Genomics

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Study Challenges Longstanding Mitochondrial Theory of Aging

The human genome is broadly classified into the genome residing in the cell nucleus (nuclear DNA) and the genome residing in the mitochondria (mitochondrial DNA: mtDNA). Mitochondria are cell organelles that produce energy essential for life activities through oxidative phosphorylation (mitochondrial respiration), and mtDNA encodes a set of genes required for mitochondrial respiration.

27 May 2025

Mutation Profiling Reveals Therapeutic Targets in Lung Squamous Cell Carcinoma

Lung Squamous cell carcinoma (LSCC) represents the second most common non-small cell lung cancer. Although studies identified adenocarcinoma-like driver mutations in LSCC using next-generation sequencing (NGS), the disease is challenging to treat due to the limited number of detectable mutations for targeted drug therapy.

27 May 2025

Study Reveals How Genetic Differences in TRIO Affect Neurodevelopment

Researchers have identified how variations in a gene called TRIO can influence brain functions and result in distinct neurodevelopmental diseases.

24 May 2025

Broad Spectrum Pathogen Detection Achieved Through Metagenomic Sequencing

A recent study on the application of Metagenomic next-generation sequencing (mNGS) found that mNGS can achieve early detection of pathogens and accelerate the development of targeted anti-infection treatment plans, thereby improving treatment outcomes and patient prognosis.

24 May 2025

RNA Editing and Transcriptional Switching Shape Fungal Antiviral Response

The expression of symptoms of viral infections is a byproduct of complex virus-host molecular pathways. These remain largely unknown, especially in the case of fungus-virus pathogen systems.

24 May 2025

Machine Learning Reveals Molecular Profile Differences in Colorectal Cancer Patients

Scientists aiming to advance cancer diagnostics have developed a machine learning tool that is able to identify metabolism-related molecular profile differences between patients with colorectal cancer and healthy people.

24 May 2025

New Genomic Score Predicts Risk of Progression in Multiple Myeloma

A new risk assessment score developed by researchers at Dana-Farber Cancer Institute and the Broad Institute of MIT and Harvard reveals how multiple myeloma, a form of blood cancer, begins and progresses from precancerous to malignant states by tracing DNA mutations.

24 May 2025

Gene Loss and Gain Shaped the Evolution of Relapsing Fever Bacteria

Researchers at the Francis Crick Institute and UCL have analyzed ancient DNA from Borrelia recurrentis, a type of bacteria that causes relapsing fever, pinpointing when it evolved to spread through lice rather than ticks, and how it gained and lost genes in the process.

24 May 2025

Study Reveals How Introns Multiply and Move Across Genomes

DNA is the genetic code that provides the biological instructions for every living species, but not every bit of DNA helps the species survive. Some pieces of DNA are more like parasites, along for the ride and their own survival.

24 May 2025

Reversible DNA Modification Controls Replication and Gene Activity

Study uncovers ADP-ribosylation's role in Mycobacterium tuberculosis, showing how DNA modification controls replication and gene expression for survival.

23 May 2025

Study Reveals Epigenetic Clues Behind Autism Development

Autism spectrum disorder (ASD) is a condition affecting the brain's development and often affects the ability of a person to perceive sensory information and social cues and socialize with others.

22 May 2025

Study Reveals Genetic Predisposition to Long COVID Near Lung-Related Gene

A global group of scientists has discovered a genetic connection to persistent COVID-19 symptoms.

22 May 2025

New CRISPR Technology for Precise RNA Delivery in Neurons

Proteins produced by RNA segments can aid in the repair of damaged neurons in human bodies.

22 May 2025

Unraveling the Co-Evolution of Human Height and Basal Metabolic Rate

Taller stature and a higher basal metabolic rate are two characteristics that distinguish modern humans from non-human primates. A genetic variant that helped these traits co-evolve was discovered by researchers and published in Cell Genomics.

22 May 2025

Ultra-Rapid Genetic Test Revolutionizes Brain Tumor Diagnosis

Scientists and medics have developed an ultra-rapid method of genetically diagnosing brain tumors that will cut the time it takes to classify them from 6-8 weeks, to as little as two hours – which could improve care for thousands of patients each year in the UK.

21 May 2025