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New study on genotype-phenotype associations sheds light on human complex traits, diseases

A new study analyzing the association between an individual's genetics (genotype) and their observable characteristics resulting from the interaction of genetics and the environment (phenotype), contributes new knowledge to the understanding of human complex traits and diseases.

2 Jun 2021

Scientists discover the central role of LRRC8A gene in cellular ability to survive osmotic shock

Cells have to constantly adapt to their surroundings in order to survive. A sudden increase in the environmental levels of an osmolyte, such as salt, causes cells to lose water and shrink. In a matter of seconds, they activate a mechanism that allows them to recover their initial water volume and avoid dying.

2 Jun 2021

Diet plays a crucial role in liver disease outcome, mouse model shows

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. NAFLD patients are at higher risk of developing Non-alcoholic steatohepatitis (NASH), which causes severe and chronic liver inflammation, fibrosis and liver damage.

2 Jun 2021

Study discovers novel function for metabolic enzyme medium-chain acyl-CoA dehydrogenase

Scientists have come up with an innovative function for the metabolic enzyme medium-chain acyl-CoA dehydrogenase (MCAD) in glioblastoma (GBM).

1 Jun 2021

Genetic differences within microalgal symbionts relate to the coral species they inhabit

The microscopic algae that live inside and provide nutrients to their reef-building coral hosts may be evolving in tandem with the corals they inhabit, so each partner is fine-tuned to meet one another's needs.

From Penn State University 1 Jun 2021

AMSBIO's custom lentivectors enable visualization of cell nuclei and F-actin cytoskeleton in organoids

AMSBIO have supplied custom lentivectors to Francesco Pampaloni and his team at the Buchmann Institute for Molecular Life Sciences in Frankfurt, Germany allowing them to visualize cell nuclei and F-actin cytoskeleton in their organoids.

From AMS Biotechnology 1 Jun 2021

Scientists describe pathway that leads to accelerated flowering of plants in low-nitrogen soils

Scientists from Japan, Europe and the USA have described a pathway leading to the accelerated flowering of plants in low-nitrogen soils. These findings could eventually lead to increases in agricultural production.

31 May 2021

Genetic editing tools stop the spread of Culex mosquitoes

Since the onset of the CRISPR genetic editing revolution, scientists have been working to leverage the technology in the development of gene drives that target pathogen-spreading mosquitoes such as Anopheles and Aedes species, which spread malaria, dengue and other life-threatening diseases.

From UC San Diego 31 May 2021

More informed choices of contraceptives can prevent breast cancer

Hormonal contraceptives, e.g. the pill, the patch, and the vaginal ring, contain synthetic hormones that prevent pregnancy by either stopping ovulation, changing the cervical mucus to stop sperm from passing through the cervix and finding an egg, or changing the womb's lining to prevent a fertilized egg from being implanted in it.

31 May 2021

Novel drug is highly effective in preventing severe COVID-19 in mice

The drug diABZI -- which activates the body's innate immune response -- was highly effective in preventing severe COVID-19 in mice that were infected with SARS-CoV-2,

31 May 2021

Scientists identify mechanism by which head and neck cancer cells subvert adjacent normal tissue

Up to half of patients with head and neck squamous cell carcinoma will experience tumor recurrence or new tumors--tumors that often spread and are difficult to treat.

28 May 2021

Non-specific lipid transfer proteins help improve wheat tolerance

Fusarium Head Blight (FHB), often called scab, is a serious disease of small grain cereals like barley and wheat that affects farmers worldwide.

27 May 2021

Researchers discover new genes and functionalities in bovine genome

Modern genetic research often works with what are known as reference genomes. Such a genome comprises data from DNA sequences that scientists have assembled as a representative example of the genetic makeup of a species.

27 May 2021

Genomic study can reveal adaptive mechanisms of life under future ocean acidification

Human-driven global change is challenging the scientific community to understand how marine species might adapt to predicted environmental conditions in the near-future (e.g. hypoxia, ocean warming, and ocean acidification).

27 May 2021

New software tool detects, evaluates, and quantifies off-target editing activity

CRISPR technology enables researchers to edit genomes by modifying DNA sequences and hence gene function.

27 May 2021

Genetic and molecular mechanisms make chemotherapy drug work for some cancer patients

The chemotherapy drug decitabine is commonly used to treat patients with blood cancers, but its response rate is somewhat low. Researchers have now identified why this is the case, opening the door to more personalized cancer therapies for those with these types of cancers, and perhaps further afield.

25 May 2021

Study could help develop peptide siRNA carrier for human oral cancer

MUSC Hollings Cancer Center researchers are exploring the use of peptide carriers for the delivery of small RNA drugs as a novel treatment for cancer. The team's recent work, published online March 19 in the Molecular Therapy - Nucleic Acids journal, lays the foundation for developing a clinically relevant peptide carrier RNAi-based drug treatment strategy for human oral cancer.

25 May 2021

Genes News and Research

New study on genotype-phenotype associations sheds light on human complex traits, diseases

Scientists discover the central role of LRRC8A gene in cellular ability to survive osmotic shock

Diet plays a crucial role in liver disease outcome, mouse model shows

Study discovers novel function for metabolic enzyme medium-chain acyl-CoA dehydrogenase

Genetic differences within microalgal symbionts relate to the coral species they inhabit

AMSBIO's custom lentivectors enable visualization of cell nuclei and F-actin cytoskeleton in organoids

Scientists describe pathway that leads to accelerated flowering of plants in low-nitrogen soils

Genetic editing tools stop the spread of Culex mosquitoes

More informed choices of contraceptives can prevent breast cancer

Novel drug is highly effective in preventing severe COVID-19 in mice

Scientists identify mechanism by which head and neck cancer cells subvert adjacent normal tissue

Non-specific lipid transfer proteins help improve wheat tolerance

Researchers discover new genes and functionalities in bovine genome

Genomic study can reveal adaptive mechanisms of life under future ocean acidification

New software tool detects, evaluates, and quantifies off-target editing activity

Genetic and molecular mechanisms make chemotherapy drug work for some cancer patients

Study could help develop peptide siRNA carrier for human oral cancer

Exposure to chemicals in plastic during the fetal stage is linked with a lower IQ

Study shows how mitochondrial function impacts schizophrenia in patients with genetic disorder

Study identifies predictive causal role for specific cell types in type 1 diabetes

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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