Histology & Microscopy

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Capturing Viruses in a Lipid Trap

Viruses like influenza A and Ebola invade human cells in a number of steps. In an interdisciplinary approach, research teams from Heidelberg University and Heidelberg University Hospital investigated the final stages of viral penetration using electron tomography and computer simulations.

26 Apr 2023

Membrane-Remodeling Proteins in Cyanobacteria are Similar to Protein Found in Higher Organisms

The cells of living organisms are equipped with proteins that are involved in the shaping and remodeling of cellular membranes, thereby performing important tasks.

26 Apr 2023

Food-Poisoning Bacteria Create Syringe-Like Structures to Inject Toxins Into Intestinal Cells

Researchers at UT Southwestern Medical Center have discovered how a bacterium that infects people after they eat raw or undercooked shellfish creates syringe-like structures to inject its toxins into intestinal cells.

21 Apr 2023

Scientists Develop AI-Based Method for Virtual Staining of Histopathological Tissues

Researchers from the University of Eastern Finland, the University of Turku, and Tampere University have developed an artificial intelligence-based method for virtual staining of histopathological tissue samples as a part of the Nordic ABCAP consortium.

17 Apr 2023

A Nanoplasmonics Approach to Observe Real-Time Production of Cell Secretions

Researchers at the University of Geneva have developed a novel optical imaging approach that provides a four-dimensional view of cell secretions in real-time, including their spatial and temporal dynamics.

13 Apr 2023

Tiny Protein Interacts with Ion Channels to Make Our Eyes Sensitive to Dim Light

Using cryo-electron microscopy and mass spectrometry, researchers from PSI have deciphered the structure of an ion channel found in the eye while it interacts with the protein calmodulin – a structure that has eluded scientists for three decades.

4 Apr 2023

Researchers Explain How a Single Mutation Causes Ataxia

Worldwide, only a handful of patients are known to suffer from episodic ataxia type 6, a neurological disease that causes transient loss of muscle control.

4 Apr 2023

Researchers Uncover a New, Direction-Dependent Friction in Proteins

An interdisciplinary research team of the Institutes of Physical Chemistry and Physics of the University of Freiburg and the Max Planck Institute of Biophysics in Frankfurt-am-Main has discovered a new, direction-dependent friction in proteins called anisotropic friction.

3 Apr 2023

"Visual Biochemistry" Approach to Understand How the BRCA2 Protein Binds and Interacts with DNA

Using a self-built inverted microscope complete with laser optical tweezers to capture DNA, Yale Cancer Center and University of California Davis researchers for the first time created a visualization of the full-length human BRCA2 protein at the single molecule level.

3 Apr 2023

CrestOptics Launches CICERO System to Provide All-in-One Solution for Widefield and Spinning Disk Confocal Microscopy

CrestOptics S.p.A., a manufacturer of high-end microscopy solutions and advanced systems for fluorescence microscopy and diagnostic applications, today announced the launch of its new spinning disk confocal microscope system, CICERO.

3 Apr 2023

UConn Health scientists explain why Shigella bacteria can infect humans but not mice

Shigella bacteria can infect humans but not mice. In the March 29 issue of Nature, a team from UConn Health explains why. Their findings may explain the multifariousness of a key weapon of our immune system.

31 Mar 2023

Determining the structure of protein pumps using cryo-EM

A rare, genetic disorder known as Hailey-Hailey disease causes patches of blisters to develop mainly in the folds of skin under the breasts, in the groin, and the armpits.

29 Mar 2023

Abberior installs state-of-the-art STED microscope at MBC BioLabs supporting biotech entrepreneurs

Abberior, a leading provider of cutting-edge imaging technologies, announced today that they have placed a super-resolution STED microscope at MBC BioLabs, the leading San Francisco Bay Area biotech incubator network.

27 Mar 2023

Wearable microscopes produce real-time images of mouse spinal cord activity

The spinal cord acts as a messenger, carrying signals between the brain and body to regulate everything from breathing to movement.

