Histology & Microscopy

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Scientists gain fascinating insights into the dynamic ultrastructure of the heart

What happens below the cellular level when the heart contracts and relaxes has long been unexplored. Thanks to new ultra-high-resolution electron microscopy techniques, scientists can now watch the heart beating – almost at a molecular level.

11 Apr 2022

Research sheds light on non-invasive conjunctival goblet cell testing in patients

Conjunctival Goblet Cells (CGCs) are specialized epithelial cells that secrete mucins to generate the tear film’s mucus layer.

11 Apr 2022

Combining organoids and microfluidics to study how the immune system responds to hepatitis C

A vaccine for hepatitis C has eluded scientists for more than 30 years, for several reasons. For one, the virus that causes the disease comes in many genetic forms, complicating the creation of a widely effective vaccine.

7 Apr 2022

Rockefeller scientists reveal how a narrow-spectrum antibiotic selectively targets C. diff

Most antibiotics are double-edged swords. Besides killing the pathogen they are prescribed for, they also decimate beneficial bacteria and change the composition of the gut microbiome.

7 Apr 2022

New technique for better visualizing the CNS fibroblasts

The central nervous system (CNS) consists of several types of cells having varied specialized functions.

7 Apr 2022

High-resolution 3D map reveals cellular structure of the human metathalamus

A new, high-resolution 3D map of a previously unmapped area of the brain has been reconstructed by a team of researchers as part of the Human Brain Project (HBP). The German-based group developed a cytoarchitectonic map (a map of the cellular structure of the brain, down to the individual neurons) of the metathalamus, an area involved in processing audiovisual information.

4 Apr 2022

Researchers discover a unique technique to fight hospital-borne disease

A study team developed an early-stage therapy that sabotages the pump and restores antibiotic efficiency by disclosing the structure of a protein needed by bacteria to pump out antibiotics.

From New York University (NYU) 4 Apr 2022

Research reveals how a building block protein assembles to form poxvirus scaffold

Researchers at the Okinawa Institute of Science and Technology Graduate University have revealed how poxviruses build their scaffold - a temporary protein coat that forms and disappears as the virus matures.

1 Apr 2022

New approach to assess motility and invasive capacity of cancer cells in a tissue section

There are many proteins involved in the spread of cancer. However, some of them are notably difficult to observe in patient tissue samples.

28 Mar 2022

Study finds surprisingly few connections between far-reaching regions of the brain

Understanding how the brain functions, particularly how information is processed during different activities, is difficult without knowing how many axons are in the brain and how many connect different functional regions.

25 Mar 2022

Cryo-electron microscopes help determine how “911” molecule repairs DNA damage

When something unexpected happens with DNA replication, cells call their own form of 911 to stop the process and rectify the problem.

23 Mar 2022

Scientists reveal how 9-1-1 clamp attaches to DNA damage site for initiating effective repair

DNA is often likened to a blueprint. The particular sequence of As, Cs, Gs, and Ts in DNA provides information for building an organism.

22 Mar 2022

Curved shape enables predatory bacteria to efficiently invade, grow and live inside the prey

Scientists have found that a predatory bacterium, capable of invading and consuming harmful bugs such as E.coli and Salmonella, can sculpt its own shape to fit inside its prey.

22 Mar 2022

Researchers use GP2 and UMOD to prevent urinary tract infection

A team led by Karolinska Institute used AI and structural biology to learn more about two similar proteins that protect against bacterial infection in the urinary tract.

16 Mar 2022

Confocal laser scanning microscopy captures high-resolution 3D images of cell division in microalgae

Cell division ensures growth or renewal and is thus vital for all organisms. However, the process differs somewhat in animals, bacteria, fungi, plants, and algae.

8 Mar 2022

Researchers discover new fluorescent DNA label, likely to help detect cancer risk

Scientists develop a new fluorescent label that provides a sharper image of how DNA architecture is disturbed in cancer cells.

From University of Pittsburgh 7 Mar 2022

Researchers design a new imaging approach to accelerate imaging-based research

A new imaging method has been designed and tested by scientists from Johns Hopkins Medicine.

2 Mar 2022

Scientists reveal the spectacular structure of C.difficile's protective armor

The spectacular structure of the protective armor of superbug C.difficile has been revealed for the first time showing the close-knit yet flexible outer layer – like chain mail.

From Newcastle University 28 Feb 2022

Live imaging reveals cells moving into position as the eye develops in fruit fly

The ability of cells to self-organize into specific patterns in tissues that serve a function is a universal feature of life.

23 Feb 2022

Newly developed radio-labeled molecule may be able to pinpoint areas of inflammation

Researchers at The University of Texas MD Anderson Cancer Center have developed a new radio-labeled molecule capable of selectively reacting with certain high-energy radicals that are characteristic of innate immune activity, which may allow a non-invasive approach to monitor inflammation in real time by positron emission tomography (PET) imaging.

22 Feb 2022

Histology & Microscopy

Scientists gain fascinating insights into the dynamic ultrastructure of the heart

Research sheds light on non-invasive conjunctival goblet cell testing in patients

Combining organoids and microfluidics to study how the immune system responds to hepatitis C

Rockefeller scientists reveal how a narrow-spectrum antibiotic selectively targets C. diff

New technique for better visualizing the CNS fibroblasts

High-resolution 3D map reveals cellular structure of the human metathalamus

Researchers discover a unique technique to fight hospital-borne disease

Research reveals how a building block protein assembles to form poxvirus scaffold

New approach to assess motility and invasive capacity of cancer cells in a tissue section

Study finds surprisingly few connections between far-reaching regions of the brain

Cryo-electron microscopes help determine how “911” molecule repairs DNA damage

Scientists reveal how 9-1-1 clamp attaches to DNA damage site for initiating effective repair

Curved shape enables predatory bacteria to efficiently invade, grow and live inside the prey

Researchers use GP2 and UMOD to prevent urinary tract infection

Confocal laser scanning microscopy captures high-resolution 3D images of cell division in microalgae

Researchers discover new fluorescent DNA label, likely to help detect cancer risk

Researchers design a new imaging approach to accelerate imaging-based research

Scientists reveal the spectacular structure of C.difficile's protective armor

Live imaging reveals cells moving into position as the eye develops in fruit fly

Newly developed radio-labeled molecule may be able to pinpoint areas of inflammation

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