CRISPR News and Research

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In the late 1980s and mid-1990s, genomes of diverse lineages of bacteria and archaea (the latter representing a domain of single-celled prokaryotic microorganisms) revealed clusters of regularly interspaced short palindromic repeats, known today under the abbreviation CRISPR. Later it was found that these repeat sequences (previously considered disparate) share a common set of features.

Loss of Zfy Genes Explains Why Some Sperm Fail

A study at the University of Hawaiʻi at Mānoa by researchers from the John A. Burns School of Medicine (JABSOM) found that losing a crucial male fertility gene causes infertility and alters the expression of hundreds of other genes.

17 Sep 2025

CRISPR Breakthrough Makes Cacao Plants More Resistant To Deadly Disease

This study shows CRISPR-Cas9 modifications to the TcNPR3 gene in cacao reduce Phytophthora susceptibility, supporting eco-friendly agricultural practices.

17 Sep 2025

Engineered Base Editor Corrects ACTA2 Mutation in Rare Childhood Disease

Multisystemic smooth muscle dysfunction syndrome (MSMDS) is a rare condition associated with stroke, aortic dissection (tearing) and death in childhood.

13 Sep 2025

New Method Discovers Genetic Switches More Quickly

Researchers led by Dubravka Vučićević at the Max Delbrück Center have developed a new method for discovering how DNA controls genes. Published in “Cell Genomics,” their technique can reveal the genetic “switches” that regulate important genes more quickly than existing methods.

10 Sep 2025

CRISPRi Screening Reveals Genetic Insights into Cyanobacteria Acclimation

Cyanobacteria are the most abundant photosynthetic microorganisms on Earth. They live in nearly every habitat throughout the world, from permafrost to hot springs and from soils to oceans.

5 Sep 2025

Scientists Uncover Hidden Role of Cas9 in Building Bacterial Immune Memory

When scientists discovered how bacteria protect themselves against viral invaders, called phages, in the early 2000s, little did they know they'd stumbled upon a revolutionary tool researchers could use to edit the DNA of living cells.

4 Sep 2025

DNA-Wrapped Nanoparticles Enhance Efficiency of Gene Editing Tools

With the power to rewrite the genetic code underlying countless diseases, CRISPR holds immense promise to revolutionize medicine.

2 Sep 2025

Genome-Wide Screening Approach Uncovers Genetic Brakes on Blood Cancer Growth

Australian researchers have used an innovative genome-wide screening approach to identify genes, and their encoded proteins, that play critical roles in the prevention of lymphoma development, revealing new potential treatment targets for these blood cancers.

22 Aug 2025

New Gene Silencers Offer Hope for Hereditary Blood Disorders

According to a recent study, chemical tags that were previously thought of as genetic clutter are really potent gene silencers; eliminating them could lead to safer treatments for hereditary blood disorders.

18 Aug 2025

Minimal Plant Genomes Made Possible by New Genetic Strategy

Ancient events in plant evolution have left behind large, duplicated regions in their genomes.

14 Aug 2025

AI-Powered Gene Editing Method Enables Unprecedented Precision

A research team headed by the University of Zurich has developed a powerful new method to precisely edit DNA by combining cutting-edge genetic engineering with artificial intelligence.

13 Aug 2025

Researchers Uncover How Macrophages Respond to Infection Stress

Fighting infections requires speed and accuracy. A team of researchers from CeMM and MedUni Vienna, led by Christoph Bock and Matthias Farlik, explored how macrophages—the body’s initial responders—handle this stress.

11 Aug 2025

Salk Scientists Use CRISPR to Uncover Microproteins Linked to Obesity

The obesity rate has more than doubled in the last 30 years, affecting more than one billion people worldwide.

8 Aug 2025

Parkinson’s Gene Mutation Blocks Vital Neuroprotective Signals

GBA1 mutations impair ciliary Hedgehog signaling in Parkinson's disease, reducing neuroprotective factors and highlighting a shared pathogenic pathway.

7 Aug 2025

Bacterial Battle Strategies Involve Durable Amyloid Armor

Amyloids are perhaps best known as a key driver of Alzheimer's disease.

30 Jul 2025

Proteins as a Natural Weapon Against Predatory Bacteria

Amyloids are perhaps best recognized as a major cause of Alzheimer’s disease.

30 Jul 2025

Gene Editing Offers New Hope to Stop Malaria Transmission

Mosquitoes kill more people each year than any other animal. In 2023, the blood-sucking insects infected a reported 263 million people with malaria, leading to nearly 600,000 deaths, 80% of which were children.

24 Jul 2025

Gat3 Knockout Disrupts Visual Information Encoding in Mice

Cells called astrocytes are about as abundant in the brain as neurons, but scientists have spent much less time figuring out how they contribute to brain functions.

23 Jul 2025

Improved Agrobacterium Strains Enhance Plant Genetic Engineering Efficiency

These mutations improve biocontainment, transformation stability, and overall performance in genetic engineering of plants.

22 Jul 2025

Gene Editing Reverses Symptoms of Rare Brain Disorder in Mice

Scientists have corrected gene mutations in mice causing an ultra-rare disease by editing DNA directly in the brain with a single injection, a feat with profound implications for patients with neurological diseases.

22 Jul 2025