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Study Shows How Age-Related Metabolic Decline Impairs the Efficacy of CAR-T Cell Therapy

A Ludwig Cancer Research study has discovered that the metabolic decline that accompanies aging impairs the efficacy of CAR-T cell therapy, an immunotherapy in which T cells of the immune system are taken from patients, engineered to target cancer cells and reinfused into the same patients for treatment.

26 May 2025

Study Reveals How Genetic Differences in TRIO Affect Neurodevelopment

Researchers have identified how variations in a gene called TRIO can influence brain functions and result in distinct neurodevelopmental diseases.

24 May 2025

New LLNL Method Accelerates Protein Screening for Drug Discovery

Machine learning and supercomputing have brought about a revolution in computational drug discovery.

24 May 2025

Waters Acquires Halo Labs, Expanding Biological Analysis Portfolio

Waters Corporation today announced that it has acquired Halo Labs™, an innovator of specialized imaging technologies to detect, identify, and count interfering materials (particles) in therapeutic products, such as cell, protein, and gene therapies.

23 May 2025

Scientists Develop Method to Overcome Key Limitations of Cryo-EM

Sample loss has been a persistent problem in cryo-EM, a high-tech method for creating 3D models of molecules that reveals their inner structures.

22 May 2025

New CRISPR Technology for Precise RNA Delivery in Neurons

Proteins produced by RNA segments can aid in the repair of damaged neurons in human bodies.

22 May 2025

New Discovery Explains Increased Infection Risk in Patients with Mitochondrial Diseases

Patients with rare mitochondrial diseases already face a host of serious health issues, from muscle weakness to neurological problems and heart conditions.

21 May 2025

Autophagy: A Double-Edged Sword in Cancer and Protein Conformational Disorders

A new FEBS Letters review explores the dual role of autophagy in cancer and protein misfolding diseases—highlighting its potential as a therapeutic target and the challenges of tipping the balance between protection and harm.

20 May 2025

Novel Bacterial Immune Weapon that Starves Viral Invaders

The discovery of Cat1 reveals how CARF effectors use complex structures to inhibit viral replication, advancing our understanding of bacterial immune responses.

19 May 2025

New Mechanism for Selective Host-Microbe Communication in the Gut

The study reveals how APOL9 selectively binds to gut bacteria, enhancing immune responses and maintaining intestinal health through microbial communication.

15 May 2025

Skin Microbiome Found to Help Regulate Immune Response to UV Radiation

The skin microbiome plays an important role in health and disease. Researchers have now substantiated that certain skin bacteria can protect us from the sun's ultraviolet (UV) radiation specifically by metabolizing cis-urocanic acid using an enzyme called urocanase.

14 May 2025

Unraveling the Genetic Basis of Biosurfactant Production in an Oil-Degrading Bacterium

The marine bacterium Alcanivorax borkumensis consumes oil and proliferates rapidly following oil spills, thereby enhancing the removal of pollution in many instances.

12 May 2025

Novel Molecule Inducing Ferroptosis for Metastatic Cancer Therapy

Scientists from Institut Curie, the CNRS, and Inserm have just created a novel class of molecules capable of destroying cancer cells that are resistant to current treatments and cause recurrence.

8 May 2025

Carbon Insertion Technique Opens New Chemical Space for Medicines

A research team from the University of Oklahoma has developed an innovative method that has the potential to speed up drug discovery and lower pharmaceutical development expenses.

7 May 2025

New Drug Combo Shows Promise Against Aggressive Leukemia in Landmark Study

A novel drug combination targeting LSD1 and GSK3 shows promise in treating acute myeloid leukemia by promoting cell differentiation and reducing tumor growth.

28 Apr 2025

How Bacteria Outsmart Plant Immunity Using a Sugar-Coated Trick

In the intricate world of plant-microbe interactions, plants are continuously defending themselves against invading bacteria. New research highlights the sophisticated strategies these bacterial invaders employ.

23 Apr 2025

Guinea Pig Modeling To Study Human Preimplantation and Embryogenesis

Research on guinea pig embryos uncovers similarities to human embryogenesis, advancing understanding of preimplantation stages and reproductive techniques.

23 Apr 2025

Likarda Paper Highlights Hydrogel Encapsulation with CSS Can Overcome Major Obstacle of Liver Cell Therapies

Likarda, a leading biotech company specializing in the development of enabling technologies for the delivery of both cell therapies and large molecule biologics, announced a new peer-reviewed publication that demonstrates a promising improvement in the effort to develop liver cell-based therapies for patients with chronic liver disease.

23 Apr 2025

ORNL Scientists Develop Fluorescent Biosensor to Track RNA in Plants

Scientists at Oak Ridge National Laboratory have developed a first-ever method of detecting ribonucleic acid, or RNA, inside plant cells using a technique that results in a visible fluorescent signal.

16 Apr 2025

Peptide Imitation is the Sincerest Form of Plant Flattery

Industrial farming practices often deplete the soil of important nutrients and minerals, leaving farmers to rely on artificial fertilizers to support plant growth. In fact, fertilizer use has more than quadrupled since the 1960s, but this comes with serious consequences.

16 Apr 2025