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New Platform Enables Ultra-Detailed Imaging of Human Brain Tissue

Researchers reveal that a novel technology allows for the simultaneous capture at many scales of neuronal projection, synapse distribution, cellular architecture, and protein expression in large-scale human brain tissues.

14 Jun 2024

First Evidence of Oocyte Cohesion Rejuvenation Discovered in Fruit Flies

A Dartmouth study conducted on fruit flies reports the first evidence in any organism that oocytes-;the cells that become eggs-;regularly rejuvenate the critical protein linkages that bind chromosomes together.

13 Jun 2024

Human Antibodies Offer Hope for Improved Black Widow Antivenom

Sera produced from horses can be used to treat serious illnesses caused by black widow bites. But this approach is not totally secure. To address this, scientists have produced entirely human antibodies that are capable of neutralizing the European black widow's alpha-latrotoxin.

13 Jun 2024

Mitochondria Influence the Ability of Adult Cardiac Cells to Multiply

Whether forcing adult cardiomyocytes to reverse from the oxidative phosphorylation phenotype to the glycolysis phenotype would also restore their mitotic ability.

13 Jun 2024

New Study Reveals Microbial Role in Soil Carbon Emissions

When soil microbes eat plant matter, the digested food follows one of two pathways. Either the microbe uses the food to build its own body, or it respires its meal as carbon dioxide (CO2) into the atmosphere.

12 Jun 2024

Ancient Archaea Reveal Secrets of Hydrogen Utilization

An international scientific team has redefined our understanding of archaea, a microbial ancestor to humans from two billion years ago, by showing how they use hydrogen gas.

12 Jun 2024

Virus-Like Nanoparticles Facilitate DNA Release and Host Reproduction in Streptomyces

Viruses are ubiquitous in the environment, and organisms have developed various mechanisms to counter their threat.

12 Jun 2024

Simplified Proteomics Method Could Open the Door Toward Precision Medicine

Proteins are workhorses that carry out most of the biological functions in our cells.

12 Jun 2024

Innovative ssREAD Database Provides Rich Alzheimer's Disease RNA-Seq Resources for Researchers

The Single-cell and Spatial RNA-seq databasE for Alzheimer’s Disease, or ssREAD.

12 Jun 2024

Super-Cooled Brain Cell Molecules Shed Light on Epilepsy Drug Action

By super cooling a molecule on the surface of brain cells down to about minus 180 degrees Celsius -; nearly twice as cold as the coldest places in Antarctica -; scientists at Johns Hopkins Medicine say they have determined how a widely-used epilepsy drug works to dampen the excitability of brain cells and help to control, although not cure, seizures.

11 Jun 2024

Water-Soluble Bacterial Enzyme Could Enable Rapid Screening of Potential Antibiotics

A bacterial enzyme called histidine kinase is a promising target for new classes of antibiotics. However, it has been difficult to develop drugs that target this enzyme, because it is a "hydrophobic" protein that loses its structure once removed from its normal location in the cell membrane.

11 Jun 2024

Lung Organoids Shed Light on Pseudomonas aeruginosa's Invasive Tactics

How do pathogens invade the lungs? Using human lung microtissues, a team at the Biozentrum of the University of Basel has uncovered the strategy used by a dangerous pathogen.

11 Jun 2024

Engineered Enzyme Boosts Gene Editing Efficiency for Potential Cystic Fibrosis Treatment

Researchers at the Broad Institute of MIT and Harvard have enhanced a gene-editing technology, enabling it to efficiently insert or substitute entire genes in the genome of human cells.

11 Jun 2024

CARA Benchmark Set to Revolutionize Data-Driven Drug Discovery Methods

A compound activity prediction benchmark they curated for real-world, practical applications called Compound Activity benchmark for Real-world Applications (CARA).

11 Jun 2024

Study Highlights Key Protein-Lipid Interactions in Mitochondrial Energy Production

By studying mutations in yeast and human cells, Johns Hopkins Medicine scientists say they have found that biochemical bonds between fats and proteins in the mitochondrion, the cell's powerhouse, play a crucial role in how our cells produce energy.

10 Jun 2024

Study Finds Essential Role of Orco Protein in Ant Olfactory Neuron Survival and Social Interaction

While smell plays a considerable role in the social interactions of humans-;for instance, signaling fear or generating closeness-;for ants, it is vitally important.

10 Jun 2024

Peptidomimetics Unlock New Potential in Drug Discovery

Collaborating with the Universities of Bristol and Leeds, researchers at the University of Birmingham have effectively demonstrated a method for modifying peptides to transform them into potentially useful tools for drug discovery and disease diagnosis

10 Jun 2024

New research identifies and mitigates bias in CRISPR-Cas9 gene editing

A phenomics approach to study proximity bias and the unrelated chromosomal truncations.

10 Jun 2024

Multiciliated Cell Differentiation Regulated by an Alternative Cell Cycle

A fertilized egg can develop into a baby through the amazing process of cell division, while a malignant cell can become a malignant tumor. Since there is so much on the line, nature maintains strict control over it through a mechanism known as the cell cycle that scientists once believed they thoroughly understood.

7 Jun 2024

Study Reveals Diversity of DNA Transposons and Expands Genome Engineering Toolbox

In a study published in Cell, a research team led by Zhang Yong'e and WANG Haoyi from the Institute of Zoology of the Chinese Academy of Sciences has characterized the diversity of DNA transposons and expanded the genome engineering toolbox.

7 Jun 2024

Cell News and Research

New Platform Enables Ultra-Detailed Imaging of Human Brain Tissue

First Evidence of Oocyte Cohesion Rejuvenation Discovered in Fruit Flies

Human Antibodies Offer Hope for Improved Black Widow Antivenom

Mitochondria Influence the Ability of Adult Cardiac Cells to Multiply

New Study Reveals Microbial Role in Soil Carbon Emissions

Ancient Archaea Reveal Secrets of Hydrogen Utilization

Virus-Like Nanoparticles Facilitate DNA Release and Host Reproduction in Streptomyces

Simplified Proteomics Method Could Open the Door Toward Precision Medicine

Innovative ssREAD Database Provides Rich Alzheimer's Disease RNA-Seq Resources for Researchers

Super-Cooled Brain Cell Molecules Shed Light on Epilepsy Drug Action

Water-Soluble Bacterial Enzyme Could Enable Rapid Screening of Potential Antibiotics

Lung Organoids Shed Light on Pseudomonas aeruginosa's Invasive Tactics

Engineered Enzyme Boosts Gene Editing Efficiency for Potential Cystic Fibrosis Treatment

CARA Benchmark Set to Revolutionize Data-Driven Drug Discovery Methods

Study Highlights Key Protein-Lipid Interactions in Mitochondrial Energy Production

Study Finds Essential Role of Orco Protein in Ant Olfactory Neuron Survival and Social Interaction

Peptidomimetics Unlock New Potential in Drug Discovery

New research identifies and mitigates bias in CRISPR-Cas9 gene editing

Multiciliated Cell Differentiation Regulated by an Alternative Cell Cycle

Study Reveals Diversity of DNA Transposons and Expands Genome Engineering Toolbox

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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