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Tough protein connects directly with neurons to cause damaging inflammatory reaction in the brain

Neuroinflammatory diseases, including Alzheimer's disease and traumatic brain injury, have been linked to deposits of a tough protein known as fibrin, derived from the blood clotting factor fibrinogen.

9 Nov 2021

New technique to design enzyme stereoselectivity and substrate acceptance

Professor Zhoutong Sun headed a research team to develop Proline Induced Loop Engineering Test (PiLoT) method.

8 Nov 2021

Researchers employ hepatic organoids for disease modeling

Associate Professor Tamer Önder created and analyzed the hepatic organoid culture system utilizing human induced pluripotent stem cell as an intermediate.

8 Nov 2021

Study employs engineered base editors for controllable genome editing

According to a recent study, targeted mutations to the genome can be instituted by splitting specific mutator enzymes and later inducing them to reconstitute.

1 Nov 2021

Researchers develop new approach to selectively turn on gene therapies in target cells

Researchers at MIT and Harvard University have designed a way to selectively turn on gene therapies in target cells, including human cells. Their technology can detect specific messenger RNA sequences in cells, and that detection then triggers production of a specific protein from a transgene, or artificial gene.

From Massachusetts Institute of Technology (MIT) 29 Oct 2021

Low dose of pollutants in food leads to high activation of antibodies that cause allergic response

Exposure to the heavy metal cadmium is known to irritate the stomach and lungs or cause kidney disease, but new research links another health issue to inadvertently ingesting low doses of the pollutant: high activation of the antibodies that cause an allergic response.

27 Oct 2021

Novel platform enables sequence-unconstrained traceless protein synthesis

According to recent research published a multi-enzyme platform was created for sequence-unconstrained traceless protein synthesis and modification.

26 Oct 2021

Study pinpoints the mutational hotspots in DNA

Recent research at the University of Bath reveals that tangles in unwound DNA can develop mutational hotspots in the genomes of bacteria.

From University of Bath 21 Oct 2021

Researchers map proteo-genomic connections between different human diseases

Hundreds of connections between different human diseases have been uncovered through their shared origin in our genome by an international research team led by scientists from the Medical Research Council (MRC) Epidemiology Unit at the University of Cambridge, challenging the categorisation of diseases by organ, symptoms, or clinical speciality.

18 Oct 2021

Pioneering gene therapy has long-lasting effects on children with deadly immune disorder

Over a decade ago, UCLA physician-scientists began using a pioneering gene therapy they developed to treat children born with a rare and deadly immune system disorder. They now report that the effects of the therapy appear to be long-lasting, with 90% of patients who received the treatment eight to 11 years ago still disease-free.

18 Oct 2021

Researchers improve understanding of molecular mechanisms underlying stomach’s acid pump

Nagoya University researchers and colleagues have improved understanding of the molecular mechanisms of a key protein that makes the stomach acidic. Their findings, published in the journal Nature Communications, could lead to better drugs for stomach ulcers and shed light on the functions of similar proteins across the human body.

15 Oct 2021

Study provides insights on mucin degradation mechanisms by a group of gut bacteria

Recent research identified that a single sulfatase adds to the degradation of mucus that safeguards the intestinal lining.

13 Oct 2021

New technology efficiently delivers immune checkpoint inhibitors for treating brain tumors

Multi-institutional researchers have succeeded in efficiently delivering an immune checkpoint inhibitor (ICI) into the mouse brain, confirming its high efficacy and specificity in treating orthotopically transplanted mice with glioblastoma (GBM). The research was published in Nature Biomedical Engineering.

12 Oct 2021

Study provides novel insights into the breakdown of carminic acid

Carminic acid (a natural red dye extracted from insects) is extensively used in the cosmetic, pharmaceutical, and food industries globally

7 Oct 2021

Active genes do not form clusters and share resources during early development in fruit flies

Active genes do not form clusters and share resources during early development in the fruit fly, according to a new study by New York University and Princeton researchers published in the journal Current Biology.

6 Oct 2021

High levels of polyunsaturated fatty acids in liver cells linked to hepatitis C virus resistance

Hepatitis C virus thrives in humans for years, damaging the liver by causing chronic inflammation, eventually resulting in cirrhosis and liver cancer.

4 Oct 2021

Study finds a correlation between zika-induced neurological complications and Gas6 protein

An article by Brazilian researchers published in the journal Brain, Behavior, and Immunity elucidates one of the mechanisms whereby zika virus causes neurological complications in adult patients and microcephaly in fetuses. The discovery paves the way for future research to develop drugs that combat the virus.

4 Oct 2021

Study pinpoints means to restore the efficacy of drugs for acute myeloid leukemia

Researchers elucidate why certain drugs, in clinical trials, for treating a kind of acute myeloid leukemia often fail and revealed a means to restore their efficacy.

1 Oct 2021

Study develops a highly efficient expression system for high protease yield

Proteases, one of the most inventive products, are utilized to enhance the efficacy of feed additives.

28 Sep 2021

Exploring cell and gene based therapies for Parkinson’s disease

After several decades of pre-clinical development, cell- and gene-based therapies for Parkinson's disease (PD) are now actively being explored. In this special supplement to the Journal of Parkinson's Disease on "Repairing the Parkinsonian Brain," experts highlight some of the current strategies being pursued to restore lost function and replace what is lost in the PD brain, with special emphasis on the challenges associated with translating advanced therapeutic approaches into pioneering clinical trials.

24 Sep 2021