Cell Biology

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Random Versions of Human Genomes Created to Unlock Disease Mechanisms

The most complex engineering of human cell lines ever has been achieved by scientists, revealing that our genomes are more resilient to significant structural changes than was previously thought.

3 Feb 2025

First Cell Atlas of Focal Cortical Dysplasia Offers New Insights for Treatment

Using a single-cell sequencing technique, Brazilian researchers have created the first cell atlas of focal cortical dysplasia (FCD), a malformation of the cerebral cortex that leads to drug-resistant epilepsy.

31 Jan 2025

Research Paves Way for Off-the-Shelf CAR T Cells for Cancer Treatment

CAR T cell therapy is one of the most promising new cancer treatments to emerge in recent years. It involves removing a patient's own immune T cells and engineering them to recognize specific targets on the surface of the cancer cell.

31 Jan 2025

Human Cell Lines Reveal Genome's Tolerance to Structural Variation

The most advanced engineering of human cell lines to date has been accomplished by scientists, demonstrating that genomes are more robust against significant structural changes than previously understood.

31 Jan 2025

Novel Chemo-Optogenetic Systems Offer Spatiotemporal Precision

A research team at Umeå University has created advanced light-controlled tools that allow for precise regulation of proteins in real time within living cells.

31 Jan 2025

EpiBERT AI Model Reveals How Genes Are Regulated in Human Cells

A team of investigators from Dana-Farber Cancer Institute, The Broad Institute of MIT and Harvard, Google, and Columbia University have created an artificial intelligence model that can predict which genes are expressed in any type of human cell.

30 Jan 2025

Durham University Researchers Unveil Tool to Predict Protein Metalation

Researchers at Durham University have achieved a major advancement in understanding how proteins bind metals inside cells, a process crucial to life.

30 Jan 2025

Temperature-Sensitive Protein Enables Non-Invasive Control of Cellular Behavior

Imagine being at a big marquee event at an arena, like the Super Bowl, with the roar of the crowd, the smell of hot dogs, and a sea of jerseys all merging into one chaotic blur.

30 Jan 2025

Scientists Create First Healthy Mice with Two Fathers

A group of stem cell researchers has successfully engineered embryonic stem cells to create a bi-paternal mouse, a mouse with two male parents, that survived to adulthood.

29 Jan 2025

New Lipids Dramatically Improve Gene Therapy and Vaccine Delivery

Every time a shuttle docks with the International Space Station (ISS), a precise and intricate process takes place between the shuttle’s docking system and its counterpart on the station

29 Jan 2025

Unraveling the Role of Cyclin B Docking in Regulating Cell Division

Cell division is essential for the survival of all living organisms, from the simplest yeast to complex human beings.

29 Jan 2025

New Method Helps T Cells Live Longer and Fight Cancer More Effectively

Researchers from the University of Pittsburgh have developed a new way to grow T cells in the lab that enables them to live longer and better destroy cancer cells in a mouse model of melanoma compared to those grown in traditional growth media.

29 Jan 2025

New Consensus Paper Advances Nomenclature for Mitochondria Transfer and Transplantation

Most animal, plant and fungal cells contain organelles called mitochondria. These descendants of a primordial bacterial endosymbiont still preserve distinct genes and are known for their ability to create ATP as chemical energy.

28 Jan 2025

Fast and Precise Protein Labeling in Intact Tissues with MIT Technology

A new technology developed at MIT enables scientists to label proteins across millions of individual cells in fully intact 3D tissues with unprecedented speed, uniformity, and versatility.

27 Jan 2025

Mitochondrial Calcium Imbalance Drives Neurodegeneration

Mitochondria are crucial organelles for cellular homeostasis, regulating processes such as ATP production, reactive oxygen species (ROS) management and Ca2+ signaling.

27 Jan 2025

Research Identifies Key Immune Cells for Liver Repair

Our livers contain many different types of immune cells. New research by the team of Prof. Charlotte Scott (VIB-UGent Center for Inflammation Research) and colleagues now reveals that a specific activation state of one of these cell types is required for tissue repair following injury.

27 Jan 2025