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Spatial Transcriptomics Reshapes Musculoskeletal Research and Therapy

Conventional transcriptomic techniques have revealed much about gene expression at the population and single-cell level—but they overlook one crucial factor: spatial context.

10 Jun 2025

Gene Editing Using CRISPR and AAV6 Impacts Long-Term Regeneration of Blood Stem Cells

Scientists at the San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), Milan, have found that gene editing using CRISPR-Cas9 in combination with AAV6 vectors can trigger inflammatory and senescence-like responses in blood stem cells, compromising their long-term ability to regenerate the blood system.

4 Jun 2025

Peptide Metabolites: A New Frontier in Antiviral Therapies

Interest in antiviral treatments has grown significantly since the COVID-19 pandemic. Effective peptide treatments made from natural substances are in high demand right now due to the increased attention being paid to peptide-based drugs like Wegovy.

27 May 2025

New Stem Cell Islet Model Mimics Pancreatic Function More Accurately

Researchers led by Maike Sander, Scientific Director of the Max Delbrück Center, have developed a vascularized organoid model of hormone secreting cells in the pancreas.

24 May 2025

New Genomic Score Predicts Risk of Progression in Multiple Myeloma

A new risk assessment score developed by researchers at Dana-Farber Cancer Institute and the Broad Institute of MIT and Harvard reveals how multiple myeloma, a form of blood cancer, begins and progresses from precancerous to malignant states by tracing DNA mutations.

24 May 2025

New Strategy Eliminates Biofilms and Prevents Regrowth

Most people have encountered the black, grey, or pink stains of bacterial biofilms built up on the bathroom tiles or kitchen sink.

24 May 2025

Unraveling the Co-Evolution of Human Height and Basal Metabolic Rate

Taller stature and a higher basal metabolic rate are two characteristics that distinguish modern humans from non-human primates. A genetic variant that helped these traits co-evolve was discovered by researchers and published in Cell Genomics.

22 May 2025

CAR-T Cell Therapy Causes “Brain Fog,” Independent of Other Cancer Treatments

After treatment with CAR-T cells - immune cells engineered to attack cancer - patients sometimes tell their doctors they feel like they have "brain fog," or forgetfulness and difficulty concentrating.

13 May 2025

Novel Therapeutic Strategy for Healthy Aging and Longevity

An international study led by the Institut de Neurociències at the UAB (INc-UAB) found that raising levels of the Klotho protein in mice extends lifespan and improves both physical and cognitive health as they age.

8 May 2025

‘Superbug’ Found to Digest Medical Plastic

Pathogen shown to break down plastic used in sutures, stents, wound dressings and implants – raising new questions over device safety and hospital infections.

7 May 2025

3D Printing Collagen Scaffolds with Perfusable Systems for Tissue Engineering

Scientists have developed high-resolution 3D-printed collagen scaffolds with internal perfusion systems, enabling complex, vascularized tissue models that support cell viability, growth, and insulin secretion

6 May 2025

New Drug Combo Shows Promise Against Aggressive Leukemia in Landmark Study

A novel drug combination targeting LSD1 and GSK3 shows promise in treating acute myeloid leukemia by promoting cell differentiation and reducing tumor growth.

28 Apr 2025

Super Stem Cells Offer New Hope for IVF and Regenerative Medicine

The ‘super stem cells’ perform better than regular stem cells, being able to develop into many different cell types, researchers from the University of Copenhagen find, with many potential applications, including improved IVF treatment.

25 Apr 2025

Can Cells Hear? Study Finds Sound Alters Gene Activity and Blocks Fat Cell Development

Acoustic stimulation affects cell development and gene activity, revealing potential applications in biotechnology and obesity control through sound waves.

24 Apr 2025

Rapid Growth of Blood Cancer Driven by a Single Genetic ‘HIT’

A new study has unveiled when chronic myeloid leukaemia, a type of cancer that affects the blood and bone marrow, arises in life and how fast it grows.

10 Apr 2025

Study Reveals How Stiffened Osteocytes Contribute to Bone Loss in Aging

It's no coincidence that our bodies feel a little creakier as we age. The trillions of cells that make up our skeleton age too, and some change in ways that weaken the very structure of our bones.

7 Apr 2025

DNA Aptamers Offer Precision Attack Against Leukemia Stem Cells

Drug-carrying DNA aptamers can deliver a one-two punch to leukemia by precisely targeting the elusive cancer stem cells that seed cancer relapses, researchers at the University of Illinois Urbana-Champaign report.

4 Apr 2025

Study Finds Key Mechanism Behind Plasma Cell Migration for Lasting Immunity

Vaccine effectiveness relies on creating a strong antibody response that can be reactivated to fight future infections.

13 Mar 2025

Macrophages Use Bacterial Debris To Fine-Tune Immune Responses

Findings reveal macrophages' role in immune modulation through bacterial metabolites, paving the way for improved therapies for infections and inflammation.

6 Mar 2025

New Approach Could Protect Insulin-Producing Beta Cells from Damage Related to Diabetes

Researchers from the Icahn School of Medicine at Mount Sinai in New York have discovered a novel approach to protecting insulin-producing beta cells from the damaging effects of glucolipotoxicity-a harmful condition linked to the progression of type 2 diabetes (T2D).

5 Mar 2025