23 Mar 2023

Using PET and electron microscopy to generate 3D maps of mitochondrial networks in lung tumors

Scientists have long known that mitochondria, the "powerhouses" of cells, play a crucial role in the metabolism and energy production of cancer cells.

16 Mar 2023

Merging cryo-TEM and tomography methods to reveal 3D morphology of dendrites

Documenting the lithiation process in TEM can provide a deep understanding of the electrode degradation mechanism during battery cycling, which enhances material modification for improved performance. The research was guided by Prof. Dong Su (Institute of Physics, Chinese Academy of Sciences).

15 Mar 2023

Significance of astrocyte–neuron interactions in fine-tuning brain function

Humans learn to handle a variety of skilled movements throughout their lives, from driving a car to swinging a tennis racket. Neurons are not the only ones who implement this learning, but a new study from The Picower Institute for Learning and Memory at MIT shows that astrocytes play an important role as well.

From Massachusetts Institute of Technology (MIT) 14 Mar 2023

Neural-network-based image recognition models for examining SCC defects

Scientists from Tokyo Metropolitan University have used machine learning to automate the identification of defects in sister chromatid cohesion. They trained a convolutional neural network (CNN) with microscopy images of individual stained chromosomes, identified by researchers as having or not having cohesion defects. After training, it was able to successfully classify 73.1% of new images. Automation promises better statistics, and more insight into the wide range of disorders which cause cohesion defects.

14 Mar 2023

Researchers track a specialized garbage disposal cell inside lymph nodes for the first time

For almost 140 years, the origin and behavior of an enigmatic cell type inside lymph nodes, called a tingible body macrophage, has remained a mystery.

3 Mar 2023

Nanosatellite paves the way for developing RNA-based medicines

Researchers from Aarhus University and Berkeley Laboratory have designed RNA molecules, that folds into nanoscale rectangles, cylinders, and satellites, and have studied their 3D structure and dynamics with advanced nanotechnological methods.

28 Feb 2023

Histology & Microscopy

Capturing Viruses in a Lipid Trap

Membrane-Remodeling Proteins in Cyanobacteria are Similar to Protein Found in Higher Organisms

Food-Poisoning Bacteria Create Syringe-Like Structures to Inject Toxins Into Intestinal Cells

Scientists Develop AI-Based Method for Virtual Staining of Histopathological Tissues

A Nanoplasmonics Approach to Observe Real-Time Production of Cell Secretions

Tiny Protein Interacts with Ion Channels to Make Our Eyes Sensitive to Dim Light

Researchers Explain How a Single Mutation Causes Ataxia

Researchers Uncover a New, Direction-Dependent Friction in Proteins

"Visual Biochemistry" Approach to Understand How the BRCA2 Protein Binds and Interacts with DNA

CrestOptics Launches CICERO System to Provide All-in-One Solution for Widefield and Spinning Disk Confocal Microscopy

UConn Health scientists explain why Shigella bacteria can infect humans but not mice

Determining the structure of protein pumps using cryo-EM

Abberior installs state-of-the-art STED microscope at MBC BioLabs supporting biotech entrepreneurs

Wearable microscopes produce real-time images of mouse spinal cord activity

Using PET and electron microscopy to generate 3D maps of mitochondrial networks in lung tumors

Merging cryo-TEM and tomography methods to reveal 3D morphology of dendrites

Significance of astrocyte–neuron interactions in fine-tuning brain function

Neural-network-based image recognition models for examining SCC defects

Researchers track a specialized garbage disposal cell inside lymph nodes for the first time

Nanosatellite paves the way for developing RNA-based medicines

The Exclusome, A New Mammalian "Containter"

Breaking Down the Onso System: PacBio's Genomic Advancement

The Last Piece of Our Genome: Sequencing the Y Chromosome

Latest in Genomics