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More Genes Changed By Early Life Stress Than Head Injury

Researchers recently discovered a phenomenon as they delved into the investigation of whether early-life stress exacerbates the impact of a childhood head injury on health and behavior in later years.

16 Nov 2023

Rare Genetic Variant Found to Protect Against Alzheimer's Disease

Researchers at Gladstone Institutes have discovered that a rare genetic variant known as the "Christchurch mutation" can block detrimental effects of apolipoprotein E4, the best-established risk factor for the most common form of Alzheimer's disease.

14 Nov 2023

New Drug-Like Molecule Enhances Mitophagy, Protects Against Neurodegeneration

Having healthy mitochondria, the organelles that produce energy in all our cells, usually portends a long healthy life whether in humans or in C. elegans, a tiny, short-lived nematode worm often used to study the aging process.

14 Nov 2023

Role of Inhibitory Interneurons in Memory Expression

Memory, a crucial aspect of human survival, is intricately connected to how humans encode, retrieve, and react to external stimuli.

9 Nov 2023

Distinctive Taste Receptors Between a Moth’s Larval and Adult Stages

New research reveals that the cotton bollworm (Helicoverpa armigera) employs distinct sugar-sensing mechanisms in its larval and adult stages to fulfill its dietary preferences.

8 Nov 2023

Novel Gene Therapy Targets Core Motor Symptoms of Parkinson’s Disease

A team of researchers from the Shenzhen Institute of Advanced Technology (SIAT) at the Chinese Academy of Sciences (CAS) and their collaborators have devised a gene therapy approach aimed at selectively manipulating the affected circuitry in Parkinson’s disease.

6 Nov 2023

Unlocking the Secrets of Memory: Key Protein Regulates Hippocampal Plasticity

Mount Sinai researchers have shed valuable light on the mechanism of a key protein that regulates the plasticity and function of the hippocampus, a key brain region involved in memory and learning, and that decreases with age in mice.

3 Nov 2023

Study Identifies Significant Changes in Peptides During Pyroglutamination

Peptides are biomolecules formed when two or more amino acids that perform key functions in the human organism, such as hormones, neurotransmitters, painkillers and antibiotics, bind together. For this reason, they are much studied and used by the pharmaceutical industry, for example.

2 Nov 2023

Scientists Unlock the Structure of Vesicular Monoamine Transporter 2

Neurons talk to each other using chemical signals called neurotransmitters. Scientists at St. Jude Children's Research Hospital have drawn on structural biology expertise to determine structures of vesicular monoamine transporter 2 (VMAT2), a key component of neuronal communication.

2 Nov 2023

DNA’s Role in Glioblastoma: Insights from Umeå University’s Research

A groundbreaking research conducted at Umeå University in Sweden has revealed that the three-dimensional arrangement of DNA can impact the development of aggressive brain cancer, glioblastoma.

1 Nov 2023

Kingfisher Genes Reveal Secrets of How They Dive Without Sustaining Brain Damage

If you've ever belly-flopped into a pool, then you know: water can be surprisingly hard if you hit it at the wrong angle. But many species of kingfishers dive headfirst into water to catch their fishy prey.

24 Oct 2023

New Insight Into How Cancer Cells Function in Softer Tissue Environments

A collaborative research team from the University of Turku and Turku Bioscience Centre, in conjunction with Misvik Biology Ltd in Finland, has introduced a novel technique for investigating the behavior of cancer cells in both softer and stiffer tissue environments.

19 Oct 2023

Developing Regenerative Therapies to Treat Neurological Conditions

The primary cells that make up our brain and spinal cord, called neurons, are among the slowest to heal after injury, and many neurons never fully recover. Although research into neural regeneration has advanced, it is still unclear why certain neurons recover while others do not.

17 Oct 2023

Breakthrough Research Discovers How the Body Controls Itch

It can be a relief to scratch the occasional itch, but when itch gets out of control, it can become a serious health problem. How does the body know when to stop?

16 Oct 2023

Fruit Fly Model Provides Insights into Pathogenesis of New Genetic Disorder

Research conducted in the laboratory of Dr Hugo J. Bellen, a Distinguished Service Professor at Baylor College of Medicine and a principal investigator at the Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas Children's Hospital, has identified a novel disorder linked to gain-of-function variants in the DOT1L gene.

16 Oct 2023

New Atlases Reveal Unprecedented Detail of the Human Brain

In two concurrent projects, scientists at the Karolinska Institutet have played a significant role in producing the most extensive atlases of human brain cells to date.

13 Oct 2023

Increased Pain Sensitivity and Neanderthal Gene Variants

According to a recent study co-led by UCL researchers, those who contain three gene variations acquired from Neanderthals are more susceptible to specific types of pain.

11 Oct 2023

Study Links Autism Gene to Broad Spectrum of Molecular and Cellular Defects

Researchers have used CRISPR gene editing, stem cells and human neurons to study the impact of a gene that is commonly mutated in autism.

6 Oct 2023

Scientists Gain Insights into Biophysical Properties of Neurons with New Workflow

Biophysically detailed neuronal models provide a unique window into the workings of individual neurons.

5 Oct 2023

New Synthetic Biology Approach Offers Promise for Treating Neurodegenerative Diseases

Researchers at the University of Cologne's CECAD Cluster of Excellence for Aging Research and the CEPLAS Cluster of Excellence for Plant Sciences have found a promising synthetic plant biology approach for the development of a therapy to treat human neurodegenerative diseases, especially Huntington's disease.

3 Oct 2023