Histology & Microscopy

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UCLA researchers receive NIH award to develop next-generation versions of miniature microscope

The UCLA creators of a miniature microscope that can be mounted on the heads of lab animals to provide an invaluable view into the brain's inner workings have received a $4 million grant from the National Institutes of Health to develop next-generation versions of their "miniscope."

9 Aug 2022

Scientists develop microscopy technology that observes how new neurons struggle to reach their developmental destination

With organoids to model early growth, scientists employed a developing microscopy technology to observe that new neurons find it hard to reach their developmental goal.

From Massachusetts Institute of Technology (MIT) 1 Aug 2022

Scientists discover the first structures of angiotensin-converting enzyme using cryo-EM

University of Cape Town (UCT) researchers have used cryo-electron microscopy to identify the first complete structures of the human angiotensin-converting enzyme (ACE) (cryo-EM). A protein that controls blood pressure, ACE, is essential for maintaining good heart health.

14 Jul 2022

Researchers use new technique to examine the composition of cell walls from young poplar trees

To optimize biomaterials for reliable, cost-effective paper production, building construction, and biofuel development, researchers often study the structure of plant cells using techniques such as freezing plant samples or placing them in a vacuum.

8 Jun 2022

Study shows how nanotechnology may help for structural research of RNA molecules

Humans live in a world created and managed by RNA—the genetic molecule DNA’s equally important sibling.

3 May 2022

Scientists get a clearer and more accurate image of proteins

Proteins are among the most significant and diverse biomolecules found in living organisms. These strings of amino acids, which take on complex 3-dimensional structures, are required for tissue growth and maintenance, the activation of thousands of biochemical events, and the immune system’s defense against invaders.

3 May 2022

Little-known protein may play a role in frontotemporal lobar degeneration

Scientists have known for years that amyloid fibrils -; fibrous, ropelike structures formed by closely linked protein molecules -; are present in the brains of patients with Alzheimer's and Parkinson's diseases and likely play a role in the progression of these disorders.

21 Apr 2022

Cryo-EM reveals the structure of fermentation enzyme phosphoketolase

Pharmaceuticals, plastics, and other industries use enzymes to help synthesize molecular feedstocks.

19 Apr 2022

Spatial maps offer insights into the battle between melanoma cells and immune cells

Melanoma is a somewhat unusual cancer-;one that blooms before our very eyes, often on sun-exposed skin, and can quickly become deadly as it turns our own skin against us and spreads to other organs.

From Harvard Medical School 15 Apr 2022

Max Planck researchers reveal the structure of kinetochore corona

During cell division in a mother cell, the 23 chromosomes that carry the human genome must be first copied and later delivered to two newly forming daughter cells.

From The Max Planck Institute 11 Apr 2022

Scientists gain fascinating insights into the dynamic ultrastructure of the heart

What happens below the cellular level when the heart contracts and relaxes has long been unexplored. Thanks to new ultra-high-resolution electron microscopy techniques, scientists can now watch the heart beating – almost at a molecular level.

11 Apr 2022

Research sheds light on non-invasive conjunctival goblet cell testing in patients

Conjunctival Goblet Cells (CGCs) are specialized epithelial cells that secrete mucins to generate the tear film’s mucus layer.

11 Apr 2022

Combining organoids and microfluidics to study how the immune system responds to hepatitis C

A vaccine for hepatitis C has eluded scientists for more than 30 years, for several reasons. For one, the virus that causes the disease comes in many genetic forms, complicating the creation of a widely effective vaccine.

7 Apr 2022

Rockefeller scientists reveal how a narrow-spectrum antibiotic selectively targets C. diff

Most antibiotics are double-edged swords. Besides killing the pathogen they are prescribed for, they also decimate beneficial bacteria and change the composition of the gut microbiome.

7 Apr 2022

New technique for better visualizing the CNS fibroblasts

The central nervous system (CNS) consists of several types of cells having varied specialized functions.

7 Apr 2022

High-resolution 3D map reveals cellular structure of the human metathalamus

A new, high-resolution 3D map of a previously unmapped area of the brain has been reconstructed by a team of researchers as part of the Human Brain Project (HBP). The German-based group developed a cytoarchitectonic map (a map of the cellular structure of the brain, down to the individual neurons) of the metathalamus, an area involved in processing audiovisual information.

4 Apr 2022

Histology & Microscopy

UCLA researchers receive NIH award to develop next-generation versions of miniature microscope

Scientists develop microscopy technology that observes how new neurons struggle to reach their developmental destination

Scientists discover the first structures of angiotensin-converting enzyme using cryo-EM

Researchers use new technique to examine the composition of cell walls from young poplar trees

Study shows how nanotechnology may help for structural research of RNA molecules

Scientists get a clearer and more accurate image of proteins

Little-known protein may play a role in frontotemporal lobar degeneration

Cryo-EM reveals the structure of fermentation enzyme phosphoketolase

Spatial maps offer insights into the battle between melanoma cells and immune cells

Max Planck researchers reveal the structure of kinetochore corona

Scientists gain fascinating insights into the dynamic ultrastructure of the heart

Research sheds light on non-invasive conjunctival goblet cell testing in patients

Combining organoids and microfluidics to study how the immune system responds to hepatitis C

Rockefeller scientists reveal how a narrow-spectrum antibiotic selectively targets C. diff

New technique for better visualizing the CNS fibroblasts

High-resolution 3D map reveals cellular structure of the human metathalamus

Researchers discover a unique technique to fight hospital-borne disease

Research reveals how a building block protein assembles to form poxvirus scaffold

New approach to assess motility and invasive capacity of cancer cells in a tissue section

Study finds surprisingly few connections between far-reaching regions of the brain

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