Genes News and Research

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Breast cancer-on-a-chip for rapid screening of immunotherapeutic drugs

There are many mechanisms by which the body responds to foreign invaders. One of these involves the T-cells of the immune system, which have a number of different proteins on their surface called "checkpoint proteins."

3 Feb 2021

Noncoding RNA plays key role in sepsis, regulates inflammatory gene expression

Sepsis can result when the body’s immune response to a specific infection gets out of control.

From University of California Santa Cruz 2 Feb 2021

Severe genetic immunodeficiency reversed by a rare DNA change

Researchers have revealed how a rare DNA change rebalanced the immune system of patients with a life-threatening genetic immunodeficiency.

2 Feb 2021

Scientists identify specific genes associated with post-traumatic stress disorder

A research team has found 18 specific, fixed positions on chromosomes (called loci) that seem to be linked to post-traumatic stress disorder (PTSD).

29 Jan 2021

Scientists discover the origin of rare genetic syndrome

Improvements in DNA sequencing have revealed a rare syndrome triggered by changes in the SATB1gene.

29 Jan 2021

Ocean acidification could be affecting lobsters on a molecular scale

The American lobster, which supports the most valuable fishery in North America, maybe more susceptible to the effects of climate change than previously thought, according to a new study published in Ecology and Evolution.

29 Jan 2021

3D genome study reveals molecular regulatory mechanisms of human brain evolution

A team led by Prof. SU Bing from the Kunming Institute of Zoology (KIZ) of the Chinese Academy of Sciences (CAS), Prof. LI Cheng from Peking University, and Prof. ZHANG Shihua from the Academy of Mathematics and Systems Science of CAS has reported the highest resolution by far of the 3D genome of the primate brain, and demonstrated the molecular regulatory mechanisms of human brain evolution through cross-species multi-omics analysis and experimental validation. The study was published in Cell.

29 Jan 2021

Targeting glycoprotein could improve response to immune checkpoint therapy

It was an unexpected discovery that started with an analysis of more than 1,000 genes. The question: why game-changing cancer immunotherapy treatments work for only a fraction of patients.

29 Jan 2021

Study shows TALEN is five times more efficient than CRISPR-Cas9 tool

Using single-molecule imaging, scientists have compared the CRISPR-Cas9 and TALEN genome editing tools.

28 Jan 2021

Researchers produce a high-quality reference sequence of the switchgrass genome

Gardeners and farmers around the country recognize that crop varieties grow best in certain regions. Most plant species have adapted to their local environments; for example, crop and ornamental seeds sold for the upper Midwest are often very different than those bred for Texas.

28 Jan 2021

LEAFY protein licenses cell reprogramming to floral fate

Cells don't express all the genes they contain all the time. The portion of our genome that encodes eye color, for example, doesn't need to be turned on in liver cells. In plants, genes encoding the structure of a flower can be turned off in cells that will form a leaf.

28 Jan 2021

New computational method simplifies the analysis of gene-environmental interactions

Scientists from Weill Cornell Medicine and the Ithaca campus at Cornell University have designed a novel computational technique for analyzing environmental and genetic interactions and how they affect disease risk.

28 Jan 2021

Researchers publish a complex genome analysis of switchgrass

Biologists believe they are one step closer to a long-held goal of making a cheap, widely available plant a source for energy and fuel, meaning one of the next big weapons in the battle against climate change may be able to trace its roots to the side of a Texas highway.

28 Jan 2021

Two enzymes drive pre-cancer stem cells into malignancy

Since stem cells can continually self-regenerate, making more stem cells, and differentiate into many different specialized cell types, they play an important role in our development and health.

From UC San Diego 27 Jan 2021

Study shows why obese mothers tend to have children susceptible to metabolic diseases

A Brazilian study published in the journal Molecular Human Reproduction helps understand why obese mothers tend to have children with a propensity to develop the metabolic disease during their lifetime, as suggested by previous research.

27 Jan 2021

New search engine helps compare samples in different microbiomes

Metagenomics refers to the study of genetic material from an environmental specimen. This field is now progressing as organisms evolve or are identified worldwide.

26 Jan 2021

New variant of CRISPR-Cas9 tool expands genomic editing in plants

For the first time, Yiping Qi has represented the College of Agriculture & Natural Resources on the Web of Science 2020 list of Highly Cited Researchers.

26 Jan 2021

Pioneer transcription factors help turn on key genes that give cells unique properties

Biologists have long wondered how complex organisms contain a variety of dramatically different types of cells with specialized functions, even though all of those cells are genetically identical.

25 Jan 2021

Study reveals complete genome of major parasitic flowering plant

On January 22 in Current Biology, a team of Harvard-led researchers presented the most complete genome yet assembled of one of the major Rafflesiaceae lineages, Sapria himalayana.

25 Jan 2021

New protocol identifies mismatch repair deficiency

Researchers have developed a new integrated genetic/epigenetic DNA-sequencing protocol known as MultiMMR that can identify the presence and cause of mismatch repair (MMR) deficiency in a single test from a small sample of DNA in the colon, endometrial, and other cancers.

22 Jan 2021