CRISPR News and Research

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In the late 1980s and mid-1990s, genomes of diverse lineages of bacteria and archaea (the latter representing a domain of single-celled prokaryotic microorganisms) revealed clusters of regularly interspaced short palindromic repeats, known today under the abbreviation CRISPR. Later it was found that these repeat sequences (previously considered disparate) share a common set of features.

Research Maps Complex Molecular Rules Governing Specialized Tumor Immunity

For decades, natural killer (NK) cells have been classified into two main groups based on surface markers: one specialized for cytokine production and the other for direct killing.

7 Sep 2026

AI-Designed Protein Vehicle Enables Lower RNA Dosing While Maximizing Therapeutic Protein Expression

Researchers at Helmholtz Munich and TUM have developed Synthetic Transfer Vehicles (STVs), an entirely new class of RNA transporters. To do so, they combined naturally occurring protein building blocks with synthetic protein structures designed using generative AI.

3 Sep 2026

Bulky Molecular CRISPR Systems Barely Fit Inside Single Viral Vectors

The ability to precisely adjust the expression of genes inside the human body - ramping up protective ones and tamping down harmful ones - holds enormous potential for treating and preventing disease.

31 Aug 2026

Single-Gene Edits Fall Short of Stopping Immune Rejection in Beta Cell Grafts

In people with type 1 diabetes, the immune system mistakenly destroys the pancreatic beta cells responsible for producing insulin. Patients therefore require lifelong insulin therapy to regulate their blood glucose levels.

21 Aug 2026

Advanced AI Tools Sift Through Complex Data to Find Gene Mutations

One of the most important goals of studying genetics is to find genes that are involved with diseases. The problem is that most diseases aren't caused by a single gene or mutation.

19 Aug 2026

Method Reveals How Influenza A Takes Over Host Cell Machinery

A new study identifies influenza A virus interactions with human proteins, uncovering mechanisms of paraspeckle disruption and insights for antiviral development.

4 Aug 2026

New Base Editing Strategy Rewrites Genetic Code to Minimize Huntington's Symptoms

A gene editing tool designed to precisely rewrite the gene that causes Huntington's disease reduced toxic protein fragments and symptoms associated with the disease in mice, researchers at the University of Illinois Urbana-Champaign report.

30 Jul 2026

Type I CRISPR Systems Regulate Embedded Innate Immunity Genes in Neisseria

The main function of CRISPR-Cas systems, the revolutionary tool scientists now employ to edit genes, is to defend bacteria against threats such as viruses called bacteriophages. Researchers have continued to study all flavors of CRISPR-Cas systems (to date, 2 classes, 7 types and 46 subtypes have been identified) to understand all their capabilities.

27 Jul 2026

CRISPR Gene Editing Reveals How Enhancer Hierarchies Regulate Gene Expression

Enhancers are pieces of DNA that act like switches, regulating when genes are turned on and off and how strongly they are activated.

23 Jul 2026

Bacteria Use CRISPR-Cas to Control Diverse Innate Defense Systems

All cellular life-from humans to bacteria-possesses two layers of immunity: innate and adaptive. Scientists have long understood how these two types of immunity work together in higher organisms but not in the microbial world.

23 Jul 2026

UC San Diego and Innovative Genomics Institute Partner to Develop Cutting-Edge Genomic Tools

The University of California San Diego and the Innovative Genomics Institute (IGI), founded by Nobel laureate and CRISPR gene editing co-discoverer Jennifer Doudna, announced a new partnership today to jointly develop cutting-edge genomic tools for addressing large-scale challenges in health and the environment.

21 Jul 2026

CRISPR Technology Enables First Successful Gene Editing in Biting Midges

Scientists have successfully edited the genome of biting midges, opening the door to new research on how these insects transmit disease.

20 Jul 2026

New Method Derives Red Blood Cell-Like Cells From Canine iPSCs

Blood transfusions are crucial in human and veterinary medicine, yet human blood reserves are in constant need of donors while blood bank systems in veterinary care are nearly non-existent.

20 Jul 2026

AI Breakthrough Generates Novel Synthetic RNA-Guided Nucleases

Artificial intelligence (AI)-designed proteins can now expand the CRISPR toolbox beyond what evolution has produced.

17 Jul 2026

Novel T Cell Immune Path Targets Aggressive Acute Myeloid Leukemia

Researchers at The University of Texas MD Anderson Cancer Center have discovered a new way in which T cells attack acute myeloid leukemia (AML) cells, which may help explain why AML is particularly sensitive to immune-based treatments and could guide the development of future cancer immunotherapies.

16 Jul 2026