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Rare ITSN1 Gene Variants Found to Significantly Elevate Parkinson's Risk

A new study published in Cell Reports reveals a breakthrough discovery linking genetic variants in the gene ITSN1 to a significantly elevated risk of Parkinson's disease, a neurodegenerative condition that affects nearly 2% of adults older than 65 years.

10 Mar 2025

Circular RNA's Transformative Role in Tumor Biology and Treatment

A new review article highlights the transformative role of circular RNA (circRNA) in cancer, revealing its potential as both a key player in tumor biology and a promising avenue for future therapies.

10 Mar 2025

Investigating Ubiquitination's Role in Cancer Stem Cell Regulation

This review highlights the critical role of ubiquitination in governing the functionality of cancer stem cells (CSCs), shedding light on potential therapeutic targets for combating tumor progression, recurrence, and drug resistance.

10 Mar 2025

Low-Cost, Flexible Protein Detection Platform for Global Health

Chemical and biomolecular engineers at Georgia Tech have created a plug-and-play platform for the detection of disease protein biomarkers that is straightforward, adaptable, and user-friendly, eliminating the need for expensive laboratory equipment.

10 Mar 2025

Novel Expansion Microscopy Technique for Detailed Plant Biomolecule Mapping

The approach to studying plant cells is evolving quite literally due to new research led by Kevin Cox, an Assistant Professor of Biology in Arts & Sciences at Washington University in St. Louis and an Assistant Member of the Donald Danforth Plant Science Center.

10 Mar 2025

Cellular Changes as Lung Damage Worsens During COVID-19 Revealed

Changes in the cellular response during lung damage caused by SARS-CoV-2 – the virus behind COVID-19 – have been uncovered.

10 Mar 2025

Protective ‘Slime’ In The Brain May Help Prevent Aging And Neurodegeneration

The study shows that boosting mucin-type O-glycosylation in aged mice reinforces the blood-brain barrier and improves memory, paving the way for new treatments.

10 Mar 2025

Genomics can Transform Care for Children with Rare Diseases

A simple genomics blood test could improve treatment and care for childhood epilepsy, but more investment is needed to make access fair and securely join up the data, finds a new study involving researchers at University College London (UCL) and Great Ormond Street Hospital for Children (GOSH).

8 Mar 2025

Study Shows How Transposons Exploit Telomeres in Bacteria

Transposons, or "jumping genes" – DNA segments that can move from one part of the genome to another – are key to bacterial evolution and the development of antibiotic resistance.

8 Mar 2025

DENND1B Gene Linked to Obesity in Dogs and Humans

Dogs are a compelling model of human obesity, in part because they develop obesity due to similar environmental influences as people.

8 Mar 2025

New Brain-Mapping Technique Pinpoints Cell Types Linked to Alzheimer's Progression

Researchers from The University of Texas at Arlington and the University of California–San Francisco have employed a novel brain-mapping technique to pinpoint memory-related brain cells that are susceptible to protein accumulation, a significant contributor to the onset of Alzheimer’s disease, an irreversible and progressive neurological disorder that gradually impairs memory and cognitive abilities.

7 Mar 2025

Novel Enzyme for Synthesizing β-1,2-Galactooligosaccharides

Carbohydrate chains, also known as glycans, are intricate sugar-like molecules that are crucial for various biological functions and structures within human bodies.

7 Mar 2025

New Genetic Discovery Could Lead to Larger Tomatoes and Eggplants

Bigger, tastier tomatoes and eggplants could soon grace our dinner plates thanks to Johns Hopkins scientists who have discovered genes that control how large the fruits will grow.

6 Mar 2025

Cryo-ET Reveals Retrotransposon Replication Inside Cells

An arms race is occurring within human cells: Transposons, also known as jumping genes or mobile genetic elements, can replicate and reintegrate themselves into the genome, posing a threat to genomic integrity by inducing DNA rearrangements and mutations.

6 Mar 2025

Neural Mechanism Involved in Leptin Resistance Revealed

Worldwide obesity rates have more than doubled since 1990, with nearly a billion people now falling into the category.

5 Mar 2025

Colossal Creates the Colossal Woolly Mouse, Showcasing Breakthroughs in Multiplex Genome Editing and Trait Engineering on the Path to a Mammoth

In an extraordinary achievement of advanced multiplexed genome engineering, Colossal Biosciences announces the birth of the Colossal Woolly Mouse—mice engineered to express multiple key mammoth-like traits that provide adaptations to life in cold climates.

5 Mar 2025

New CRISPR Method Enhances Surveillance of Antibiotic Resistance in Wastewater

Antibiotic resistance is a global concern that threatens our ability to prevent and treat bacterial infections in humans and animals.

4 Mar 2025

Novel Python Pipeline Enables Genome-Scale Primer Design for Accurate Diagnostics

Zhang Liye Laboratory researchers have created a new tool that will change the way researchers design primers for pathogen detection.

4 Mar 2025

New Tool to Map the Origins and Journeys of Cells in Development and Disease

A new computational tool allows researchers to understand how the diverse cell types of the human body are made during development, and how diseases progress over time at the cellular level.

4 Mar 2025

Lactylation Levels Influence Cardiac Development and Regeneration in Mice

This study is led by Dr. Xiaodong Luan (Institute of Clinical Medicine, Peking Union Medical College Hospital), Dr. Shuyang Zhang (Department of Rare Diseases, Peking Union Medical College Hospital) and Dr. He Huang (Shanghai Institute of Materia Medica, Chinese Academy of Sciences).

3 Mar 2025