Cell Biology

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Each person's gut has a unique viral 'fingerprint'

Each person's gut virus composition is as unique as a fingerprint, according to the first study to assemble a comprehensive database of viral populations in the human digestive system.

25 Aug 2020

Lasting nature of IBD linked to long-lived immune cell that causes persistent inflammation

Inflammatory bowel disease (IBD) is a group of intestinal disorders affecting an estimated six to eight million people worldwide.

25 Aug 2020

Rare disorder of fat metabolism can cause chronic hyperreaction of the immune system

A congenital disorder of the fat metabolism can apparently cause chronic hyperreaction of the immune system. This is the conclusion reached by researchers from the University of Bonn in a recent study.

25 Aug 2020

STING protein activates a pathway that kills tumor-fighting immune cells

The immune protein STING has long been noted for helping protect against viruses and tumors by signaling a well-known immune molecule. Now, UT Southwestern scientists have revealed that STING also activates a separate pathway, one that directly kills tumor-fighting immune cells.

25 Aug 2020

Fault in RNA quality control system causes haywire production of toxic proteins

Osaka, Japan - Researchers at Osaka University have identified a fault in the RNA quality control system of cells that leads to the haywire production of toxic proteins in frontotemporal lobar degeneration and amyotrophic lateral sclerosis (FTLD/ALS).

From Osaka University 25 Aug 2020

Study reveals cellular and molecular mechanisms of hypoxic stress and inflammation

Ion channels, transports, and membrane receptors are immediately delivered to defined cellular membranes once they are synthesized in the cytoplasm.

24 Aug 2020

Study shows Annexin molecule promotes resistance to anticancer drugs

Headed by Kumamoto University (Japan), a collaborative study has identified a novel mechanism for anticancer drug resistance in gastric cancer.

24 Aug 2020

Researchers identify a novel molecular mechanism of intestinal stem cells

Stem cells in the intestines maintain an excellent balance between two promising forms—developing into intestinal epithelial cells, or remaining as stem cells.

24 Aug 2020

Study shows how DUSP8 protein regulates glucose tolerance, insulin sensitivity

The brain plays a major role in controlling our blood glucose levels. In type 2 diabetics this glucose metabolism brain control is often dysfunctional. Genetic components for this phenomenon have so far remained elusive.

24 Aug 2020

New bioluminescent reporter tracks DNA double stranded break repair in cells

A new bioluminescent reporter that tracks DNA double stranded break (DSB) repair in cells has been developed by researchers from Massachusetts General Hospital (MGH) and the Academia Sinica in Taiwan.

24 Aug 2020

Study provides a SnapShot of FABP proteins linked to obesity

Fatty acid-binding proteins (FABPs), function as a kind of chaperone, synchronizing the transport of various molecules, including fatty acids, between cells.

24 Aug 2020

Study sheds new light on crucial proteins linked to genetic diseases

A new study offers a better understanding of the properties of important proteins found inside the ciliary membrane.

24 Aug 2020

Eliminating tumors with engineered ‘off-the-shelf’ therapeutic T cells

Personalized cancer treatments are no longer just options of the future. In the past few years, researchers have made significant progress in 'teaching' the body's immune T cells to recognize and kill specific cancer cells, and human clinical trials have shown that this approach can successfully eliminate tumors

21 Aug 2020

A metabolic enzyme could be potential target for immunotherapies

The metabolic enzyme IL4I1 (Interleukin-4-Induced-1) promotes the spread of tumor cells and suppresses the immune system.

21 Aug 2020

Study offers promising data for improved treatments for cardiac disease

A group of researchers have recently published an article that provides promising data for enhanced therapeutic treatments for cardiac disease.

20 Aug 2020

Study shows how PIM kinases enhance the motility of cancer cells

PIM kinases are essentially enzymes that support the metastatic growth and proliferation of tumor cells.

20 Aug 2020

Newly developed transplantable human cells can help cure type 1 diabetes

Researchers have made a significant advancement in the quest for a safe, effective treatment for type 1 diabetes.

20 Aug 2020

Small set of genes may help decide the identity of every neuron in worms

When it comes to brain cells, one size does not fit all. Neurons come in a wide variety of shapes, sizes, and contain different types of brain chemicals.

20 Aug 2020

Improving the accuracy of DNA melt curve

DNA is not only the blueprint of life, it has become the backbone for making tiny structures that can be inserted into the human body to diagnose and treat disease.

20 Aug 2020

Cytokine storms in COVID-19 patients may prevent the development of long-term immunity

Shiv Pillai, MD, Ph.D., investigator in the Ragon Institute of MGH, MIT and Harvard and professor at Harvard Medical School (HMS), recently published a paper in Cell showing that that high levels of some cytokines seen in COVID-19 patients, as part of a cytokine storm, may prevent the development of long-term immunity to SARS-CoV-2, the virus that causes COVID-19.

20 Aug 2020