Histology & Microscopy

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New Microscopy Technique Reveals Unprecedented Details of Amyloid Plaques in Alzheimer's Disease

Researchers from the Universitat Autònoma de Barcelona (UAB), the Karolinska Institute (KI), and the biotechnology company BioArctic, both in Sweden, have combined STED microscopy, a technology that allows super-resolution visualization, and a new antibody recently created to observe the amyloidogenic aggregates characteristic of Alzheimer's disease.

12 Oct 2023

How RNA Regulates Gene Silencing Could Pave Way for Novel Cancer Therapies

Deep inside our cells-;each one complete with an identical set of genes-;a molecular machine known as PRC2 plays a critical role in determining which cells become heart cells, versus brain or muscle or skin cells.

27 Sep 2023

Ultra-High Field 7 Tesla MRI Helps Better Understand How Light Stimulates the Brain

New research conducted at the University of Liège, using ultra-high field 7 Tesla MRI, provides a better understanding of how light stimulates our brain and could provide new insights into how it works.

25 Sep 2023

Novel Imaging Technique Captures Rapid Protein Dynamics

EPFL researchers have created a unique imaging approach for capturing fast protein dynamics.

22 Sep 2023

Brain's Choreography of Movement Unveiled in Zebrafish Study

The zebrafish brain, though simpler than its human counterpart, is a complex network of neurons that engage in a ceaseless dance of electrical activity.

11 Sep 2023

New Insights into MCM8/9 Enzyme Could Lead to Treatments for Infertility and Cancer

Scientific research requires patience. The rewards are not always immediate, and the technology needed does not always exist. Michael A. Trakselis, Ph.D., professor and director of graduate affairs for the Department of Chemistry and Biochemistry at Baylor University, understands this.

30 Aug 2023

AtomAI: New Software Package Uses Deep Learning to Analyze Microscopy Images

Researchers have developed a new software package for analyzing images from electron and scanning probe microscopy.

28 Aug 2023

Cornell Researchers Develop a Multimodal Platform to Image Biohybrids

When considering ways to sustainably generate environmentally friendly products, bacteria might not immediately spring to mind.

31 Jul 2023

'Orphan' Gene may Have Evolved to Give Seahorses Their Unique Brood Pouch

Teleost fish encompass a diverse group, among which seahorses display a unique morphology. The characteristic spines and brood pouch seen in seahorses feature distinctive epithelial cells-;called flame cone cells-;covered by a mucous cap.

25 Jul 2023

New Insights Into How Genes Are Activated

Genetic information contained within DNA has to be read by specific proteins that enable the process of gene activation to begin – but in many cases, these proteins can't access their targets because DNA strands are bundled up to control what genes are used in the wide range of different cell types.

12 Jul 2023

Cryo-EM Reveals Structure of GABA Transporter

Using Cryo-EM, a powerful microscopy technique, researchers at IISc and collaborators have decoded the molecular architecture of a transporter protein controlling the movement of a key neurotransmitter.

7 Jul 2023

Innovative Technique Enables In Vivo Imaging of Intracellular Protein Aggregates

Tau aggregates have become the main study focus for figuring out the mechanisms underlying neurodegeneration since they are a prevalent form of amyloid protein. Tau fibrils and oligomers, among other forms of tau aggregates, have been linked to a variety of neurodegenerative disorders.

21 Jun 2023

First Brain Atlas of Dwarf Cuttlefish

Anything with three hearts, blue blood and skin that can change colors like a display in Times Square is likely to turn heads.

21 Jun 2023

Reengineering the Cellular Synthetic Machinery to Produce Never-Before-Seen Polymers

Synthetic biologists have become increasingly creative in engineering yeast or bacteria to churn out useful chemicals -; from fuels to fabrics and drugs -; beyond the normal repertoire of microbes.

14 Jun 2023

UCL Scientists Visualize the Molecular 'Nano-Machinery' That Causes Cilia to Beat

The first image of the structures that power human cilia – the tiny, hairlike projections that line our airways – has been produced by a team involving UCL researchers and could lead to much-needed treatments for people with rare cilial diseases.

14 Jun 2023

Key Atomic Structures of the Actin Filament Revealed Through Cryo-EM

Actin filaments -; protein structures critical to living movement from single cells to animals -; have long been known to have polarity associated with their physical characteristics, with growing "barbed" and shrinking "pointed" ends.

9 Jun 2023

Identifying How a Particular Riboswitch Regulates its Synthesis

Researchers across the world are in search of ways to combat bacteria that could evade the present arsenal of antibiotics. This is done as a measure to avoid a global health crisis.

2 Jun 2023

Newly Identified Cellular Mechanism Enhances Photosynthesis in Marine Phytoplankton

Take a deep breath. Now take nine more. According to new research, the amount of oxygen in one of those 10 breaths was made possible thanks to a newly identified cellular mechanism that promotes photosynthesis in marine phytoplankton.

1 Jun 2023

Using High-Energy X-Rays to Image Biological Specimens Without Damage

A pollen grain showing the nanofoam within or a diatom with the individual geometric structures inside clearly visible: Using high-energy X-rays from the PETRA III synchrotron light source at DESY, a team led by CFEL scientists Saša Bajt and Henry Chapman has managed to image these structures without damaging them.

31 May 2023

New Algorithm to Improve the Understanding of Protein Movements

Proteins are biological molecules that perform almost all biochemical tasks in all forms of life. In doing so, the tiny structures perform ultra-fast movements.