Cytokine News and Research

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Lymphocytes play crucial role in controlling virus shedding in asymptomatic COVID-19 patients

COVID-19 remains stubbornly inconsistent. More than a million people have died and 35 million have been diagnosed, but a large fraction of people infected with the coronavirus--about 45%, according to recent estimates--show no symptoms at all.

15 Oct 2020

CAR T cell therapy can predict treatment outcomes in patients with large B-cell lymphoma

Scientists have identified cellular and molecular features of anti-CD19 CAR T cell infusion products that are correlated with large B-cell lymphoma (LBCL).

6 Oct 2020

T cells play a vital role in controlling SARS-CoV-2 during acute phase of infection

Ever since SARS-CoV-2 first appeared, researchers have been trying to understand whether sometimes the immune system does more harm than good during the acute phase of COVID-19. The latest study by researchers at La Jolla Institute for Immunology clearly argues in favor of the immune system.

17 Sep 2020

Study shows how neural circuits are refined in response to sensory cues

According to a study published in the Neuron journal in September 2020, immune cells play a surprising role in fine-tuning the neural circuits of the brain.

16 Sep 2020

New research helps illuminate a surprising mind-body connection

New research at Washington University School of Medicine in St. Louis helps illuminate a surprising mind-body connection.

15 Sep 2020

Researchers review the role of macrophage activation syndrome in COVID-19

A major percentage of COVID-19 cases have become so severe that hospital admissions have become mandatory for both monitoring and treatment.

10 Sep 2020

Natural killer cells could be a powerful weapon for fighting lung cancer

Immune cells called 'natural killer' (NK) cells could be a powerful weapon for fighting lung cancer, according to Australian researchers.

2 Sep 2020

Researchers identify an effective treatment for severe cases of COVID-19 infection

Scientists are trying to figure out how SARS-CoV-2 leads to a range of symptoms that appear to persist long after the active viral infection.

From Osaka University 1 Sep 2020

New 3D hydrogels show promise in cancer immunotherapy

A group of researchers have developed new hydrogels that make it possible to culture T lymphocytes or T cells found in the immune system.

1 Sep 2020

Cytokine storms in COVID-19 patients may prevent the development of long-term immunity

Shiv Pillai, MD, Ph.D., investigator in the Ragon Institute of MGH, MIT and Harvard and professor at Harvard Medical School (HMS), recently published a paper in Cell showing that that high levels of some cytokines seen in COVID-19 patients, as part of a cytokine storm, may prevent the development of long-term immunity to SARS-CoV-2, the virus that causes COVID-19.

20 Aug 2020

Study reveals a mechanism for lower-quality immune response in patients with severe COVID-19

The release of massive amounts of proteins called cytokines can lead to some of the most severe symptoms of COVID-19.

From Harvard Medical School 20 Aug 2020

Researchers develop CAR-T cell therapy based on TCR signal transduction

The T cell receptor (TCR) is a key receptor that is responsible for detecting tumor antigens in T cells.

4 Aug 2020

Supercomputer analyses point to a new pathway for COVID-19 inflammatory response

Analyses of lung fluid cells from COVID-19 patients conducted on a supercomputer point to patterns that may explain the body's response to SARS-CoV-2.

29 Jul 2020

Higher levels of specific protein linked with severity of COVID-19 symptoms

A new study found raised levels of transforming growth factor beta-induced protein (TGFBIp) in blood sampled from roughly 100 people hospitalized for COVID-19, and further found that elevated levels of both the normal and acetylated forms of TGFBIp correlated with the severity of disease symptoms in these patients.

27 Jul 2020

Clinical trial shows CAR-T cell therapy can be used for treating Hodgkin lymphoma

CAR-T cell therapy, which attacks cancer cells using a person's reprogrammed immune cells, has been used to treat Hodgkin lymphoma with remarkable success for the first time, according to the results of an early phase clinical trial led by researchers at UNC Lineberger Comprehensive Cancer Center and Baylor College of Medicine in Houston.

24 Jul 2020

New approach is more effective in treating certain blood cancers

Some of the most promising advances in cancer treatment have centered on immunotherapies that rev up a patient's immune system to attack cancer.

24 Jul 2020

Type 1 interferon deficiency in the blood could be a hallmark of severe COVID-19

Approximately 5% of people with Covid-19 progress to a severe or critical form, including the development of severe pneumonia that progresses to acute respiratory distress syndrome.

20 Jul 2020

Targeted radionuclide therapy creates a favorable tumor microenvironment in prostate cancer

Targeted radionuclide therapy has been found to create a favorable tumor microenvironment in prostate cancer that improves the effectiveness of immunotherapies.

14 Jul 2020

Single dose of tocilizumab improves survival in critically ill COVID-19 patients

Critically ill COVID-19 patients who received a single dose of a drug that calms an overreacting immune system were 45% less likely to die overall, and more likely to be out of the hospital or off a ventilator one month after treatment, compared with those who didn't receive the drug, according to a new study by a team from the University of Michigan.