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New Tool Brings Order to Single-Cell Data Chaos

A new methodology that allows for the categorization and organisation of single-cell data has been launched. It can be used to create a harmonized dataset for the study of human health and disease.

26 Dec 2023

Scientists Unravel the Mystery of Parkinson's Disease With 3D Protein Structures

Scientists at St. Jude Children's Research Hospital revealed the complex structure of two Parkinson's disease-related proteins, both of which are implicated in late-onset cases.

26 Dec 2023

The Adrenaline Puzzle Solved: Scientists Untangle Key Cell Receptor's Inner Workings

Through an international collaboration, scientists at St. Jude Children's Research Hospital leveraged data science, pharmacology and structural information to conduct an atomic-level investigation into how each amino acid in the receptor that binds adrenaline contributes to receptor activity in the presence of this natural ligand.

26 Dec 2023

Plants Use Stealth Molecular Weapon to Attack Cells of Invading Gray Mold

UC Riverside scientists have discovered a stealth molecular weapon that plants use to attack the cells of invading gray mold.

22 Dec 2023

Study Elucidates How Amino Acids Turn on Cell Growth Engine

Amino acids are the building blocks of life. We obtain them from the food we eat, and the body uses them to make proteins, which in turn are used for growth, development, and a multitude of other functions.

22 Dec 2023

Cracking the Code of the Cytoplasm: How Cells Organize Protein Production

Back in 2018, the lab of Christine Mayr, MD, PhD, at Memorial Sloan Kettering Cancer Center (MSK) introduced the world to a key cellular component that had been hiding in plain sight.

22 Dec 2023

Sticky Secrets Revealed: Epithelial Cells Stick and Signal for Perfect Tissues

Australian researchers have discovered a new way that epithelial cells, which form layers in organs like the skin and stomach, attach to one another, and how they perceive growth signals at these attachments, helping them form tissues of the right size and shape.

22 Dec 2023

Gut Mitochondria Hold the Key to Balanced Fat Metabolism

The maintenance of a balanced lipid homeostasis is critical for our health. While consumption of excessive amounts of fatty foods contributes to metabolic diseases such as obesity and atherosclerosis, fat is an indispensable component of our diet.

22 Dec 2023

New Technique Reveals Secrets of Protein Partnerships

Proteins are building blocks of our bodies, but they do not work solo. They form partners to facilitate in different biological processes that keep us going.

22 Dec 2023

NEMO Protein Promotes Degradation of Harmful Alpha-Synuclein Aggregates in Parkinson's Disease

Researchers have identified a mechanism that promotes the breakdown of harmful protein deposits. If it malfunctions, it can lead to Parkinson’s disease.

21 Dec 2023

How 3D DNA Architecture Shapes Cell Fate in Early Embryos

The intricate process of duplicating genetic information, referred to as DNA replication, lies at the heart of the transmission of life from one cell to another and from one organism to the next. This happens by not just simply copying the genetic information; a well-orchestrated sequence of molecular events has to happen at the right time.

21 Dec 2023

New Insights Into the Microbiome's Influence on Kidney Stone Risk

A new study from Lawson Health Research Institute and Western University published in the journal Microbiome has found changes in the microbiome in multiple locations in the body are linked to the formation of kidney stones.

21 Dec 2023

Intermittent Energy Restriction Diet Alters Brain-Gut-Microbiome Axis

Worldwide, more than one billion people are obese. Obesity is a risk factor for cardiovascular disease, diabetes, and some cancers.

21 Dec 2023

Microbial Sensor Unlocks Path to Personalized Blood Stem Cell Therapy

A microbial sensor that helps identify and fight bacterial infections also plays a key role in the development of blood stem cells, valuable new insight in the effort to create patient-derived blood stem cells that could eliminate the need for bone marrow transplants.

21 Dec 2023

Deciphering the Structure and Function of PLD3 in Cellular Waste Disposal

If we don't take out the trash regularly, our homes become unpleasant and even a danger to our health.

21 Dec 2023

Sirtuin 6 Boosts DNA Repair in Aging Cartilage Cells

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 23, entitled, "Sirtuin 6 activation rescues the age-related decline in DNA damage repair in primary human chondrocytes."

20 Dec 2023

Structural Insights Unmask Novel Adaptations and Functions of Human LINE-1 ORF2

Martin Taylor, MD, PhD, a physician investigator in the Department of Pathology at Massachusetts General Hospital and an instructor in Pathology at Harvard Medical School, is the lead corresponding author of a new study in Nature, Structural Analysis and Inhibition of Human LINE-1 ORF2 Protein Reveals Novel Adaptations and Functions.

20 Dec 2023

Researchers Discover Core Genes for Bacteria Colonizing Plants

Using a novel experimental approach, Max Planck researchers have discovered a core set of genes required by commensal bacteria to colonize their plant hosts.

20 Dec 2023

NUS Scientists Develop Novel Method to Identify and Sort Killer Immune Cells

Our body's immune system is a complex network of organs, cells, and proteins that work in synchrony to protect our bodies against infections caused by pathogens and fight against disease-causing changes in our body, such as the emergence of cancer cells.

20 Dec 2023

Light-Activated "Good Vibrations" can Destroy Cancer Cells

The Beach Boys' iconic hit single "Good Vibrations" takes on a whole new layer of meaning thanks to a recent discovery by Rice University scientists and collaborators, who have uncovered a way to destroy cancer cells by using the ability of some molecules to vibrate strongly when stimulated by light.

20 Dec 2023