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Ancient Interbreeding Provided Modern Humans with Useful Genetic Variation

A new study provides fresh evidence that ancient interbreeding with archaic human species may have provided modern humans with genetic variation that helped them adapt to new environments as they dispersed across the globe.

22 Aug 2025

Discovery of Lysosomal Vacuolation Mechanism Sheds Light on Aging and Disease

New research, published today in the journal Science, shows how lysosomes - organelles that act like cells' waste disposal system - respond to stress by becoming abnormally bloated, a process called lysosomal vacuolation that is associated with numerous diseases.

22 Aug 2025

Breakthrough Technique Enables Large-Scale Study of Polar and Ionic Metabolites

Researchers from the McCullagh Group in Oxford University's Department of Chemistry have published an innovative method in Nature Protocols today (22 August) that provides comprehensive analysis of metabolites found in cells, tissues and biofluids.

22 Aug 2025

Mapping Kidney Cells Opens Path to Precision Medicine

A research team led by Indiana University School of Medicine physician scientists has made significant progress in mapping kidney cells that may one day allow for more accurate disease diagnosis.

22 Aug 2025

Single-Cell Map Reveals Epigenomic Regulation of Human Fat Tissue

A new study has created the first single-cell map of how DNA is regulated and organized inside different cell-types of human fat tissue.

21 Aug 2025

Machine Learning Model Accounts for Biological Variability in Culture Media Design

Cell culture is a foundational technology widely used across fields such as pharmaceutical production, regenerative medicine, food science, and materials engineering. A critical component of successful cell culture is the culture medium-a solution containing essential nutrients that support cell growth.

21 Aug 2025

Cancer Cells Steal Energy from Fat to Fuel Growth

UCSF scientists caught cancer cells in the act of breaking into fat cells and releasing their fat. The energy heist seems to be critical for the growth of deadly breast cancer.

21 Aug 2025

ISS National Lab-Sponsored Experiment Tests 3D Bioprinted Tissue for Growing Artificial Livers

To explore how 3D bioprinted liver tissue constructs complete with vascular channels behave in microgravity, the Wake Forest Institute for Regenerative Medicine (WFIRM) is sending an investigation to the International Space Station (ISS).

21 Aug 2025

New Tool Offers Insight Into When Genes Turn On and Off in the Brain

A Yale research team has created a new computer tool that can pinpoint when exactly genes turn on and off over time during brain development - a finding that may one day help doctors identify the optimal window to deploy gene therapy treatments.

20 Aug 2025

New Technology Maps Over 140 Proteins Across Human Tissues

Each organ in the human body contains different types of cells arranged in specific ways.

20 Aug 2025

New Research on Amylin Could Pave the Way for Next-Generation Obesity Drugs

Amylin, a hormone that regulates both appetite and blood sugar by activating three distinct brain receptors, might serve as the foundation for the next generation of obesity drugs.

20 Aug 2025

New Insights Reveal Bacterial Roots of Key Plant Hormone Enzymes

Terpenoids play vital roles in plant ecology-from repelling pests to attracting pollinators-and are produced by terpene synthases (TPSs) enzymes.

19 Aug 2025

Missing Microexons Disrupt Synapse-Related Proteins in Pediatric Glioma

A new study, led by researchers at Children's Hospital of Philadelphia (CHOP), identified tiny pieces of messenger RNA that are missing in pediatric high-grade glioma tumors but not in normal brain tissues.

19 Aug 2025

Amino Acids as Key Mediators in the Tumor Immune Dialogue

The tumor microenvironment is not just a site of cancer growth—it is a high-stakes metabolic contest where tumor and immune cells vie for limited resources.

19 Aug 2025

New Enzyme Technology Illuminates Hidden Sugar Patterns on Cells

Sugars known as glycans form dense envelopes around cells. But they're often ignored in biological investigations because, unlike DNA, proteins and other cellular components, tools to study them are lacking.

18 Aug 2025

New Method Enables Human Cells to Initiate Meiosis Outside the Body

More than one-sixth of adults around the world experience infertility in their lifetime. There is a high unmet need not only for increased access to affordable, high-quality fertility care for those in need but, importantly, also for new biomedical solutions that can address the root causes of infertility.

18 Aug 2025