Genomics

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New Cloaked CRISPR Technology Reveals Hidden Gene Targets for Cancer Metastasis

The immune system plays a crucial role in fighting tumors and metastases. Consequently, it is decisive to conduct cancer research in mouse models with an immune system that is as natural as possible – which is easier said than done.

21 Nov 2025

Chaperone-Shielding Mechanism Regulates Protein Glycosylation

Proteins are often called the building blocks of cells, but even those building blocks need to be built. One of the most important steps in the process of building proteins is glycosylation, when sugar molecules (glycans) are attached to the maturing protein.

20 Nov 2025

Genetic Insights Reveal Key Drivers of Bone Density in Children

Researchers at Children's Hospital of Philadelphia (CHOP) revealed important genetic components that affect bone density in children and adolescents.

20 Nov 2025

Discovery Reveals Greater Epigenetic Complexity in Unicellular Life

Multicellular organisms (animals, plants, human) all have the ability to methylate the cytosine © base in their DNA. This process, a type of epigenetic modification, plays an important role in conditions such as cancer and processes such as aging.

19 Nov 2025

Neurons and Other Nondividing Cells Respond Differently to CRISPR-Cas9 Gene Editing

The gene editing tool known as CRISPR-Cas9 is changing what's possible for treating a wide range of diseases caused by genetic mutations.

18 Nov 2025

CRISPR Gene Editing Reverses Chemotherapy Resistance in Lung Cancer

In a major step forward for cancer care, researchers at ChristianaCare's Gene Editing Institute have shown that disabling the NRF2 gene with CRISPR technology can reverse chemotherapy resistance in lung cancer. The approach restores drug sensitivity and slows tumor growth.

18 Nov 2025

Optical Genome Mapping Reveals Overlooked Causes of Pregnancy Loss

Pregnancy loss may occur in as many as 25% of all pregnancies. Most of these losses occur in the first trimester, and about half are caused by genetic or chromosomal issues.

18 Nov 2025

Exploring Carotenoid Diversity in Carrots Through Gene Editing

Carrots are rich in carotenoids, essential for human health, providing important compounds like vitamin A.

17 Nov 2025

Targeted Genetic Testing Revolutionizes Diagnosis of X-Linked Dystonia-Parkinsonism

Scientists at Brigham and Women's Hospital and Harvard Medical School have developed a targeted genetic test to improve diagnosis for X-linked dystonia-parkinsonism (XDP), a rare and disabling movement disorder that affects primarily men of Filipino ancestry.

17 Nov 2025

Reviving Ancient DNA Techniques to Study Historical Disease Evolution

Research institutions around the world house valuable genetic information that could help unlock countless medical mysteries.

17 Nov 2025

Understanding Genetic Diversity Through Short Tandem Repeats

Scientists at The Hospital for Sick Children (SickKids) have revealed a previously overlooked layer of genetic variation that could help explain why people experience disease differently, and why some treatments work better for certain populations.

17 Nov 2025

New "Ultra-Mild" Method Corrects Cancer DNA Methylation Test Errors

Traditional bisulfite sequencing damages DNA, while enzyme-based alternatives are inconsistent. A novel methylation analysis method, called UMBS-seq, was published this week in Nature Communications. UMBS-seq achieves both accuracy and gentleness, unlocking more reliable cancer biomarker detection.

13 Nov 2025

Texas A&M Researchers Use AI to Identify a Genetic Time Capsule for Distinguishing Species

In a groundbreaking study, scientists from the Texas A&M College of Veterinary Medicine and Biomedical Sciences (VMBS) have utilized cutting-edge artificial intelligence methods to identify a region of the X chromosome that has maintained the distinctiveness of mammal species for millions of years.

13 Nov 2025

Animals Evolved Similar Genetic Tools to Conquer Land Across Distant Lineages

Animals from completely different branches of the tree of life such as insects, worms and vertebrates independently evolved similar genetic solutions to survive on land, according to a new study from researchers at the University of Bristol and University of Barcelona.

13 Nov 2025

Rethinking Model Organisms to Harness Nature’s Untapped Diversity

Recent epic leaps in genetics have created a biodiversity library. As the genetic make-up of animals, plants, fungi, bacteria, and viruses has been mapped, researchers racing to develop solutions to today's global challenges run into a question: Why be limited to a mouse?

12 Nov 2025

Deciphering PARP14's Role in Viral Pathogenesis

Researchers at the University of Kansas have identified that the human gene encoding the protein PARP14 plays a crucial role in regulating interferon, a key component of the body’s innate immune system.

12 Nov 2025

Pitt-Led Team Creates Fully Synthetic Bacteriophages, Speeding Up Discovery

A team led by University of Pittsburgh's Graham Hatfull has developed a method to construct bacteriophages with entirely synthetic genetic material, allowing researchers to add and subtract genes at will. The findings open the field to new pathways for understanding how these bacteria-killing viruses work, and for potential therapy of bacterial infections.

11 Nov 2025

Study Exposes Critical Security Flaws in Widely Used DNA Sequencing Tech

Portable genetic sequencers used around the world to sequence DNA have critical, previously unreported security vulnerabilities that could reveal or alter genetic information without detection, according to a new study.

11 Nov 2025

Neanderthal DNA Reveals Secrets of Jaw Development

Every human face is unique, allowing us to distinguish between individuals. We know little about how facial features are encoded in our DNA, but we may be able to learn more about how our faces develop by looking at our ancient relatives, the Neanderthals.

11 Nov 2025