Genomics

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Spatial Transcriptomics Reshapes Musculoskeletal Research and Therapy

Conventional transcriptomic techniques have revealed much about gene expression at the population and single-cell level—but they overlook one crucial factor: spatial context.

10 Jun 2025

A New Strategy for High-Fidelity CRISPR Editing in Tomatoes

Gene targeting (GT) via homologous recombination (HR) is a powerful tool for precise genome editing, but its application in plants is limited due to the dominance of canonical non-homologous end-joining (cNHEJ) in double-strand break (DSB) repair.

10 Jun 2025

Giant Viruses Discovered to Influence Marine Ecosystems and Algal Blooms

Giant viruses play a role in the survival of single-celled marine organisms called protists. These include algae, amoeba, and flagellates, that form the base of ocean food webs.

9 Jun 2025

Mapping the Genetic Blueprint of Flowering Chinese Cabbage

Flowering Chinese cabbage (Brassica rapa ssp. chinensis var. parachinensis), known for its tender stalks and vibrant greens, has long been a dietary mainstay in southern China and beyond.

9 Jun 2025

Unraveling the Genetic Roots of Anemia in Inflammatory Bowel Disease

One of the most frequent side effects of inflammatory bowel disease, or IBD, is iron deficiency and anemia, which can be made worse by a genetic mutation linked to Crohn’s disease, according to a study conducted by biomedical scientists at the University of California, Riverside School of Medicine.

9 Jun 2025

Zebrafish Model Offers Hope for Treating Ultra-Rare Muscle Disease

Can a small fish help identify possible treatments for an ultra-rare inherited disease found in an Alabama boy? The genetic disease is XMEA, which progressively weakens the muscles and can affect the liver and heart.

6 Jun 2025

Breakthrough Gene Discovery Uncovers a Master Switch for Food Intake

The Gpr45 gene is linked to food intake regulation, offering insights for obesity therapies. Study utilizes Automated Meiotic Mapping for gene identification.

6 Jun 2025

UC Davis Study Links Specific microRNAs to Mental and Neurological Disorders

A study in Nature Aging from researchers at the UC Davis School of Medicine has identified specific microRNAs - non-coding RNAs that regulate gene expression within cells - that likely contribute to bipolar disorder, depression, schizophrenia, post-traumatic stress disorder (PTSD) and Parkinson's disease.

5 Jun 2025

Base Editing Breakthrough Brings Hope for Genetic Disease Treatment

You may have seen it in the news recently: a baby in Pennsylvania with a rare genetic disorder was healed with a personalized treatment that repaired his specific genetic mutation.

5 Jun 2025

Ochsner Health Shares Blueprint for Integrating Pharmacogenomics into Clinical Practice

In a report recently published in the American Journal of Health-System Pharmacy, the Ochsner Health system delves into the multifaceted implementation of pharmacogenomics-a rapidly evolving field that examines how genetics influence individual responses to medication.

5 Jun 2025

Novel RNAs from Jumping Genes Produce Reverse Transcriptase Activity in Aging Neurons

Alzheimer's disease is the most common cause of dementia and affects more than a tenth of Americans aged 65 and older.

5 Jun 2025

New Study Details H9N2 Avian Flu’s Variability and Public Health Implications

Research on H9N2 avian influenza shows extensive genetic changes, raising public health concerns and emphasizing the need for enhanced monitoring and vaccines.

4 Jun 2025

Gene Editing Using CRISPR and AAV6 Impacts Long-Term Regeneration of Blood Stem Cells

Scientists at the San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), Milan, have found that gene editing using CRISPR-Cas9 in combination with AAV6 vectors can trigger inflammatory and senescence-like responses in blood stem cells, compromising their long-term ability to regenerate the blood system.

4 Jun 2025

Canine DNA Reveals New Genes Linked to Gastric Cancer In Humans

Dogs share our homes, our habits and sometimes, our diseases. Gastric cancer is rare in dogs, but when it does strike, it closely resembles gastric cancer in humans: subtle clinical signs, comparable tumor subtypes, late-stage diagnosis and poor outcomes.

3 Jun 2025

Evolution of Cancer Genomes During Metastasis

Research on cancer metastasis uncovers genetic complexities, showing that copy-number alterations play a key role in tumor evolution and treatment resistance.

3 Jun 2025

Exon-Specific Analysis Uncovers Novel Insights into Psychiatric Disease

This research highlights the role of exons in mental illnesses, offering new perspectives on genetic factors that influence psychiatric disorder development.

3 Jun 2025

Large Language Models Unlock New Frontiers in Plant Genomics

By leveraging the structural parallels between genomic sequences and natural language, these AI-driven models can decode complex genetic information, offering unprecedented insights into plant biology.

2 Jun 2025

New Genome Assembly Sheds Light on Tropical Vine's Invasive Success

Merremia boisiana, a member of the Convolvulaceae family, a fast-growing vine native to tropical rainforests and known for its vibrant golden flowers and astonishing climbing ability, grows at speeds exceeding 12 cm per day, often overwhelming native vegetation and disrupting forest ecosystems.

2 Jun 2025

Common Genetic Variation Doubles Dementia Risk in Men, Study Finds

Research reveals men with a genetic variant may face double the dementia risk compared to women, highlighting the need for targeted prevention strategies.

2 Jun 2025

Repairing DNA Double-Strand Breaks May Improve Genomic Stability by Limiting Organelle-to-Nucleus Gene Transfer

A new study in Nature Plants reveals that DNA double-strand break repair (DSBR) pathways help prevent gene transfer from organelles to the nucleus in plants. Disruption of DSBR increases the risk of genomic instability through endosymbiotic gene transfer (EGT).

2 Jun 2025