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The Link Between Climate Change and Drug-Resistant Fungal Infections

In a recent study on fungal diseases in Chinese hospitals, researchers discovered that two individuals were infected by a previously undocumented fungus affecting human health.

20 Jun 2024

Breakthrough Imaging Reveals the Dynamics of the Brain's Fast-Acting Kainate Receptor

New groundbreaking images of one of the brain's fastest-acting proteins are providing critical clues that may lead to the development of targeted therapies to treat epilepsy and other brain disorders.

18 Jun 2024

Nutrient Nanomedicine Shows Promise Against Skin Cancer

An international research team has discovered a new way to effectively treat cancer, by using nutrients to reactivate suppressed metabolic pathways in cancer cells.

18 Jun 2024

New Clinical Trial Offers Path to Sickle Cell Cure

The most recent results from a clinical trial were given by researchers in an effort to find a cure for sickle cell disease, a painful genetic blood illness that has few available treatments.

17 Jun 2024

Johns Hopkins Scientists Engineer Synthetic Cells to Mimic Symmetry Breaking

In a feat aimed at understanding how cells move and creating new ways to shuttle drugs through the body, scientists at Johns Hopkins Medicine say they have built a minimal synthetic cell that follows an external chemical cue and demonstrates a governing principle of biology called "symmetry breaking."

14 Jun 2024

Super-Cooled Brain Cell Molecules Shed Light on Epilepsy Drug Action

By super cooling a molecule on the surface of brain cells down to about minus 180 degrees Celsius -; nearly twice as cold as the coldest places in Antarctica -; scientists at Johns Hopkins Medicine say they have determined how a widely-used epilepsy drug works to dampen the excitability of brain cells and help to control, although not cure, seizures.

11 Jun 2024

Discovery Speeds Up Cyclic Peptide Production for Antibiotic Development

A discovery made by scientists at King's College London could speed up efforts to produce new antibiotics in the fight against antimicrobial resistance.

11 Jun 2024

Water-Soluble Bacterial Enzyme Could Enable Rapid Screening of Potential Antibiotics

A bacterial enzyme called histidine kinase is a promising target for new classes of antibiotics. However, it has been difficult to develop drugs that target this enzyme, because it is a "hydrophobic" protein that loses its structure once removed from its normal location in the cell membrane.

11 Jun 2024

CARA Benchmark Set to Revolutionize Data-Driven Drug Discovery Methods

A compound activity prediction benchmark they curated for real-world, practical applications called Compound Activity benchmark for Real-world Applications (CARA).

11 Jun 2024

Dundee Scientists Reveal Inner Workings of PINK1 Molecular Switch in Parkinson's Disease

Scientists at the University of Dundee have uncovered the inner relay of a molecular switch that protects the brain against the development of Parkinson's disease.

10 Jun 2024

Peptidomimetics Unlock New Potential in Drug Discovery

Collaborating with the Universities of Bristol and Leeds, researchers at the University of Birmingham have effectively demonstrated a method for modifying peptides to transform them into potentially useful tools for drug discovery and disease diagnosis

10 Jun 2024

Genetic Clues Unveil New Insights into Restless Leg Syndrome

Scientists have discovered genetic clues to the cause of restless leg syndrome, a condition common among older adults.

6 Jun 2024

Coordinated Proteins Aid the Immune System in Detecting and Destroying Threats

Bacteria, parasites, and viruses—the immune system tackles them all. Cells known as macrophages are at the forefront of the human immune response, recognizing intruders and controlling how the entire immune system responds.

6 Jun 2024

UC San Diego Researchers Find Cause of Cellular 'Short-Circuit'

A group of researchers at University of California San Diego has identified the cause of a "short-circuit" in cellular pathways, a discovery that sheds new light on the genesis of a number of human diseases.

5 Jun 2024

Impact of Rare Disease Mutation Could Extend to More Prevalent Conditions

REX1 is a gene that is meant to direct the maintenance of the entire body’s DNA, but new research shows that when people are born with mutated TREX1, the DNA suffers catastrophic damage over time, resulting in a deadly rare disease known as retinal vasculopathy with cerebral leukoencephalopathy (RVCL).

5 Jun 2024

New Microscopy Reveals Secrets of SARS-CoV-2 Replication

Recent research published in Nature Communications by a Stanford University team may provide more accuracy in drug development by examining at the nanoscale how the SARS-CoV-2 virus replicates in cells.

4 Jun 2024

Exploring Hepatic and Serum Proteomic Signatures in Werner Syndrome Mice

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 10, entitled, "Integrated liver and serum proteomics uncover sexual dimorphism and alteration of several immune response proteins in an aging Werner syndrome mouse model."

4 Jun 2024