Histology & Microscopy

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Rotating microscope can track and measure behavior of ocean organisms

Like spirits passing between worlds, billions of invisible beings rise to meet the starlight, then descend into darkness at sunrise. Microscopic plankton's daily journey between the ocean's depths and surface holds the key to understanding crucial planetary processes, but has remained largely a mystery until now.

18 Aug 2020

Scientists describe the mechanism of action of therapeutic antibodies

Since the late 1990s, immunotherapy has been the frontline treatment against lymphomas where synthetic antibodies are used to stop the proliferation of cancerous white blood cells.

14 Aug 2020

Internal structure of fossilized trilobite eye found to be identical to modern bee eyes

The internal structure of a 429-million-year-old fossilized trilobite eye is almost identical to that of modern bees, according to a study published in Scientific Reports.

14 Aug 2020

State-of-the-art 3D microscopy reveals how human sperms swim

Using state-of-the-art 3D microscopy and mathematics, Dr Hermes Gadêlha from the University of Bristol, Dr Gabriel Corkidi and Dr Alberto Darszon from the Universidad Nacional Autonoma de Mexico, have reconstructed the movement of the sperm tail in 3D with high-precision.

14 Aug 2020

Finned nanoporous materials can speed up molecular transport

Thousands of chemical processes used by the energy industry and for other applications rely on the high speed of catalytic reactions, but molecules frequently are hindered by molecular traffic jams that slow them down.

11 Aug 2020

'Little brain' contains almost 80% of the cerebral cortex’s surface area

When we say someone has a quick mind, it may be in part thanks to our expanded cerebellum that distinguishes human brains from those of macaque monkeys, for example.

3 Aug 2020

'Marie Kondo' enzyme helps fruit fly embryos to clean out maternal proteins

Researchers at the University of Colorado School of Medicine have discovered a protein in fruit fly embryos, dubbed Marie Kondo, that destroys maternal proteins.

29 Jul 2020

Deep learning algorithm can infer molecular alterations in cancer from histology images

Researchers at the University of Chicago Medicine Comprehensive Cancer Center, working with colleagues in Europe, created a deep learning algorithm that can infer molecular alterations directly from routine histology images across multiple common tumor types.

29 Jul 2020

AI algorithm can identify patterns of mutations and prognosis from tumor images

Researchers at EMBL's European Bioinformatics Institute, the Wellcome Sanger Institute, Addenbrooke's Hospital in Cambridge, UK, and collaborators have developed an artificial intelligence algorithm that uses computer vision to analyse tissue samples from cancer patients.

28 Jul 2020

Novel label-free imaging method can differentiate between quiescent and activated T cells

T cells are the immune soldiers at the frontlines of the battle with infiltrating pathogens that seek to cause disease. A new study published in Nature Biomedical Engineering describes a novel label-free imaging technique that can differentiate active T cells from those off duty.

28 Jul 2020

Evaluating the impact of sugary and acidic drinks on tooth enamel

Using atomic force microscopy, researchers have quantitatively assessed the effect of sugary and acidic drinks on human tooth enamel at the nanoscale level.

23 Jul 2020

A novel technique to control and visualize functions of living cells

A research group composed of Professor Takayuki Shibata and his colleagues at Department of Mechanical Engineering, Toyohashi University of Technology has given greater functionalities to atomic force microscopy (AFM).

23 Jul 2020

Researchers image the formation of four-stranded DNA in living human cells

The development of four-stranded DNA has been monitored in the living cells of human beings, enabling researchers to observe its potential role in cancer.

21 Jul 2020

Advanced cryo-EM reveals stunning details of viral RNA replication complex structure

For the first time, scientists at the Morgridge Institute for Research have generated near atomic resolution images of a major viral protein complex responsible for replicating the RNA genome of a member of the positive-strand RNA viruses, the large class of viruses that includes coronaviruses and many other pathogens.

21 Jul 2020

New method reveals the dynamics of HIV Gag-protein lattice structure

Viruses are scary. They invade our cells like invisible armies, and each type brings its own strategy of attack. While viruses devastate communities of humans and animals, scientists scramble to fight back.

17 Jul 2020

Researchers use super-resolution microscopy to study close protein associations

With the advent of super-resolution microscopy, scientists can study close protein associations better than ever before.

10 Jul 2020

Structural analysis of SARS-CoV-2 spike protein offers clues about the virus' evolution

Researchers at the Francis Crick Institute have characterized the structure of the SARS-CoV-2 spike protein as well as its most similar relative in a bat coronavirus. The structures provide clues about how the spike evolved and could help inform vaccine design.

10 Jul 2020