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PPP2R1A Gene Mutations Improve ATR Inhibitor Drug Effectiveness in Ovarian Clear Cell Cancers

A study in Oncogene shows that PPP2R1A mutations increase sensitivity to ATR inhibitors in ARID1A-mutant ovarian clear cell carcinoma, suggesting a potential biomarker for improved treatment strategies.

5 Jun 2025

Canine DNA Reveals New Genes Linked to Gastric Cancer In Humans

Dogs share our homes, our habits and sometimes, our diseases. Gastric cancer is rare in dogs, but when it does strike, it closely resembles gastric cancer in humans: subtle clinical signs, comparable tumor subtypes, late-stage diagnosis and poor outcomes.

3 Jun 2025

Evolution of Cancer Genomes During Metastasis

Research on cancer metastasis uncovers genetic complexities, showing that copy-number alterations play a key role in tumor evolution and treatment resistance.

3 Jun 2025

Exon-Specific Analysis Uncovers Novel Insights into Psychiatric Disease

This research highlights the role of exons in mental illnesses, offering new perspectives on genetic factors that influence psychiatric disorder development.

3 Jun 2025

New Genome Assembly Sheds Light on Tropical Vine's Invasive Success

Merremia boisiana, a member of the Convolvulaceae family, a fast-growing vine native to tropical rainforests and known for its vibrant golden flowers and astonishing climbing ability, grows at speeds exceeding 12 cm per day, often overwhelming native vegetation and disrupting forest ecosystems.

2 Jun 2025

Three-Dimensionally Reconstructed Kidney Glomerulus Simulates Structural and Functional Characteristics In Vitro

A 3D engineered kidney glomerulus model replicates structural and mechanical features of the glomerular filtration barrier, enabling the study of podocyte-related diseases and drug screening with improved physiological relevance.

2 Jun 2025

How Domestication Changed Cat Genes and Behavior

Whether one is fortunate enough to have a cat friend or must enjoy the experience vicariously through cat videos, Felis catus is a familiar and reassuring presence in our daily lives.

30 May 2025

Study Identifies SMARCB1 and MEOX2 Genes as Growth Regulators of Lung Cancers

A Cancer Gene Therapy study reveals that MEOX2 promotes lung cancer progression while SMARCB1 acts as a tumor suppressor, influencing EGFR expression and response to tyrosine kinase inhibitors.

30 May 2025

Herpes Virus Protein Enhances T-Cell Survival for Cancer Therapy

Recent studies reveal the herpes virus may enhance cancer treatment by activating T cell pathways, improving immunotherapy effectiveness against tumors.

29 May 2025

Unraveling the Mysteries of the Barr Body and Aging

Aging in female mice shows increased gene activity on the second X chromosome, offering insights into cardiovascular disease and neurodegenerative disorders.

28 May 2025

Study Reveals How APOE Isoforms Impact Brain Microglia

A study reveals how APOE isoforms influence microglial activity in Alzheimer's, highlighting the need for targeted interventions based on genetic risk factors.

28 May 2025

Cobraa: A Coalescence-Based Model Infers a Structured Ancestry Shared by Modern-Day Humans

The Cobraa model offers insights into human evolution, detailing ancestral population dynamics and genetic admixture events over the last 1.5 million years.

28 May 2025

Epigenome Editing: Enhancing Endonuclease Protein Design for In Vivo Applications

Researchers have engineered a compact, high-specificity IscB variant, NovaIscB, for safe, persistent in vivo epigenome editing using AAV delivery, offering a powerful tool for gene regulation without DNA breaks.

28 May 2025

Study Challenges Longstanding Mitochondrial Theory of Aging

The human genome is broadly classified into the genome residing in the cell nucleus (nuclear DNA) and the genome residing in the mitochondria (mitochondrial DNA: mtDNA). Mitochondria are cell organelles that produce energy essential for life activities through oxidative phosphorylation (mitochondrial respiration), and mtDNA encodes a set of genes required for mitochondrial respiration.

27 May 2025

Mutation Profiling Reveals Therapeutic Targets in Lung Squamous Cell Carcinoma

Lung Squamous cell carcinoma (LSCC) represents the second most common non-small cell lung cancer. Although studies identified adenocarcinoma-like driver mutations in LSCC using next-generation sequencing (NGS), the disease is challenging to treat due to the limited number of detectable mutations for targeted drug therapy.

27 May 2025

RNA Editing and Transcriptional Switching Shape Fungal Antiviral Response

The expression of symptoms of viral infections is a byproduct of complex virus-host molecular pathways. These remain largely unknown, especially in the case of fungus-virus pathogen systems.

24 May 2025

New Genomic Score Predicts Risk of Progression in Multiple Myeloma

A new risk assessment score developed by researchers at Dana-Farber Cancer Institute and the Broad Institute of MIT and Harvard reveals how multiple myeloma, a form of blood cancer, begins and progresses from precancerous to malignant states by tracing DNA mutations.

24 May 2025

Gene Loss and Gain Shaped the Evolution of Relapsing Fever Bacteria

Researchers at the Francis Crick Institute and UCL have analyzed ancient DNA from Borrelia recurrentis, a type of bacteria that causes relapsing fever, pinpointing when it evolved to spread through lice rather than ticks, and how it gained and lost genes in the process.

24 May 2025

Study Reveals How Introns Multiply and Move Across Genomes

DNA is the genetic code that provides the biological instructions for every living species, but not every bit of DNA helps the species survive. Some pieces of DNA are more like parasites, along for the ride and their own survival.

24 May 2025

Uncovering How Cholera Evaded Phages For Epidemic Success

Cholera bacteria engage in microscopic battles with phages, influencing pandemic dynamics and highlighting the role of viral defenses in outbreak management.

23 May 2025