificial intelligence to study live cells

New method uses artificial intelligence to study live cells

Researchers have developed a new technique that combines label-free imaging with artificial intelligence to visualize unlabeled live cells over a long time.

11 Dec 2020

Revolutionary CRISPR-based genome editing system treatment destroys cancer cells

Revolutionary CRISPR-based genome editing system treatment destroys cancer cells

Researchers at Tel Aviv University have demonstrated that the CRISPR/Cas9 system is very effective in treating metastatic cancers.

11 Dec 2020

New model helps assess the effect of epigenetic changes on gene expression

New model helps assess the effect of epigenetic changes on gene expression

Researchers have developed a mathematical model to quantitatively assess the impacts of particular epigenetic changes on the transcription rates.

11 Dec 2020

Newly identified Cas9 nucleases can improve genome editing

Newly identified Cas9 nucleases can improve genome editing

Scientists have explained two new compact Cas9 nucleases that will possibly extend the Cas9 toolbox for genome editing.

11 Dec 2020

A genetic shortcut to help visualize proteins at work

A genetic shortcut to help visualize proteins at work

A group at Gladstone Institutes and UC San Francisco (UCSF) has demonstrated that a large-scale and systematic genetic approach can indeed yield reliable and detailed information on the structure of protein complexes.

11 Dec 2020

Research shows how microbubbles can be used to administer potent cancer drugs

Research shows how microbubbles can be used to administer potent cancer drugs

New research has shown how microbubbles carrying powerful cancer drugs can be guided to the site of a tumour using antibodies.

11 Dec 2020

Study shows how microplastics are internalized into living cells

Study shows how microplastics are internalized into living cells

Microplastics have polluted the global environment. These minute particles enter food chains, and end up in the digestive systems of humans and animals.

11 Dec 2020

Study reveals new target to make breast cancer more sensitive to immunotherapy

Study reveals new target to make breast cancer more sensitive to immunotherapy

Although immunotherapy has been effective in treating different kinds of cancer, it is still unsuccessful when it comes to treating breast cancers.

11 Dec 2020

Study reveals novel dimension in the study of protein-protein interactions

Study reveals novel dimension in the study of protein-protein interactions

Many proteins are required to maintain the structure, and to preserve the genetic integrity, of DNA. Sliding clamps are proteins that increase the efficiency of DNA replication.

11 Dec 2020

Study shed light on how genes affect the risk for coronary artery disease

Study shed light on how genes affect the risk for coronary artery disease

Researchers at the University of Virginia have shed light on how our genes affect our risk for coronary artery disease, the most common form of heart disease.

11 Dec 2020

Researchers identify new therapeutic target to treat type 1 diabetes

Researchers identify new therapeutic target to treat type 1 diabetes

Scientists from the University of Utah School of Medicine have discovered a novel therapeutic target to treat type 1 diabetic patients.

10 Dec 2020

Scientists use honey bee peptide to design RBC carriers that deliver therapeutic proteins

Scientists use honey bee peptide to design RBC carriers that deliver therapeutic proteins

Most often, protein therapies are more selective and potent toward their biochemical targets when compared to other types of medicines, specifically small molecules.

10 Dec 2020

Hydrogen peroxide protects the intestinal lining from gut microbes

Hydrogen peroxide protects the intestinal lining from gut microbes

Scientists at UC Davis Health have discovered that an enzyme in the colon lining releases hydrogen peroxide (H2O2) - a known disinfecting compound- to protect the body from gut microbes.

From The University of California, Davis 10 Dec 2020

Study sheds light on molecular underpinnings of long-term memory

Study sheds light on molecular underpinnings of long-term memory

On a late summer day in 1953, a young man who would soon be known as patient H.M. underwent experimental surgery.

From Harvard Medical School 10 Dec 2020