New computational tool simulates evolution

The building blocks of life-saving therapeutics could be developed in days instead of years thanks to new software that simulates evolution.

Proseeker is the name of a new computational tool that mimics the processes of natural selection, producing proteins that can be used for a range of medicinal and household uses.

The enzymes in your laundry detergent, the insulin in your diabetes medication or the antibodies used in cancer therapy are currently made in the laboratory using a painstaking process called directed evolution.

Laboratory evolution mimics natural evolution by making mutations in naturally-sourced proteins and selecting the best mutants, to be mutated and selected again, in a time-intensive and laborious process that creates useful proteins.

Scientists at the ARC Centre of Excellence in Synthetic Biology have now discovered a way to perform the entire process of directed evolution using a computer. It can reduce the time required from many months or even years to just days.

The team was led by Professor Oliver Rackham, Curtin University, in collaboration with Professor Aleksandra Filipovska, the University of Western Australia, and is based at the Harry Perkins Institute of Medical Research in Perth, Western Australia.

To prove how useful this process could be they took a protein with no function at all and gave it the ability to bind DNA.

Proteins that bind DNA are currently revolutionizing the field of gene therapy where scientists are using them to reverse disease-causing mutations. So this could be of great use in the future. Reconstituting the entire process of directed evolution represents a radical advance for the field."

Professor Oliver Rackham, Curtin University

Source:
Journal reference:

Raven, S.A., et al. (2022) In silico evolution of nucleic acid-binding proteins from a nonfunctional scaffold. Nature Chemical Biology. doi.org/10.1038/s41589-022-00967-y.

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