Histology & Microscopy

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Unique mini-microscope enables imaging of brain activity in freely moving mice

Researchers from the University of Minnesota Twin Cities College of Science and Engineering and Medical School have developed a unique head-mounted mini-microscope device that allows them to image complex brain functions of freely moving mice in real time over a period of more than 300 days.

6 Apr 2021

Supercomputer simulations help uncover the mechanism for HIV replication

Viruses lurk in the grey area between the living and the nonliving, according to scientists. Like living things, they replicate but they don't do it on their own. The HIV-1 virus, like all viruses, needs to hijack a host cell through infection in order to make copies of itself.

1 Apr 2021

AI-based software for automatic tracking of cells in microscope videos

In modern basic life science research as well as in drug discovery, recording and analyzing the images of cells over time using 3D microscopy has become extremely important.

31 Mar 2021

Study reveals how lipids and water molecules control 5-hydroxytryptamine receptors

Serotonin, or 5-hydroxytryptamine (5-HT), is a kind of neurotransmitter. 5-HT can regulate multifaceted physiological functions such as mood, cognition, learning, memory, and emotions through 5-HT receptors.

26 Mar 2021

Cryogenic electron microscopy helps visualize 3D structure of complex responsible for gene regulation

A research team has looked inside a human cell to visualize a multi-subunit machine that is responsible for controlling the expression of genes.

15 Mar 2021

Researchers construct smallest and cheapest high-resolution microscope

An international team led by researchers of the University of Barcelona builds the smallest and cheapest high-resolution microscope to date.

10 Mar 2021

Adhesion strength and contractility enable metastatic cancer cells to display adurotactic behavior

Bioengineers at the University of California San Diego and San Diego State University have discovered a key feature that allows cancer cells to break from typical cell behavior and migrate away from the stiffer tissue in a tumor, shedding light on the process of metastasis and offering possible new targets for cancer therapies.

10 Mar 2021

New infrared microscope helps image biological samples at the microscopic level

Scientists have designed a new spectroscopic microscope to optically measure the orientations and conformations of molecules in biological specimens.

9 Mar 2021

Simple buffers can prevent photoblueing effect in microscopy

Advances in fluorescence microscopy make it viable to image molecular complexes or individual molecules in cells with a spatial resolution of up to 20 nm.

1 Mar 2021

Machine learning algorithm helps differentiate benign and premalignant colorectal polyps

A machine learning algorithm helps accurately differentiate benign and premalignant colorectal polyps on CT colonography scans, according to a study published in the journal Radiology.

24 Feb 2021

Study reveals specialized mechanism for translation of mitochondrial genome into proteins

An international collaboration among researchers from Finland, Sweden, UK and the USA has captured ribosomes translating messenger RNA expressed from the maternally inherited mitochondrial genome.

23 Feb 2021

A new method for quantitative single-molecule colocalization analysis

WWU researchers develop a new method for quantitative single-molecule colocalization analysis /Study published in Nature Communications.

17 Feb 2021

New technique reveals natural structure of large enzyme complex

A new technique has revealed the natural structure of specifically massive and complex enzymes.

11 Feb 2021

Researchers study the formation of reinforced, patterned cell walls during proto-xylem development

Trees are by far the tallest organisms on Earth. Height growth is made possible by a specialized vascular system that conducts water from the roots to the leaves with high efficiency, while simultaneously providing stability.

3 Feb 2021

Novel microscopy system for scanless 3D measurement with submicron resolution

The National Institute of Information and Communications Technology (NICT), Tohoku University, Toin University of Yokohama, and Japan Science and Technology Agency (JST) have succeeded in developing a scanless high-speed holographic fluorescence microscopy system with submicron resolution for a 3D space.

1 Feb 2021

Researchers develop novel nanobodies against SARS coronavirus-2

An international research team led by the University of Bonn has identified and further developed novel antibody fragments against the SARS coronavirus-2. These "nanobodies" are much smaller than the classic antibodies used to treat US President Donald Trump, for example.

13 Jan 2021

Scientists show how plants adapt root growth to varying sources of nitrogen

Nitrogen is one of the most essential nutrients for plants. Its availability in the soil plays a major role in plant growth and development, thereby affecting agricultural productivity.

6 Jan 2021

Altered sugar composition impacts cell-to-surface adhesion

Biotechnologists measure the forces with which algae cells adhere to surfaces and move on them. How can cells adhere to surfaces and move on them? This is a question that was investigated by an international team of researchers headed by Prof. Michael Hippler from the University of Münster and Prof. Kaiyao Huang from the Institute of Hydrobiology (Chinese Academy of Sciences, Wuhan, China).

4 Jan 2021

Scientists develop novel approach to acquire fluorescence lifetime images

Fluorescence microscopy is widely used in biochemistry and life sciences because it allows scientists to directly observe cells and certain compounds in and around them. Fluorescent molecules absorb light within a specific wavelength range and then re-emit it at the longer wavelength range.