Cell Death News and Research

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Ovarian Cancer Fluid Helps Tumors Evade Cell Death

Ascites in ovarian cancer rewires tumor metabolism, protecting cells from ferroptosis and promoting metastasis, revealing potential therapeutic targets.

27 May 2026

Study Identifies Potential Metabolic Biomarkers for Metastatic Castration-Resistant Tumors

Ceramides-lipid molecules in cells that affect many physiological functions including cell differentiation, migration, and death-and their metabolites have been implicated in the development of cancer and other conditions.

26 May 2026

High Protein Levels Bypass Functional BRCA Defenses to Generate Toxic Double-Strand Genomic Breaks

When it comes to cancer, tumor suppressor genes are usually thought of as the "good guys." These genes make proteins that protect and repair DNA in cells.

22 May 2026

Polymer Platforms Help Focus Immune Attack on Cancerous Tumors

Conventional immune checkpoint inhibitors, such as anti-PD-1/PD-L1 and anti-CTLA-4 antibodies, can reinvigorate T cells but typically benefit less than 30% of patients.

21 May 2026

Disrupted Honeycomb Cellular Patterns in the Early Brain May Drive Cancer and Birth Defects

University of Virginia School of Medicine scientists have revealed how mistakes in the final step of cell division can have dire consequences for developing brain cells. The findings offer important new insights into cancer and developmental disorders, helping explain how the body tries to protect itself and what happens when it can't.

21 May 2026

New 3D Human Liver Model Mimics Chronic Disease For 30 Days

Researchers developed a 3D liver model that functions for a month, replicating inflammation and fibrosis, crucial for studying liver diseases and therapies.

19 May 2026

Animals Adapt Rapidly Through Protein Networks, Not Genes

UT Southwestern Medical Center researchers have discovered a key molecular mechanism that allows animals to adapt to changing environmental conditions without altering their genes – an ability known as phenotypic plasticity.

15 May 2026

Interactions Across the Genome Drive Neurodevelopmental Risks

People who have the same deletion of a section of chromosome 16 are susceptible to neurodevelopmental disorders; however, some may simply show moderate psychological symptoms like anxiety or depression, while others may have significant intellectual disability or developmental delay.

6 May 2026

Long Read Sequencing Uncovers Telomere Length Variation Across Chromosomes

In a new proof-of-concept study published in Nature Communications, researchers at the University of Chicago analyzed genomic data from more than 2,500 participants in the national All of Us research program to estimate chromosome-specific telomere length (csTL).

30 Apr 2026

How the Microbiome Shapes Cancer Immunity and Therapy Response

This review examines how the human microbiome regulates anti-tumor immunity through DNA damage, inflammation, immune-cell activity, microbial metabolites, and tumor microenvironment remodeling. It highlights emerging microbiome-based strategies, including FMT, probiotics, prebiotics, engineered bacteria, and live biotherapeutics, while stressing the need for rigorous validation and clinical trials.

29 Apr 2026

Study Reveals the "Black Box" of Protein Quality Control in the ER

Over the past few years, Kivanç Birsoy of Rockefeller University and his colleagues in the Laboratory of Metabolic Regulation and Genetics have uncovered amazing information about the antioxidant glutathione, which has numerous vital functions in the body, including eliminating free radicals and repairing cellular damage.

20 Apr 2026

How Mitochondrial Damage Accelerates Stem Cell Aging

Hematopoietic stem cells (HSCs), the cells that produce all blood cell types, start to lose their efficacy as one ages, which eventually reduces the ability to maintain healthy blood and a robust immune system.

17 Apr 2026

"Zombie" Macrophages Accumulate in Aging Tissues and Diseased Livers

UCLA researchers have identified a rogue population of immune cells that quietly accumulates in aging tissues and in the livers of people with fatty liver disease. Clearing these cells, they found, dramatically reduced inflammation and reversed liver damage in mice - even while the animals remained on an unhealthy diet.

16 Apr 2026