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In the late 1980s and mid-1990s, genomes of diverse lineages of bacteria and archaea (the latter representing a domain of single-celled prokaryotic microorganisms) revealed clusters of regularly interspaced short palindromic repeats, known today under the abbreviation CRISPR. Later it was found that these repeat sequences (previously considered disparate) share a common set of features.

Molecular Machinery Discovery Informs AR Targeting in Endocrine Resistant Breast Cancer

Adelaide University researchers have found a DNA 'switch' that helps the body stop the growth of the most common form of breast cancer, providing new insights that could help with future treatments.

6 Nov 2026

Systematic Genetic Mapping Opens New Doors for Tuberculosis Drug Discovery

Rockefeller scientists have created the most comprehensive map to date of how essential genes interact in Mycobacterium tuberculosis (Mtb), the bacterium responsible for tuberculosis (TB).

5 Nov 2026

CRISPR Screen Uncovers COMPASS Pathway Role in Suppressing Gut Autoimmunity

3 Nov 2026

St. Jude Scientists Discover Gene-Regulatory Pathway Protecting Gut Immune Balance

Trillions of bacteria live in the human gut without triggering an immune response. Scientists at St. Jude Children's Research Hospital have now discovered a gene-regulatory pathway that helps maintain this delicate balance. Published today in Science Advances, they showed that a type of immune cell, regulatory T cells, co-opt a well-known general gene expression pathway called COMPASS to suppress inappropriate immune responses and prevent lethal inflammation and autoimmunity.

30 Oct 2026

Staged CsREF1-2 Application Boosts Transgenic Shoot Recovery in Citrus Species

Traditional breeding in citrus faces steep obstacles: apomixis produces maternal clones, a juvenile phase lasting 5 to 10 years delays fruiting, and high heterozygosity complicates trait inheritance.

29 Oct 2026

Switching on Healthy Silent Genes Reveals New Way to Treat Rare Genetic Disorder

WEHI researchers have discovered a way to release a genetic 'brake' that silences healthy genes in Prader-Willi syndrome, opening a potential new path to treating the condition.

27 Oct 2026

Squeezing Cell Nuclei Loosens DNA to Boost CRISPR Reprogramming Efficiency

Our cells hold about two meters of DNA, folded and compacted to fit inside a nucleus far narrower than a strand of human hair.

24 Oct 2026

Metabolic Reprogramming Enhances Gamma Delta CAR T Solid Tumor Clearance

By turning a patient's own immune cells into stronger cancer-fighting cells, CAR T-cell therapy has transformed how some blood cancers are treated. But it's been harder to extend this approach to solid tumors, including cancer that has spread to the bone.

21 Oct 2026

Novel Molecular Pathway Identified to Combat T-Cell Exhaustion in Cancer

Researchers at the UCLA Health Jonsson Comprehensive Cancer Center used a CRISPR screen to identify a key molecular pathway that drives exhaustion in cancer-fighting immune cells, limiting their ability to keep tumors under control.

16 Oct 2026

Improving CRISPR-Based Diagnostics for Sensitive Detection of Infectious RNA Viruses

Scientists have long used a powerful gene-editing tool called CRISPR to make precise changes to DNA.

14 Oct 2026

Scientists Discover Why High Levels of the Amino Acid Cysteine Are Toxic to Cells

Cysteine is one of the main building blocks that cells use to make proteins. But this amino acid is a double-edged sword–too much cysteine is toxic to the cell.

24 Sep 2026

A Tiny Worm Helps Scientists Unravel a Genetic Clue to Kidney Disease

A microscopic worm that has no kidneys is helping Rutgers scientists understand a genetic change suspected of causing a serious inherited kidney disease.

24 Sep 2026

Blocking Mitochondrial Iron Transport Protects Cells Against Elevated Cysteine Toxicity

Cysteine is one of the main building blocks that cells use to make proteins.

22 Sep 2026

Integrated DNA Technologies and Aldevron Launch New Cas9 mRNA Solutions to Accelerate Path From Gene Editing Research to Development

Danaher companies Integrated DNA Technologies (IDT), a global leader in genomics, and Aldevron, a premier manufacturing partner for DNA, RNA, and protein, today announced the launch of research grade S.p. Cas9 mRNA in wild type and SpyFi™ high-fidelity formats.

From Integrated DNA Technologies 18 Sep 2026

Single-Cell Multiomics Model Decodes Enhancer Networks in Rare Cell Populations

Understanding gene regulation may be the key to interpreting human disease genetics. Genes are regulated in part by stretches of DNA called enhancers, which define when, where, and how strongly each gene is turned on.

17 Sep 2026

Research Reveals Molecular Link Between Matrix Protein Motifs and Ameloblast Organization

Tooth enamel looks simple from the outside and consists of a hard, smooth surface built to withstand years of wear.

12 Sep 2026

Advanced Gene Editing Provides Essential Tool for Studying Early Human Embryonic Development

A study by researchers at Columbia University Vagelos College of Physicians and Surgeons has found that new cutting-edge techniques can accurately edit genes in human embryos-giving scientists indispensable tools for understanding normal human development-but has also uncovered important risks that currently preclude the use of the techniques in the clinic.

10 Sep 2026

Human Embryos Repair Single-Strand DNA Damage Reliably but Fail at Double-Strand Breaks

Although DNA repair is one of the fundamental processes required for normal human embryonic development, little has been known about how it operates during the earliest stages of development.

10 Sep 2026

Research Maps Complex Molecular Rules Governing Specialized Tumor Immunity

For decades, natural killer (NK) cells have been classified into two main groups based on surface markers: one specialized for cytokine production and the other for direct killing.

7 Sep 2026

AI-Designed Protein Vehicle Enables Lower RNA Dosing While Maximizing Therapeutic Protein Expression

Researchers at Helmholtz Munich and TUM have developed Synthetic Transfer Vehicles (STVs), an entirely new class of RNA transporters. To do so, they combined naturally occurring protein building blocks with synthetic protein structures designed using generative AI.

3 Sep 2026