Histology & Microscopy

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Structural Insights Unmask Novel Adaptations and Functions of Human LINE-1 ORF2

Martin Taylor, MD, PhD, a physician investigator in the Department of Pathology at Massachusetts General Hospital and an instructor in Pathology at Harvard Medical School, is the lead corresponding author of a new study in Nature, Structural Analysis and Inhibition of Human LINE-1 ORF2 Protein Reveals Novel Adaptations and Functions.

20 Dec 2023

Light-Activated "Good Vibrations" can Destroy Cancer Cells

The Beach Boys' iconic hit single "Good Vibrations" takes on a whole new layer of meaning thanks to a recent discovery by Rice University scientists and collaborators, who have uncovered a way to destroy cancer cells by using the ability of some molecules to vibrate strongly when stimulated by light.

20 Dec 2023

Cryo-EM Analysis Uncovers Unexpected Enzymatic Switch in Bacterial Anti-Phage System

Scientists have revealed a never-before-seen phenomenon in a protein: Alone, the enzyme processes DNA and RNA but, when bound to another protein as part of a defense system, interacts with a completely different type of compound to help bacteria commit suicide.

14 Dec 2023

SFU-UBC Collaboration Pushes Frontiers of Cellular Biology With AI-Enhanced Super-Resolution Microscopy

In 2014, the Nobel Prize in Chemistry celebrated the breakthroughs in super-resolution microscopy, a technology that allows us to capture highly detailed images of small parts of cells using fluorescent microscopy.

11 Dec 2023

Revolutionizing Precision in Super-Resolution Microscopy

Cutting-edge super-resolution microscopy techniques can now achieve optical resolutions within the range of a few nm, corresponding to the size of cellular molecules.

4 Dec 2023

Dipsadine Snake Skull Shapes Tell the Tale of Adaptation

By studying the skull shapes of dipsadine snakes, researchers at The University of Texas at Arlington have found how these species of snakes in Central and South America have evolved and adapted to meet the demands of their habitats and food sources.

1 Dec 2023

New Method Allows Scientists to Observe Multiple Signals in Living Cells

Living cells are bombarded with many kinds of incoming molecular signal that influence their behavior.

29 Nov 2023

Fluorescence-Based Actinometers Enable Precise and Versatile Light Intensity Measurements

Accurate measurements of light intensity provide vital data for scientists and everyday applications.

28 Nov 2023

Research Reveals How Gut Bacteria Influence Distant Organs Through Oxytocin Signaling

The gut microbiome, a community of trillions of microbes living in the human intestines, has an increasing reputation for affecting not only gut health but also the health of organs distant from the gut.

3 Nov 2023

Unlocking the Secrets of Memory: Key Protein Regulates Hippocampal Plasticity

Mount Sinai researchers have shed valuable light on the mechanism of a key protein that regulates the plasticity and function of the hippocampus, a key brain region involved in memory and learning, and that decreases with age in mice.

3 Nov 2023

Developing 4D High-Resolution Imaging System to Track Cell Movement

Tracking the dynamic movements of cells is crucial for modeling the intricate cellular interactions involved in organ formation, such as the heart.

31 Oct 2023

New Microscopy Technique Reveals Unprecedented Details of Amyloid Plaques in Alzheimer's Disease

Researchers from the Universitat Autònoma de Barcelona (UAB), the Karolinska Institute (KI), and the biotechnology company BioArctic, both in Sweden, have combined STED microscopy, a technology that allows super-resolution visualization, and a new antibody recently created to observe the amyloidogenic aggregates characteristic of Alzheimer's disease.

12 Oct 2023

How RNA Regulates Gene Silencing Could Pave Way for Novel Cancer Therapies

Deep inside our cells-;each one complete with an identical set of genes-;a molecular machine known as PRC2 plays a critical role in determining which cells become heart cells, versus brain or muscle or skin cells.

27 Sep 2023

Ultra-High Field 7 Tesla MRI Helps Better Understand How Light Stimulates the Brain

New research conducted at the University of Liège, using ultra-high field 7 Tesla MRI, provides a better understanding of how light stimulates our brain and could provide new insights into how it works.

25 Sep 2023

Novel Imaging Technique Captures Rapid Protein Dynamics

EPFL researchers have created a unique imaging approach for capturing fast protein dynamics.

22 Sep 2023

Brain's Choreography of Movement Unveiled in Zebrafish Study

The zebrafish brain, though simpler than its human counterpart, is a complex network of neurons that engage in a ceaseless dance of electrical activity.

11 Sep 2023

New Insights into MCM8/9 Enzyme Could Lead to Treatments for Infertility and Cancer

Scientific research requires patience. The rewards are not always immediate, and the technology needed does not always exist. Michael A. Trakselis, Ph.D., professor and director of graduate affairs for the Department of Chemistry and Biochemistry at Baylor University, understands this.

30 Aug 2023