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Water-Soluble Bacterial Enzyme Could Enable Rapid Screening of Potential Antibiotics

A bacterial enzyme called histidine kinase is a promising target for new classes of antibiotics. However, it has been difficult to develop drugs that target this enzyme, because it is a "hydrophobic" protein that loses its structure once removed from its normal location in the cell membrane.

11 Jun 2024

Lung Organoids Shed Light on Pseudomonas aeruginosa's Invasive Tactics

How do pathogens invade the lungs? Using human lung microtissues, a team at the Biozentrum of the University of Basel has uncovered the strategy used by a dangerous pathogen.

11 Jun 2024

CSHL Researchers Reveal New Protein Networks in RNA Splicing Regulation

Bodybuilders and cellular mechanisms agree generating protein is a heavy lift. To complete the task, cells rely on complexes called spliceosomes.

11 Jun 2024

Epitope Binning-Seq: Revolutionizing Antibody Drug Discovery

Monoclonal antibodies are powerful tools in medicine due to their remarkable ability to target specific sites on antigens (foreign invaders) called epitopes.

11 Jun 2024

Engineered Enzyme Boosts Gene Editing Efficiency for Potential Cystic Fibrosis Treatment

Researchers at the Broad Institute of MIT and Harvard have enhanced a gene-editing technology, enabling it to efficiently insert or substitute entire genes in the genome of human cells.

11 Jun 2024

Innovative Gene Editing Elevates Photosynthetic Efficiency in Food Crops

A team from the Innovative Genomics Institute at the University of California, Berkeley (UCB) has produced an increase in gene expression in a food crop by changing its upstream regulatory DNA.

10 Jun 2024

Study Highlights Key Protein-Lipid Interactions in Mitochondrial Energy Production

By studying mutations in yeast and human cells, Johns Hopkins Medicine scientists say they have found that biochemical bonds between fats and proteins in the mitochondrion, the cell's powerhouse, play a crucial role in how our cells produce energy.

10 Jun 2024

Dundee Scientists Reveal Inner Workings of PINK1 Molecular Switch in Parkinson's Disease

Scientists at the University of Dundee have uncovered the inner relay of a molecular switch that protects the brain against the development of Parkinson's disease.

10 Jun 2024

Study Finds Essential Role of Orco Protein in Ant Olfactory Neuron Survival and Social Interaction

While smell plays a considerable role in the social interactions of humans-;for instance, signaling fear or generating closeness-;for ants, it is vitally important.

10 Jun 2024

Study Unveils Broader Immune Response in EBV-MS Connection

Epstein-Barr virus (EBV) may have a greater effect on the development of multiple sclerosis (MS) than previously believed due to a higher level of cross-reactivity, which occurs when the immune system binds to the incorrect target.

10 Jun 2024

New research identifies and mitigates bias in CRISPR-Cas9 gene editing

A phenomics approach to study proximity bias and the unrelated chromosomal truncations.

10 Jun 2024

Unveiling the Chemical Secrets of Coral Reefs and Insights into Marine Health

What species exist on this coral reef, and how healthy are they?

7 Jun 2024

Unraveling the Mysteries of Killifish Embryonic Development

The annual killifish lives in regions with extreme drought. A research group at the University of Basel now reports in "Science" that the early embryogenesis of killifish diverges from that of other species.

7 Jun 2024

Study Reveals Diversity of DNA Transposons and Expands Genome Engineering Toolbox

In a study published in Cell, a research team led by Zhang Yong'e and WANG Haoyi from the Institute of Zoology of the Chinese Academy of Sciences has characterized the diversity of DNA transposons and expanded the genome engineering toolbox.

7 Jun 2024

Columbia Studies Uncover Misidentification of Gut Stem Cells

Two independent studies by Columbia scientists suggest that research into the gut's stem cells over the past 15 years has been marred by a case of mistaken identity: Scientists have been studying the wrong cell.

7 Jun 2024

Cellular Architecture Dictates T Cell Fate in Immune Response

From the outside, most T cells look the same: small and spherical. Now, a team of researchers led by Berend Snijder from the Institute of Molecular Systems Biology at ETH Zurich has taken a closer look inside these cells using advanced techniques.

7 Jun 2024

Novel Lipopeptide from Serratia marcescens Shows Promise Against Staphylococcus aureus Infections

A novel antibacterial lipopeptide produced by the bacterium Serratia marcescens has been shown to be highly effective in killing Staphylococcus aureus – one of the most important pathogens occurring in humans.

7 Jun 2024

Genetic Insights into Salt Gland Formation and Stress Responses in Sea Lavender

Basic helix–loop–helix (bHLH) transcription factors are essential for various plant processes, including growth, development, and stress responses.

7 Jun 2024

Determining Sex in Ants

Researchers at the universities of Mainz and Lausanne have identified a noncoding gene as the deciding factor in determining sex in Argentine ants.

From University of Mainz 7 Jun 2024

New mosTF Microscopy System Enhances Real-Time Brain Plasticity Research

The brain's ability to learn comes from "plasticity," in which neurons constantly edit and remodel the tiny connections called synapses that they make with other neurons to form circuits.

6 Jun 2024

Research News and Research

Water-Soluble Bacterial Enzyme Could Enable Rapid Screening of Potential Antibiotics

Lung Organoids Shed Light on Pseudomonas aeruginosa's Invasive Tactics

CSHL Researchers Reveal New Protein Networks in RNA Splicing Regulation

Epitope Binning-Seq: Revolutionizing Antibody Drug Discovery

Engineered Enzyme Boosts Gene Editing Efficiency for Potential Cystic Fibrosis Treatment

Innovative Gene Editing Elevates Photosynthetic Efficiency in Food Crops

Study Highlights Key Protein-Lipid Interactions in Mitochondrial Energy Production

Dundee Scientists Reveal Inner Workings of PINK1 Molecular Switch in Parkinson's Disease

Study Finds Essential Role of Orco Protein in Ant Olfactory Neuron Survival and Social Interaction

Study Unveils Broader Immune Response in EBV-MS Connection

New research identifies and mitigates bias in CRISPR-Cas9 gene editing

Unveiling the Chemical Secrets of Coral Reefs and Insights into Marine Health

Unraveling the Mysteries of Killifish Embryonic Development

Study Reveals Diversity of DNA Transposons and Expands Genome Engineering Toolbox

Columbia Studies Uncover Misidentification of Gut Stem Cells

Cellular Architecture Dictates T Cell Fate in Immune Response

Novel Lipopeptide from Serratia marcescens Shows Promise Against Staphylococcus aureus Infections

Genetic Insights into Salt Gland Formation and Stress Responses in Sea Lavender

Determining Sex in Ants

New mosTF Microscopy System Enhances Real-Time Brain Plasticity Research

Industry Focus eBook - Analytical Chemistry (2nd Edition) eBook

How a Single List Is Changing Visibility for Women in Science

How Avatar Medical's 3D Technology Is Transforming How We Visualize the Human Body

Driving Support for Pharmaceutical Testing Through Continuous Innovation

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